Utilizing Protein During Weight Loss to Impact Physical Function (UPLIFT)
Obesity, Weight Loss, Diet Modification
About this trial
This is an interventional treatment trial for Obesity
Eligibility Criteria
Inclusion Criteria:
- 65-85 years
- BMI: 27-45 kg/m2
- No regular resistance training and/or aerobic exercise (>20 mins/d) for past 6 months
- eSPPB <2.5
- No contraindications for safe and optimal participation in exercise training
- Approved for participation by Medical Director (Dr. Lyles)
- Willing to provide informed consent
- Agree to all study procedures and assessments
- Willing to consume protein/CHO supplements for up to 18 months
- Able to provide own transportation to study visits and intervention sessions
Exclusion Criteria:
- Weight loss (≥5%) in past 6 months
- Dependent on cane or walker
- Cognitive impairment (MoCA score <22)
- Severe arthritis, or other musculoskeletal disorder
- Joint replacement or other orthopedic surgery in past 6 months
- Uncontrolled resting hypertension (>160/90 mmHg);
- Insulin-dependent or uncontrolled diabetes (HbA1c ≥8%)
- Current or recent past (within 1 year) severe symptomatic heart disease, uncontrolled angina, stroke, chronic respiratory disease requiring oxygen; uncontrolled endocrine/metabolic disease; neurological or hematological disease; cancer requiring treatment in past year, except non-melanoma skin cancers; liver or renal disease; or clinically evident edema
- Unstable, severe depression
- Serious conduction disorder, uncontrolled arrhythmia, or new Q waves or ST-segment depressions (>3 mm at rest or ≥2 mm with exercise)
- Abnormal kidney function (eGFR <30 based on serum creatinine, age, gender, and race)
- Anemia (Hb<13 g/dL in men; <12 g/dL in women)
- Drug abuse or excessive alcohol use (>7 drinks/week women; >14 drinks/week men)
- Use of any tobacco or nicotine products in the past year
- Osteoporosis (T-score < -2.5 on hip or spine scan)
- Regular use of growth/steroid hormones, sex steroids or corticosteroids, osteoporosis medication, or protein supplements
- Weight loss medications or procedures
- Current participation in another intervention study
Sites / Locations
- Geriatric Research Center at Wake Forest Baptist Health
Arms of the Study
Arm 1
Arm 2
Arm 3
Placebo Comparator
Active Comparator
Active Comparator
RecProt
6-mon HiProt
18-mon HiProt
Lower protein / higher CHO diet for the 6-month weight loss phase. Exercise intervention months 0-6. Weight loss intervention months 0-6. Carbohydrate supplement for months 0-6 (blinded). Follow-up months 7-18.
Higher protein / lower CHO diet for the 6-month weight loss phase. Exercise intervention months 0-6. Weight loss intervention months 0-6. Protein supplement for months 0-6 (blinded). Follow-up months 7-18.
Higher protein / lower CHO diet for the 6-month weight loss and 12-month follow-up phases. Exercise intervention months 0-6. Weight loss intervention months 0-6. Protein supplement for months 0-6 (blinded). Protein supplement for follow-up months 7-18.