Ureteric Visualization: Vitamin B Vs 5% Dextrose in Water
Pelvic Floor Disorders, Ureter; Kink
About this trial
This is an interventional diagnostic trial for Pelvic Floor Disorders focused on measuring Vitamin B, 5% Dextrose in Water, Cystoscopy, Ureter
Eligibility Criteria
Inclusion Criteria:
- Females undergoing pelvic reconstructive surgery for pelvic organ prolapse where cystoscopy is necessary to assess ureteric integrity
Exclusion Criteria:
- Known kidney disease
- Known ureteral disease or previous ureteric compromise
- Patients with known hypersensitivity to cyanocobalamin or cobalt
- Known malabsorption disorder
- Known allergy to fluorescein dye
- Unable to present for one week post-operative assessment due to geographic or transportation issues
- Unable to provide written consent to the study as a result of language barriers or cognitive disabilities
Sites / Locations
- Sunnybrook Health Sciences Centre
- Mount Sinai Hospital
Arms of the Study
Arm 1
Arm 2
Experimental
Active Comparator
Vitamin B
D5W (5% dextrose in water)
Vitamin B: Patients in this arm will receive 100mg of riboflavin (vitamin B2) 60 to 120 minutes prior to surgery for the purpose of turning the urine bright yellow to see if this helps with detection of ureteric jets during cystoscopy which will be done using normal saline.
5% Dextrose in Water: Patients in this arm will receive a placebo in the pre-operative area (for the purpose of blinding the surgical team) 60 to 120 minutes prior to surgery. Intraoperative cystoscopy will then be performed using D5W to see if this helps with detection of ureteric jets.