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Assessment of Apathy in a Real-life Situation, With a Video and Sensors-based System (ECOCAPTURE)

Primary Purpose

Apathy, Frontotemporal Dementia, Parkinson Disease

Status
Unknown status
Phase
Not Applicable
Locations
France
Study Type
Interventional
Intervention
ECOCAPTURE
Cognitive and Behavioral experimental tasks
Neuropsychological assessment
ICM_APATHY_TASKS
MRI
Neurohormonal mechanisms
Supplementary Neuropsychological Assessment - Parkinson's Disease
Sponsored by
Institut National de la Santé Et de la Recherche Médicale, France
About
Eligibility
Locations
Arms
Outcomes
Full info

About this trial

This is an interventional diagnostic trial for Apathy focused on measuring Apathy, Goal-directed behavior, Assessment, Diagnosis, Sensor, Ecological condition, Neurological disease

Eligibility Criteria

40 Years - 85 Years (Adult, Older Adult)All SexesAccepts Healthy Volunteers

Inclusion Criteria:

All groups:

  • Ability to give informed consent for study procedures
  • Ability to understand study instructions and to realize the cognitive tasks
  • Person with health insurance

Patients:

  • MMS>20
  • Absence of another neurological or psychiatric disease
  • Presence of a caregiver
  • We will recruit three groups of patients:

    • diagnosed with behavioral variant frontotemporal dementia (bvFTD) according to the Rascovsky criteria (Rascovsky et al. 2011)
    • diagnosed with idiopathic Parkinson's disease (Hughes et al. 1992)

      • Sub-group 1: Parkinson's disease with Impulse Control Disorders (ICDs)
      • Sub-group 2: Parkinson's disease without Impulse Control Disorders (ICDs)
    • diagnosed with depression (Major Depressive Disorder, DSM-IV)

Healthy age,sex, education-matched controls:

  • MMS>27
  • Absence of neurological or psychiatric disease

Exclusion Criteria:

  • Standard contraindications to MRI
  • Inability to understand study instructions
  • Person mentioned in the article L.1121-5 to L. 1121-8 and L. 1122-12 of the French Public Health Code

Sites / Locations

  • ICM / Pitié-Salpêtrière Hospital AP-HP / CICRecruiting

Arms of the Study

Arm 1

Arm 2

Arm 3

Arm 4

Arm 5

Arm Type

Experimental

Experimental

Experimental

Experimental

Experimental

Arm Label

bvFTD

Healthy control

Parkinson's disease without Impulse Control Disorders (ICDs)

Depression

Parkinson's disease with Impulse Control Disorders (ICDs)

Arm Description

Initially especially patients diagnosed with behavioral variant frontotemporal dementia (bvFTD) according to the Rascovsky criteria (Rascovsky et al. 2011). ECOCAPTURE / ICM_APATHY_TASKS / Cognitive and Behavioral experimental tasks / Neuropsychological assessment / MRI / Neurohormonal mechanisms

Healthy age, sex and education matched controls ECOCAPTURE / ICM_APATHY_TASKS / Cognitive and Behavioral experimental tasks / Neuropsychological assessment / MRI / Neurohormonal mechanisms

Initially especially patients diagnosed with idiopathic Parkinson's disease (Hughes et al. 1992). ECOCAPTURE / ICM_APATHY_TASKS / Cognitive and Behavioral experimental tasks / Neuropsychological assessment / Supplementary Neuropsychological assessment - Parkinson's disease / MRI / Neurohormonal mechanisms

Initially especially patients diagnosed with depression (Major Depressive Disorder, DSM-IV). ECOCAPTURE / ICM_APATHY_TASKS / Cognitive and Behavioral experimental tasks / Neuropsychological assessment / MRI / Neurohormonal mechanisms

Initially especially patients diagnosed with idiopathic Parkinson's disease (Hughes et al. 1992). ICDs are closely related to use of dopaminergic medications. ECOCAPTURE / ICM_APATHY_TASKS / Cognitive and Behavioral experimental tasks / Neuropsychological assessment / Supplementary Neuropsychological assessment - Parkinson's disease / MRI / Neurohormonal mechanisms

