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Blood Pressure Monitoring in High Risk Pregnancy to Improve the Detection and Monitoring of Hypertension (BUMP)

Primary Purpose

Pregnancy, High Risk, Pre-Eclampsia, Hypertension

Status
Completed
Phase
Not Applicable
Locations
United Kingdom
Study Type
Interventional
Intervention
Self-Monitoring of Blood Pressure
Sponsored by
University of Oxford
About
Eligibility
Locations
Arms
Outcomes
Full info

About this trial

This is an interventional health services research trial for Pregnancy, High Risk

Eligibility Criteria

18 Years - undefined (Adult, Older Adult)FemaleAccepts Healthy Volunteers

BUMP 1

Inclusion Criteria:

  • Participant is willing and able to give informed consent for participation in the trial
  • Pregnant woman, aged 18 years or above between 16+0 to 24+0 weeks
  • Able and willing to comply with trial requirements
  • Willing to allow her general practitioner and consultant, if appropriate, to be notified of participation in the trial
  • At higher risk for hypertension in pregnancy / pre-eclampsia defined as one or more of the following risk factors:
  • Age 40 years or older
  • Nulliparity
  • Pregnancy interval of more than 10 years
  • Family history of pre-eclampsia
  • Previous history of pre-eclampsia or gestational hypertension
  • Body mass index 30 kg/m2 or above at booking
  • Chronic kidney disease
  • Twin pregnancy
  • Diabetes (Type 1&2)
  • Autoimmune Disease (eg systemic lupus erythematosis or antiphospholipid disease)

Exclusion Criteria:

  • Chronic Hypertension

BUMP 2:

Inclusion Criteria:

• Women developing pregnancy hypertension previously randomised in BUMP 1 (regardless of gestation).

OR

  • Women with chronic hypertension (defined as sustained systolic BP≥140 mmHg and/or diastolic BP≥90 mmHg, present at booking or before 20 weeks' gestation, or receiving treatment outside pregnancy and/or at time of referral).
  • Recruited up to 37+0 weeks' gestation.

OR

  • Women with hypertension after 20 weeks' gestation (defined as sustained systolic BP≥140 mmHg and/or diastolic BP≥90 mmHg).
  • Recruited at 20+0 to 37+0 weeks' gestation.

AND

  • Participant is willing and able to give informed consent for participation in the trial.
  • Woman aged 18 years or above.
  • Willing to allow her general practitioner and consultant, if appropriate, to be notified of participation in the trial.

Exclusion criteria:

Anticipated inpatient admission considered likely to lead to imminent delivery (within the next 48 hours)

Sites / Locations

  • Buckinghamshire Healthcare NHS Trust
  • Birmingham Women's and Children's Hospital NHS Foundation Trust
  • Croydon Health Services NHS Trust
  • Barts Health NHS Trust
  • Kingston Hospital NHS Foundation Trust
  • Guy's and St Thomas' NHS Foundation Trust
  • King's College Hospital NHS Foundation Trust
  • Chelsea and Westminster Hospital NHS Foundation Trust
  • St George's University Hospitals NHS Foundation Trust
  • Manchester University NHS Foundation Trust
  • Oxford University Hospitals NHS Foundation Trust
  • The Royal Berkshire NHS Foundation Trust
  • The Royal Wolverhampton NHS Trust

Arms of the Study

Arm 1

Arm 2

Arm Type

Experimental

No Intervention

Arm Label

Self-Monitoring of Blood Pressure

Usual Care

Arm Description

BUMP 1: using a validated home blood pressure monitor at least 3 times a week to record blood pressure BUMP 2: using a validated home blood pressure monitor daily to record blood pressure Women in the intervention groups will be encouraged to use a simple mobile tele monitoring system.

Women randomised to usual care will continue to have all their BP monitoring completed by the clinical team at their antenatal assessments.

