Assessment of Apathy in a Real-life Situation, With a Video and Sensors-based System (ECOCAPTURE)
Apathy, Frontotemporal Dementia, Parkinson Disease
About this trial
This is an interventional diagnostic trial for Apathy focused on measuring Apathy, Goal-directed behavior, Assessment, Diagnosis, Sensor, Ecological condition, Neurological disease
Eligibility Criteria
Inclusion Criteria:
All groups:
- Ability to give informed consent for study procedures
- Ability to understand study instructions and to realize the cognitive tasks
- Person with health insurance
Patients:
- MMS>20
- Absence of another neurological or psychiatric disease
- Presence of a caregiver
We will recruit three groups of patients:
- diagnosed with behavioral variant frontotemporal dementia (bvFTD) according to the Rascovsky criteria (Rascovsky et al. 2011)
diagnosed with idiopathic Parkinson's disease (Hughes et al. 1992)
- Sub-group 1: Parkinson's disease with Impulse Control Disorders (ICDs)
- Sub-group 2: Parkinson's disease without Impulse Control Disorders (ICDs)
- diagnosed with depression (Major Depressive Disorder, DSM-IV)
Healthy age,sex, education-matched controls:
- MMS>27
- Absence of neurological or psychiatric disease
Exclusion Criteria:
- Standard contraindications to MRI
- Inability to understand study instructions
- Person mentioned in the article L.1121-5 to L. 1121-8 and L. 1122-12 of the French Public Health Code
Sites / Locations
- ICM / Pitié-Salpêtrière Hospital AP-HP / CICRecruiting
Arms of the Study
Arm 1
Arm 2
Arm 3
Arm 4
Arm 5
Experimental
Experimental
Experimental
Experimental
Experimental
bvFTD
Healthy control
Parkinson's disease without Impulse Control Disorders (ICDs)
Depression
Parkinson's disease with Impulse Control Disorders (ICDs)
Initially especially patients diagnosed with behavioral variant frontotemporal dementia (bvFTD) according to the Rascovsky criteria (Rascovsky et al. 2011). ECOCAPTURE / ICM_APATHY_TASKS / Cognitive and Behavioral experimental tasks / Neuropsychological assessment / MRI / Neurohormonal mechanisms
Healthy age, sex and education matched controls ECOCAPTURE / ICM_APATHY_TASKS / Cognitive and Behavioral experimental tasks / Neuropsychological assessment / MRI / Neurohormonal mechanisms
Initially especially patients diagnosed with idiopathic Parkinson's disease (Hughes et al. 1992). ECOCAPTURE / ICM_APATHY_TASKS / Cognitive and Behavioral experimental tasks / Neuropsychological assessment / Supplementary Neuropsychological assessment - Parkinson's disease / MRI / Neurohormonal mechanisms
Initially especially patients diagnosed with depression (Major Depressive Disorder, DSM-IV). ECOCAPTURE / ICM_APATHY_TASKS / Cognitive and Behavioral experimental tasks / Neuropsychological assessment / MRI / Neurohormonal mechanisms
Initially especially patients diagnosed with idiopathic Parkinson's disease (Hughes et al. 1992). ICDs are closely related to use of dopaminergic medications. ECOCAPTURE / ICM_APATHY_TASKS / Cognitive and Behavioral experimental tasks / Neuropsychological assessment / Supplementary Neuropsychological assessment - Parkinson's disease / MRI / Neurohormonal mechanisms