Outcomes

Primary Outcome Measures

Occurrence of each behavior from the ethogram
[Provided by the video recording and The Observer NOLDUS software] integer.
Frequency of each behavior from the ethogram
[Provided by the video recording and The Observer NOLDUS software] integer.
Duration of each behavior from the ethogram
[Provided by the video recording and The Observer NOLDUS software] integer.
Number of different behaviors
[Provided by the video recording and The Observer NOLDUS software] integer.
Activity classes
[Provided by the MOVE MOVISENS sensor] lying, sitting, ...
Body positions
[Provided by the MOVE MOVISENS sensor] lying left, ...
Energy expenditure
[Provided by the MOVE MOVISENS sensor] kcal.
MET
[Provided by the MOVE MOVISENS sensor] The Metabolic Equivalent of Task: MET level.
Steps
[Provided by the MOVE MOVISENS sensor] Counting steps.
Acceleration intensity
[Provided by the MOVE MOVISENS sensor] g.
Pupil Diameter x
[Provided by the eye-tracking glasses SMI ETG 2w] mm.
Pupil Diameter y
[Provided by the eye-tracking glasses SMI ETG 2w] mm.

Secondary Outcome Measures

ICM_APATHY_TASKS
ICM_APATHY_TASKS global score
MMSE
[Mini Mental State Exam] MMSE global score
MATTIS
[Mattis Dementia Rating Scale ] MATTIS global score
NART
[National Adult Reading Test] NART IQ (global score)
BREF (FAB english)
[Frontal Assessment Battery] BREF global score
HAYLING
[Hayling Sentence Completion test] ] HAYLING global score
HAD
[Hospital Anxiety and Depression Scale] ]HAD global score
Gray matter volume
[MRI analysis- Brain segmentation] mm3
White matter volume
[MRI analysis- Brain segmentation] mm3
Cerebral Spinal Fluid volume
[MRI analysis- Brain segmentation] mm3
Brain lesion localization
[MRI analysis- Brain segmentation] Talairach x,y,z coordinates
IL-6
Hormonal result [Interleukin-6] pg/mL
Leptin
Hormonal result [Leptin] ng/mL
Adiponectin
Hormonal result [Blood adiponectin level)] mg/L
Insulin
Hormonal result [Fasting Insulin] mUI/L
C-Peptide
Diabetic result [Fasting C-Peptide level] µg/L
FPG
Diabetic result [Fasting Plasma Glucose] mmol/L
HbA1C
Diabetic result [Glycated Hemoglobin] %
K+
Ionogram result [Potassium] mmol/L
Uric acid
Ionogram result [Uric acid] µmol/L
Creatinine
Ionogram result [Creatinine] µmol/L
Total Protein
Ionogram result [Total protein] g/L
CRP
Inflammatory result [C-reactive protein] mG/L
AST
Hepatic result [Aspartate aminotransferase] U/L
ALT
Hepatic result [Alanine aminotransferase] U/L
GGT
Hepatic result [Gamma-glutamyltransferase] U/L
Cholesterol
Lipidic result [Total cholesterol] mmol/L
Triglycerides
Lipidic result [Triglycerides] mmol/L
HDL cholesterol
Lipidic result [High-density lipoprotein cholesterol] mmol/L
LDL cholesterol
Lipidic result [Low-density lipoprotein cholesterol] mmol/L
Glycerol
Lipidic result [Plasma glycerol concentration] mmol/L
FFAs
Lipidic result [Plasma free fatty acids] mmol/L
TSH
Thyroid result [Thyroid-stimulating hormone blood test] mmol/L
DAS
[Dimensional Apathy Scale] DAS global score
STARKSTEIN (SAS)
[Starkstein Apathy Scale (SAS)] SAS global score
MADRS
[Montgomery-Åsberg Depression Rating Scale] MADRS global score
EBI
[Eating Behavior Inventory] EBI global score
ACDD
[Autoévaluation des Comportements Dopamine Dépendants] ACDD answers
QUIP
[Questionnaire for Impulsive-Compulsive Disorders in Parkinson's Disease] QUIP answers
BIS-11
[Barratt Impulsiveness Scale] BIS-11 global score
Mini-SEA
[Mini Social cognition and Emotional Assesment] Mini-SEA global score
STROOP
[STROOP Test] STROOP global score
ECMP
[Evaluation Comportementale dans la Maladie de Parkinson] ECMP answers
QUIP-RS
[Questionnaire for Impulsive-Compulsive Disorders in Parkinson's Disease-Rating Scale] QUIP-RS global score