Outcomes

Primary Outcome Measures

Time from recruitment to diagnosis of raised blood pressure
Difference between groups in time from recruitment to recording of raised blood pressure by health care professional.
Mean systolic blood pressure
Difference in mean systolic blood pressure between usual care and self-monitoring group.

Secondary Outcome Measures

Severe hypertension
Difference between usual care and self-monitoring group in severe hypertension (systolic BP ≥160mmHg and/or or diastolic BP ≥110mmHg) (BUMP 1 and BUMP 2)
Serious maternal complications
Difference between usual care and self-monitoring group in serious maternal complications (pre-eclampsia, placental abruption, transient ischemic attack or stroke, pulmonary oedema, renal failure, blood transfusion), death (BUMP 1 and BUMP 2)
Onset of labour
Difference between usual care and self-monitoring group in onset of labour (BUMP 1 and BUMP 2)
Assessment of quality of life differences between arms
Difference between usual care and self-monitoring group in change in quality of life (measured using the EQ-5D-5L) (BUMP 1 and BUMP 2)
Assessment of quality of life differences between arms
Difference between usual care and self-monitoring group in change in quality of life (measured using the EQ-5D-5L (BUMP 1 and BUMP 2)
Stillbirth
Difference between usual care and self-monitoring group in number of stillbirths (BUMP 1 and BUMP 2)
Early neonatal deaths
Difference between usual care and self-monitoring group in number of early neonatal deaths (BUMP 1 BUMP 2)
Gestation at delivery
Difference between usual care and self-monitoring group in gestation at delivery (BUMP 1 and BUMP 2)
Mode of delivery
Difference between usual care and self-monitoring group in mode of delivery (BUMP 1 and BUMP 2)
Birth weight including centile
Difference between usual care and self-monitoring group in birth weight of the baby including centile (BUMP 1 and BUMP 2)
Small for gestational age infants
Difference between usual care and self-monitoring group in number of small for gestational age infants (<10th and <3rd centile) (BUMP 1 and BUMP 2)
Neonatal unit admissions
Difference between usual care and self-monitoring group in number of neonatal unit admissions including length of stay (BUMP 1 and BUMP 2)
Health behaviours
Difference between usual care and self-monitoring group in change in health behaviours (questionnaire) (BUMP 1 and BUMP 2)
Health behaviours
Difference between usual care and self-monitoring group in change in health behaviours (questionnaire) (BUMP 1 and BUMP 2)
Fidelity to monitoring schedule
Difference between usual care and self-monitoring group in fidelity to monitoring schedule (BUMP 1 and BUMP 2)
STAI-6 short form anxiety questionnaire
Difference between usual care and self-monitoring group in change in State trait anxiety inventory short form anxiety questionnaire (STAI-6 ) (BUMP 1 and BUMP 2)
STAI-6 short form anxiety questionnaire
Difference between usual care and self-monitoring group in change in STAI-6 short form anxiety questionnaire (BUMP 1 and BUMP 2)
Health service costs
Difference between usual care and self-monitoring group in health service costs. (BUMP 1 and BUMP 2)
Cost per quality-adjusted life year gained over trial period
Difference between usual care and self-monitoring group in cost per quality-adjusted life year gained over trial period (BUMP 1 and BUMP 2)
Qualitative
Qualitative data gathered from participating women and healthcare professionals (BUMP 1 and BUMP 2)
Mean diastolic blood pressure
Difference between usual care and self-monitoring group in mean diastolic blood pressure (BUMP 2)
Mean area under the blood pressure over time curve
Difference between usual care and self-monitoring group in mean area under the blood pressure curve (BUMP 2)
Mean proportion of readings above 140mmHg
Difference between usual care and self-monitoring group in mean proportion of readings above 140mmHg (BUMP 2)
Adherence to medication
Difference between usual care and self-monitoring group in change in adherence to medication (MARS) (BUMP 2)
Adherence to medication
Difference between usual care and self-monitoring group in change in adherence to medication (MARS) (BUMP 2)

