Molecular Mediators of Physical Exercise and Carnosine Induced Effects in Patients With Preclinical and Early Stage Neurodegenerative Disease
Subjective Cognitive Impairment, Mild Cognitive Impairment, Parkinson Disease
About this trial
This is an interventional basic science trial for Subjective Cognitive Impairment
Eligibility Criteria
Inclusion Criteria:
- Signed informed consent
- Age 55 - 80 years
- Presence of Subjective Cognitive Impairment (SCI), Mild Cognitive Impairment (MCI) or early stage of Parkinson's Disease (Hoehn-Yahr 1st-2nd stage), assessed by experienced neurologist
Exclusion Criteria:
- Serious systemic cardiovascular, hepatic, renal disease, cancer
- Lack of compliance
Sites / Locations
- University Hospital Bratislava, Comenius University
- Biomedical Research Center, Slovak Academy of SciencesRecruiting
- Laboratory of Cognitive Neurophysiology, Institute of Physical Education, Health & Leisure Studies, National Cheng Kung University
Arms of the Study
Arm 1
Arm 2
Arm 3
Arm 4
Experimental
Experimental
Experimental
Experimental
exercise and carnosine supplementation
exercise and supplementation with placebo
stretching controls and carnosine supplementation
stretching controls and supplementation with placebo
exercise: participants will be subjected to 3 months supervised exercise intervention carnosine supplementation: participants will be instructed to take carnosine 2 times daily
exercise: participants will be subjected to 3 months supervised exercise intervention supplementation with placebo: participants will be instructed to take placebo 2 times daily
stretching controls: participants will be subjected to 3 months supervised stretching program carnosine supplementation: participants will be instructed to take carnosine 2 times daily
stretching controls: participants will be subjected to 3 months supervised stretching program supplementation with placebo: participants will be instructed to take placebo 2 times daily