Full Information

First Posted
August 3, 2017
Last Updated
March 21, 2019
Sponsor
Institut National de la Santé Et de la Recherche Médicale, France
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1. Study Identification

Unique Protocol Identification Number
NCT03272230
Brief Title
Assessment of Apathy in a Real-life Situation, With a Video and Sensors-based System
Acronym
ECOCAPTURE
Official Title
Assessment of Apathy in a Real-life Situation, With a Video and Sensors-based System in Healthy Subject and Patient With Cerebral Disease
Study Type
Interventional

2. Study Status

Record Verification Date
March 2019
Overall Recruitment Status
Unknown status
Study Start Date
September 6, 2017 (Actual)
Primary Completion Date
July 31, 2019 (Anticipated)
Study Completion Date
February 28, 2022 (Anticipated)

3. Sponsor/Collaborators

Responsible Party, by Official Title
Sponsor
Name of the Sponsor
Institut National de la Santé Et de la Recherche Médicale, France

4. Oversight

Studies a U.S. FDA-regulated Drug Product
No
Studies a U.S. FDA-regulated Device Product
No
Data Monitoring Committee
No

5. Study Description

Brief Summary
Apathy can be defined as a quantitative reduction of voluntary or goal-directed behavior. So, the investigators propose a behavioral approach for assessing apathy, to obtain a quantifiable and objective signature of reduced goal-directed behavior by directly observing a patient in a real-life situation. ECOCAPTURE consists of a multi-step scenario in a functional exploration platform equipped with data acquisition system based on video and sensors that track a participant's behavior. The primary objective of this trial is to create a diagnostic tool for apathy, based on the video and sensors metrics. A secondary objective of this trial is to validate a new experimental task (ICM_APATHY_TASKS) to test independently three main presumed mechanisms of apathy (motivation, cognitive inertia and coupling between motivation and action). Another secondary objective aims to specify the pathophysiological mechanisms of apathy, corresponding to cognitive and behavioral processes, neural bases and neurohormonal mechanisms. The definition of pathophysiological mechanisms will allow the classification of apathetic patients (or several forms of apathy) and indicate which mechanism (s) best explains the apathy in a given patient.
Detailed Description
A pilot study ECOCAPTURE (ClinicalTrials.gov/NCT02496312, 2015) applied to a group of participants with the behavioural variant of frontotemporal lobar degeneration (bvFTLD) matched for age, gender and level of education to healthy participants (n=7 per group). This pilot validated the concept of ECOCAPTURE. The purpose of this trial is to continue the implementation of the ECOCAPTURE tool, extending it to three pathological models: bvFTLD, Parkinson's disease and depression. The objectives aim to assess behavior directed towards a goal and identify apathy, analyze data to obtain a behavioral signature of apathy and to produce more finely differentiated apathetic patients profiles by specifying the pathophysiological mechanisms (cognitive mechanisms, as well as the neural bases and the neuro-hormonal mechanisms) underlying apathy. The investigators use multimodal recording tools to track behavior. A multiple-camera system is set up with video coverage of the whole room. A sensor (Move II, Movisens, Karlsruhe, Germany) fixed to the subject's hip, records data such as 3D acceleration, barometric pressure and temperature. From these data, secondary parameters like activity class, body position, steps, energy expenditure and metabolic equivalents are calculated. Video data analysis is performed with The Observer XT software (Noldus, Wageningen, The Netherlands) using an ethogram to identify the frequency and duration of behaviors. For 10 min, during the experimental session, participants ware eye-tracking glasses (ETG 2w, SMI, Teltow, Germany) that record natural gaze behavior. Metrics built from raw data (video, sensors) are analyzed to reveal a behavioral signature of apathy, highlighting a quantitative reduction in goal-directed behavior. The study takes place on two visits (one per day). It consists of the observation phase, a neuropsychological assessment, experimental tasks, some of which are computerized, an MRI examination and finally a blood test.