Full Information

First Posted
October 24, 2017
Last Updated
June 1, 2022
Sponsor
University of Oxford
Collaborators
King's College London, Oxford University Hospitals NHS Trust, University of Southampton, University of Birmingham, Barts & The London NHS Trust, City, University of London, National Institute for Health Research, United Kingdom
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1. Study Identification

Unique Protocol Identification Number
NCT03334149
Brief Title
Blood Pressure Monitoring in High Risk Pregnancy to Improve the Detection and Monitoring of Hypertension
Acronym
BUMP
Official Title
Blood Pressure Monitoring in High Risk Pregnancy to Improve the Detection and Monitoring of Hypertension
Study Type
Interventional

2. Study Status

Record Verification Date
January 2022
Overall Recruitment Status
Completed
Study Start Date
November 22, 2017 (Actual)
Primary Completion Date
September 16, 2020 (Actual)
Study Completion Date
September 16, 2020 (Actual)

3. Sponsor/Collaborators

Responsible Party, by Official Title
Sponsor
Name of the Sponsor
University of Oxford
Collaborators
King's College London, Oxford University Hospitals NHS Trust, University of Southampton, University of Birmingham, Barts & The London NHS Trust, City, University of London, National Institute for Health Research, United Kingdom

4. Oversight

Studies a U.S. FDA-regulated Drug Product
No
Studies a U.S. FDA-regulated Device Product
No
Data Monitoring Committee
Yes

5. Study Description

Brief Summary
Raised blood pressure is a common problem in pregnancy. Raised blood pressure and pre-eclampsia affect about one in ten women and are a major cause of death and premature birth in the United Kingdom and worldwide. Many women have expressed an interest in monitoring their own blood pressure in between antenatal visits but there has been very little research to guide this. The investigators would like to know if the diagnosis and subsequent care of women with raised blood pressure can be improved if women were able to monitor their own blood pressure safely at home. This work will test whether optimising the diagnosis, monitoring and management of raised BP during pregnancy through self-monitoring of BP is effective, acceptable and cost-effective compared to usual care. The research team have being working with pregnant women, doctors and midwives to develop a simple and accurate method of self-monitoring of blood pressure in pregnancy. This randomised controlled trial will: Compare self-monitoring with usual care in women at higher risk of hypertension in pregnancy and assess if self-monitoring can identify raised blood pressure earlier. Compare self-monitoring with usual care for women with high blood pressure in pregnancy to see if it leads to lower blood pressure. Assess if self-monitoring is cost-effective. Pregnant women who chose to take part in these studies will be randomised to either usual care or asked to monitor their own blood pressure during their pregnancy in addition to their usual antenatal care.
Detailed Description
BUMP 1 will randomise 2262 women at higher risk of hypertension in pregnancy into usual care or self-monitoring. BUMP 2 will randomise 512 women with hypertension in pregnancy (including chronic hypertension) into usual care or self-monitoring. Women in BUMP 1 will move into BUMP 2 if they develop hypertension. Women will be recruited at approximately 15 hospitals in England over approximately 24 months. Women will be recruited from 20 weeks (BUMP 1) or early pregnancy(BUMP 2) and followed up until 2 months after birth.

6. Conditions and Keywords

Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
Pregnancy, High Risk, Pre-Eclampsia, Hypertension, Hypertension, Pregnancy-Induced

7. Study Design

Primary Purpose
Health Services Research
Study Phase
Not Applicable
Interventional Study Model
Parallel Assignment
Model Description
Note Women in BUMP 1 will transfer to BUMP 2 if they develop hypertension. Women in BUMP 2 can be randomised de novo or join from BUMP 1 maintaining their original randomisation. The enrolment number below therefore includes BUMP 1 (2262) plus BUMP 2 (512). Permission was granted by the ethics committee to continue recruitment passed the original sample size until the original planned end of recruitment date.
Masking
None (Open Label)
Allocation
Randomized
Enrollment
3042 (Actual)