6. Conditions and Keywords

Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
Apathy, Frontotemporal Dementia, Parkinson Disease, Depressive Symptoms
Keywords
Apathy, Goal-directed behavior, Assessment, Diagnosis, Sensor, Ecological condition, Neurological disease

7. Study Design

Primary Purpose
Diagnostic
Study Phase
Not Applicable
Interventional Study Model
Parallel Assignment
Masking
None (Open Label)
Allocation
Non-Randomized
Enrollment
135 (Anticipated)

8. Arms, Groups, and Interventions

Arm Title
bvFTD
Arm Type
Experimental
Arm Description
Initially especially patients diagnosed with behavioral variant frontotemporal dementia (bvFTD) according to the Rascovsky criteria (Rascovsky et al. 2011). ECOCAPTURE / ICM_APATHY_TASKS / Cognitive and Behavioral experimental tasks / Neuropsychological assessment / MRI / Neurohormonal mechanisms
Arm Title
Healthy control
Arm Type
Experimental
Arm Description
Healthy age, sex and education matched controls ECOCAPTURE / ICM_APATHY_TASKS / Cognitive and Behavioral experimental tasks / Neuropsychological assessment / MRI / Neurohormonal mechanisms
Arm Title
Parkinson's disease without Impulse Control Disorders (ICDs)
Arm Type
Experimental
Arm Description
Initially especially patients diagnosed with idiopathic Parkinson's disease (Hughes et al. 1992). ECOCAPTURE / ICM_APATHY_TASKS / Cognitive and Behavioral experimental tasks / Neuropsychological assessment / Supplementary Neuropsychological assessment - Parkinson's disease / MRI / Neurohormonal mechanisms
Arm Title
Depression
Arm Type
Experimental
Arm Description
Initially especially patients diagnosed with depression (Major Depressive Disorder, DSM-IV). ECOCAPTURE / ICM_APATHY_TASKS / Cognitive and Behavioral experimental tasks / Neuropsychological assessment / MRI / Neurohormonal mechanisms
Arm Title
Parkinson's disease with Impulse Control Disorders (ICDs)
Arm Type
Experimental
Arm Description
Initially especially patients diagnosed with idiopathic Parkinson's disease (Hughes et al. 1992). ICDs are closely related to use of dopaminergic medications. ECOCAPTURE / ICM_APATHY_TASKS / Cognitive and Behavioral experimental tasks / Neuropsychological assessment / Supplementary Neuropsychological assessment - Parkinson's disease / MRI / Neurohormonal mechanisms
Intervention Type
Behavioral
Intervention Name(s)
ECOCAPTURE
Intervention Description
45 minutes observational session for tracking goal directed behavior into a waiting room equipped with video and sensor-based data acquisition system
Intervention Type
Behavioral
Intervention Name(s)
Cognitive and Behavioral experimental tasks
Intervention Description
Cognitive and Behavioral experimental tasks to explore additional frontal cognitive and behavioral dimensions and functions
Intervention Type
Diagnostic Test
Intervention Name(s)
Neuropsychological assessment
Intervention Description
MMS / MADRS / EBI / NART / Mini-SEA / BREF / HAD / MATTIS / HAYLING / STROOP / STARKSTEIN / DAS
Intervention Type
Behavioral
Intervention Name(s)
ICM_APATHY_TASKS
Intervention Description
Apathy experimental task
Intervention Type
Other
Intervention Name(s)
MRI
Intervention Description
T1 MRI / T2 MRI / Resting state fMRI / Multi-shell diffusion-weighted MRI
Intervention Type
Biological
Intervention Name(s)
Neurohormonal mechanisms
Intervention Description
Hormonal dosage / Diabetic dosage / Ionogramme dosage / Inflammatory dosage / Hepatic dosage / Lipidic dosage / Thyroid dosage
Intervention Type
Diagnostic Test
Intervention Name(s)
Supplementary Neuropsychological Assessment - Parkinson's Disease
Intervention Description
ACDD / QUIP / BIS-11 / ECMP / QUIP-RS
Primary Outcome Measure Information:
Title
Occurrence of each behavior from the ethogram
Description
[Provided by the video recording and The Observer NOLDUS software] integer.
Time Frame
45 min
Title
Frequency of each behavior from the ethogram
Description
[Provided by the video recording and The Observer NOLDUS software] integer.
Time Frame
45 min
Title
Duration of each behavior from the ethogram
Description
[Provided by the video recording and The Observer NOLDUS software] integer.
Time Frame
45 min
Title
Number of different behaviors
Description
[Provided by the video recording and The Observer NOLDUS software] integer.
Time Frame
45 min
Title
Activity classes
Description
[Provided by the MOVE MOVISENS sensor] lying, sitting, ...
Time Frame
45 min
Title
Body positions
Description
[Provided by the MOVE MOVISENS sensor] lying left, ...
Time Frame
45 min
Title
Energy expenditure
Description
[Provided by the MOVE MOVISENS sensor] kcal.
Time Frame
45 min
Title
MET
Description
[Provided by the MOVE MOVISENS sensor] The Metabolic Equivalent of Task: MET level.
Time Frame
45 min
Title
Steps
Description
[Provided by the MOVE MOVISENS sensor] Counting steps.
Time Frame
45 min
Title
Acceleration intensity
Description
[Provided by the MOVE MOVISENS sensor] g.
Time Frame
45 min
Title
Pupil Diameter x
Description
[Provided by the eye-tracking glasses SMI ETG 2w] mm.
Time Frame
10 min
Title
Pupil Diameter y
Description
[Provided by the eye-tracking glasses SMI ETG 2w] mm.
Time Frame
10 min
Secondary Outcome Measure Information:
Title
ICM_APATHY_TASKS
Description
ICM_APATHY_TASKS global score
Time Frame
At day 1
Title
MMSE
Description
[Mini Mental State Exam] MMSE global score
Time Frame
At day 1
Title
MATTIS
Description
[Mattis Dementia Rating Scale ] MATTIS global score
Time Frame
At day 1
Title
NART
Description
[National Adult Reading Test] NART IQ (global score)
Time Frame
At day 1
Title
BREF (FAB english)
Description
[Frontal Assessment Battery] BREF global score
Time Frame
At day 1
Title
HAYLING
Description
[Hayling Sentence Completion test] ] HAYLING global score
Time Frame
At day 1
Title
HAD
Description
[Hospital Anxiety and Depression Scale] ]HAD global score
Time Frame
At day 1
Title
Gray matter volume
Description
[MRI analysis- Brain segmentation] mm3
Time Frame
At day 2
Title
White matter volume
Description
[MRI analysis- Brain segmentation] mm3
Time Frame
At day 2
Title
Cerebral Spinal Fluid volume
Description
[MRI analysis- Brain segmentation] mm3
Time Frame
At day 2
Title
Brain lesion localization
Description
[MRI analysis- Brain segmentation] Talairach x,y,z coordinates
Time Frame
At day 2
Title
IL-6
Description
Hormonal result [Interleukin-6] pg/mL
Time Frame
At day 1
Title
Leptin
Description
Hormonal result [Leptin] ng/mL
Time Frame
At day 1
Title
Adiponectin
Description
Hormonal result [Blood adiponectin level)] mg/L
Time Frame
At day 1
Title
Insulin
Description
Hormonal result [Fasting Insulin] mUI/L
Time Frame
At day 1
Title
C-Peptide
Description
Diabetic result [Fasting C-Peptide level] µg/L
Time Frame
At day 1
Title
FPG
Description
Diabetic result [Fasting Plasma Glucose] mmol/L
Time Frame
At day 1
Title
HbA1C
Description
Diabetic result [Glycated Hemoglobin] %
Time Frame
At day 1
Title
K+
Description
Ionogram result [Potassium] mmol/L
Time Frame
At day 1
Title
Uric acid
Description
Ionogram result [Uric acid] µmol/L
Time Frame
At day 1
Title
Creatinine
Description
Ionogram result [Creatinine] µmol/L
Time Frame
At day 1
Title
Total Protein
Description
Ionogram result [Total protein] g/L
Time Frame
At day 1
Title
CRP
Description
Inflammatory result [C-reactive protein] mG/L
Time Frame
At day 1
Title
AST
Description
Hepatic result [Aspartate aminotransferase] U/L
Time Frame
At day 1
Title
ALT
Description
Hepatic result [Alanine aminotransferase] U/L
Time Frame
At day 1
Title
GGT
Description
Hepatic result [Gamma-glutamyltransferase] U/L
Time Frame
At day 1
Title
Cholesterol
Description
Lipidic result [Total cholesterol] mmol/L
Time Frame
At day 1
Title
Triglycerides
Description
Lipidic result [Triglycerides] mmol/L
Time Frame
At day 1
Title
HDL cholesterol
Description
Lipidic result [High-density lipoprotein cholesterol] mmol/L
Time Frame
At day 1
Title
LDL cholesterol
Description
Lipidic result [Low-density lipoprotein cholesterol] mmol/L
Time Frame
At day 1
Title
Glycerol
Description
Lipidic result [Plasma glycerol concentration] mmol/L
Time Frame
At day 1
Title
FFAs
Description
Lipidic result [Plasma free fatty acids] mmol/L
Time Frame
At day 1
Title
TSH
Description
Thyroid result [Thyroid-stimulating hormone blood test] mmol/L
Time Frame
At day 1
Title
DAS
Description
[Dimensional Apathy Scale] DAS global score
Time Frame
At day 1
Title
STARKSTEIN (SAS)
Description
[Starkstein Apathy Scale (SAS)] SAS global score
Time Frame
At day 1
Title
MADRS
Description
[Montgomery-Åsberg Depression Rating Scale] MADRS global score
Time Frame
At day 1
Title
EBI
Description
[Eating Behavior Inventory] EBI global score
Time Frame
At day 1
Title
ACDD
Description
[Autoévaluation des Comportements Dopamine Dépendants] ACDD answers
Time Frame
At day 1
Title
QUIP
Description
[Questionnaire for Impulsive-Compulsive Disorders in Parkinson's Disease] QUIP answers
Time Frame
At day 1
Title
BIS-11
Description
[Barratt Impulsiveness Scale] BIS-11 global score
Time Frame
At day 1
Title
Mini-SEA
Description
[Mini Social cognition and Emotional Assesment] Mini-SEA global score
Time Frame
At day 1
Title
STROOP
Description
[STROOP Test] STROOP global score
Time Frame
At day 1
Title
ECMP
Description
[Evaluation Comportementale dans la Maladie de Parkinson] ECMP answers
Time Frame
At day 1
Title
QUIP-RS
Description
[Questionnaire for Impulsive-Compulsive Disorders in Parkinson's Disease-Rating Scale] QUIP-RS global score
Time Frame
At day 1