8. Arms, Groups, and Interventions

Arm Title
Self-Monitoring of Blood Pressure
Arm Type
Experimental
Arm Description
BUMP 1: using a validated home blood pressure monitor at least 3 times a week to record blood pressure BUMP 2: using a validated home blood pressure monitor daily to record blood pressure Women in the intervention groups will be encouraged to use a simple mobile tele monitoring system.
Arm Title
Usual Care
Arm Type
No Intervention
Arm Description
Women randomised to usual care will continue to have all their BP monitoring completed by the clinical team at their antenatal assessments.
Intervention Type
Other
Intervention Name(s)
Self-Monitoring of Blood Pressure
Intervention Description
BUMP 1: Women randomised to the self-monitoring arm will be asked to measure blood pressures at least three times a week. They will perform two readings with a one minute interval and will be asked to act on the second reading if it falls outside their normal range thresholds described in their instructions, and aided by the tele monitoring system. BUMP 2: Women randomised to the self-monitoring arm will be asked to measure blood pressures daily. They will perform two readings with a one minute interval and will be asked to act on the second reading if it falls outside their normal range thresholds described in their instructions, aided by a tele monitoring system.
Primary Outcome Measure Information:
Title
Time from recruitment to diagnosis of raised blood pressure
Description
Difference between groups in time from recruitment to recording of raised blood pressure by health care professional.
Time Frame
From study entry to delivery i.e. up to approximately 25 weeks from recruitment
Title
Mean systolic blood pressure
Description
Difference in mean systolic blood pressure between usual care and self-monitoring group.
Time Frame
From study entry to delivery i.e. up to 40 weeks
Secondary Outcome Measure Information:
Title
Severe hypertension
Description
Difference between usual care and self-monitoring group in severe hypertension (systolic BP ≥160mmHg and/or or diastolic BP ≥110mmHg) (BUMP 1 and BUMP 2)
Time Frame
From study entry to delivery i.e. up to 40 weeks
Title
Serious maternal complications
Description
Difference between usual care and self-monitoring group in serious maternal complications (pre-eclampsia, placental abruption, transient ischemic attack or stroke, pulmonary oedema, renal failure, blood transfusion), death (BUMP 1 and BUMP 2)
Time Frame
From study entry to delivery i.e. up to 40 weeks
Title
Onset of labour
Description
Difference between usual care and self-monitoring group in onset of labour (BUMP 1 and BUMP 2)
Time Frame
At delivery
Title
Assessment of quality of life differences between arms
Description
Difference between usual care and self-monitoring group in change in quality of life (measured using the EQ-5D-5L) (BUMP 1 and BUMP 2)
Time Frame
From study entry to 30 weeks of pregnancy, or from study entry to 2 weeks following study entry if randomised after 30 weeks pregnancy
Title
Assessment of quality of life differences between arms
Description
Difference between usual care and self-monitoring group in change in quality of life (measured using the EQ-5D-5L (BUMP 1 and BUMP 2)
Time Frame
From study entry to 8 weeks postpartum i.e. up to 48 weeks
Title
Stillbirth
Description
Difference between usual care and self-monitoring group in number of stillbirths (BUMP 1 and BUMP 2)
Time Frame
At delivery
Title
Early neonatal deaths
Description
Difference between usual care and self-monitoring group in number of early neonatal deaths (BUMP 1 BUMP 2)
Time Frame
From delivery up to 28 days postpartum i.e. up to 4 weeks
Title
Gestation at delivery
Description
Difference between usual care and self-monitoring group in gestation at delivery (BUMP 1 and BUMP 2)
Time Frame
At delivery
Title
Mode of delivery
Description
Difference between usual care and self-monitoring group in mode of delivery (BUMP 1 and BUMP 2)
Time Frame
At delivery
Title
Birth weight including centile
Description
Difference between usual care and self-monitoring group in birth weight of the baby including centile (BUMP 1 and BUMP 2)
Time Frame
At delivery
Title
Small for gestational age infants
Description
Difference between usual care and self-monitoring group in number of small for gestational age infants (<10th and <3rd centile) (BUMP 1 and BUMP 2)
Time Frame
At delivery
Title
Neonatal unit admissions
Description
Difference between usual care and self-monitoring group in number of neonatal unit admissions including length of stay (BUMP 1 and BUMP 2)
Time Frame
From delivery up to 28 days postpartum i.e. up to 4 weeks
Title
Health behaviours
Description
Difference between usual care and self-monitoring group in change in health behaviours (questionnaire) (BUMP 1 and BUMP 2)
Time Frame
From study entry to 30 weeks of pregnancy, or from study entry to 2 weeks following study entry if randomised after 30 weeks pregnancy.
Title
Health behaviours
Description
Difference between usual care and self-monitoring group in change in health behaviours (questionnaire) (BUMP 1 and BUMP 2)
Time Frame
From study entry to 8 weeks postnatal i.e. up to 48 weeks
Title
Fidelity to monitoring schedule
Description
Difference between usual care and self-monitoring group in fidelity to monitoring schedule (BUMP 1 and BUMP 2)
Time Frame
From study entry to delivery i.e. up to 48 weeks
Title
STAI-6 short form anxiety questionnaire
Description
Difference between usual care and self-monitoring group in change in State trait anxiety inventory short form anxiety questionnaire (STAI-6 ) (BUMP 1 and BUMP 2)
Time Frame
From study entry to 30 weeks of pregnancy, or from study entry to 2 weeks following study entry if randomised after 30 weeks pregnancy.
Title
STAI-6 short form anxiety questionnaire
Description
Difference between usual care and self-monitoring group in change in STAI-6 short form anxiety questionnaire (BUMP 1 and BUMP 2)
Time Frame
From study entry to 8 weeks postnatal i.e. up to 48 weeks
Title
Health service costs
Description
Difference between usual care and self-monitoring group in health service costs. (BUMP 1 and BUMP 2)
Time Frame
From study entry to delivery i.e. up to 40 weeks
Title
Cost per quality-adjusted life year gained over trial period
Description
Difference between usual care and self-monitoring group in cost per quality-adjusted life year gained over trial period (BUMP 1 and BUMP 2)
Time Frame
From study entry to delivery i.e. up to 40 weeks
Title
Qualitative
Description
Qualitative data gathered from participating women and healthcare professionals (BUMP 1 and BUMP 2)
Time Frame
From study entry to 8 weeks postpartum i.e. up to 48 weeks
Title
Mean diastolic blood pressure
Description
Difference between usual care and self-monitoring group in mean diastolic blood pressure (BUMP 2)
Time Frame
From study entry to delivery i.e. up to 40 weeks
Title
Mean area under the blood pressure over time curve
Description
Difference between usual care and self-monitoring group in mean area under the blood pressure curve (BUMP 2)
Time Frame
From study entry to delivery i.e. up to 40 weeks
Title
Mean proportion of readings above 140mmHg
Description
Difference between usual care and self-monitoring group in mean proportion of readings above 140mmHg (BUMP 2)
Time Frame
From study entry to delivery i.e. up to 40 weeks
Title
Adherence to medication
Description
Difference between usual care and self-monitoring group in change in adherence to medication (MARS) (BUMP 2)
Time Frame
From study entry to 30 weeks of pregnancy, or from study entry to 2 weeks following study entry if randomised after 30 weeks pregnancy.
Title
Adherence to medication
Description
Difference between usual care and self-monitoring group in change in adherence to medication (MARS) (BUMP 2)
Time Frame
From study entry to 8 weeks postnatal i.e. up to 48 weeks