10. Eligibility

Sex
All
Minimum Age & Unit of Time
40 Years
Maximum Age & Unit of Time
85 Years
Accepts Healthy Volunteers
Accepts Healthy Volunteers
Eligibility Criteria
Inclusion Criteria: All groups: Ability to give informed consent for study procedures Ability to understand study instructions and to realize the cognitive tasks Person with health insurance Patients: MMS>20 Absence of another neurological or psychiatric disease Presence of a caregiver We will recruit three groups of patients: diagnosed with behavioral variant frontotemporal dementia (bvFTD) according to the Rascovsky criteria (Rascovsky et al. 2011) diagnosed with idiopathic Parkinson's disease (Hughes et al. 1992) Sub-group 1: Parkinson's disease with Impulse Control Disorders (ICDs) Sub-group 2: Parkinson's disease without Impulse Control Disorders (ICDs) diagnosed with depression (Major Depressive Disorder, DSM-IV) Healthy age,sex, education-matched controls: MMS>27 Absence of neurological or psychiatric disease Exclusion Criteria: Standard contraindications to MRI Inability to understand study instructions Person mentioned in the article L.1121-5 to L. 1121-8 and L. 1122-12 of the French Public Health Code
Central Contact Person:
First Name & Middle Initial & Last Name or Official Title & Degree
Bénédicte M BATRANCOURT, PhD
Phone
(33-6) 60 44 79 79
Email
benedicte.batrancourt@upmc.fr
First Name & Middle Initial & Last Name or Official Title & Degree
Armelle RAMETTI-LACROUX, PhD
Phone
(33-1) 42 16 55 20
Email
armelle.ramettilacroux@icm-institute.org
Overall Study Officials:
First Name & Middle Initial & Last Name & Degree
Richard LEVY, MD, PhD
Organizational Affiliation
Institut National de la Santé Et de la Recherche Médicale, France
Official's Role
Principal Investigator
Facility Information:
Facility Name
ICM / Pitié-Salpêtrière Hospital AP-HP / CIC
City
Paris
ZIP/Postal Code
75013
Country
France
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Armelle RAMETTI-LACROUX, PhD
Phone
(33-1) 42 16 55 20
Email
armelle.ramettilacroux@icm-institute.org

12. IPD Sharing Statement

Plan to Share IPD
No

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Assessment of Apathy in a Real-life Situation, With a Video and Sensors-based System

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