10. Eligibility

Sex
Female
Gender Based
Yes
Gender Eligibility Description
Pregnant Women
Minimum Age & Unit of Time
18 Years
Accepts Healthy Volunteers
Accepts Healthy Volunteers
Eligibility Criteria
BUMP 1 Inclusion Criteria: Participant is willing and able to give informed consent for participation in the trial Pregnant woman, aged 18 years or above between 16+0 to 24+0 weeks Able and willing to comply with trial requirements Willing to allow her general practitioner and consultant, if appropriate, to be notified of participation in the trial At higher risk for hypertension in pregnancy / pre-eclampsia defined as one or more of the following risk factors: Age 40 years or older Nulliparity Pregnancy interval of more than 10 years Family history of pre-eclampsia Previous history of pre-eclampsia or gestational hypertension Body mass index 30 kg/m2 or above at booking Chronic kidney disease Twin pregnancy Diabetes (Type 1&2) Autoimmune Disease (eg systemic lupus erythematosis or antiphospholipid disease) Exclusion Criteria: Chronic Hypertension BUMP 2: Inclusion Criteria: • Women developing pregnancy hypertension previously randomised in BUMP 1 (regardless of gestation). OR Women with chronic hypertension (defined as sustained systolic BP≥140 mmHg and/or diastolic BP≥90 mmHg, present at booking or before 20 weeks' gestation, or receiving treatment outside pregnancy and/or at time of referral). Recruited up to 37+0 weeks' gestation. OR Women with hypertension after 20 weeks' gestation (defined as sustained systolic BP≥140 mmHg and/or diastolic BP≥90 mmHg). Recruited at 20+0 to 37+0 weeks' gestation. AND Participant is willing and able to give informed consent for participation in the trial. Woman aged 18 years or above. Willing to allow her general practitioner and consultant, if appropriate, to be notified of participation in the trial. Exclusion criteria: Anticipated inpatient admission considered likely to lead to imminent delivery (within the next 48 hours)
Overall Study Officials:
First Name & Middle Initial & Last Name & Degree
Richard J McManus, PhD MBBS
Organizational Affiliation
University of Oxford
Official's Role
Principal Investigator
Facility Information:
Facility Name
Buckinghamshire Healthcare NHS Trust
City
Aylesbury
ZIP/Postal Code
HP21 8AL
Country
United Kingdom
Facility Name
Birmingham Women's and Children's Hospital NHS Foundation Trust
City
Birmingham
ZIP/Postal Code
B15 2TG
Country
United Kingdom
Facility Name
Croydon Health Services NHS Trust
City
London
ZIP/Postal Code
CR7 7YE
Country
United Kingdom
Facility Name
Barts Health NHS Trust
City
London
ZIP/Postal Code
E1 1BB
Country
United Kingdom
Facility Name
Kingston Hospital NHS Foundation Trust
City
London
ZIP/Postal Code
KT2 7QB
Country
United Kingdom
Facility Name
Guy's and St Thomas' NHS Foundation Trust
City
London
ZIP/Postal Code
SE1 7EH
Country
United Kingdom
Facility Name
King's College Hospital NHS Foundation Trust
City
London
ZIP/Postal Code
SE5 9RS
Country
United Kingdom
Facility Name
Chelsea and Westminster Hospital NHS Foundation Trust
City
London
ZIP/Postal Code
SW10 9NH
Country
United Kingdom
Facility Name
St George's University Hospitals NHS Foundation Trust
City
London
ZIP/Postal Code
SW17 0QT
Country
United Kingdom
Facility Name
Manchester University NHS Foundation Trust
City
Manchester
ZIP/Postal Code
M13 9WL
Country
United Kingdom
Facility Name
Oxford University Hospitals NHS Foundation Trust
City
Oxford
ZIP/Postal Code
OX6 2GG
Country
United Kingdom
Facility Name
The Royal Berkshire NHS Foundation Trust
City
Reading
ZIP/Postal Code
RG1 5AN
Country
United Kingdom
Facility Name
The Royal Wolverhampton NHS Trust
City
Wolverhampton
ZIP/Postal Code
WV10 0QP
Country
United Kingdom

12. IPD Sharing Statement

Plan to Share IPD
Yes
IPD Sharing Plan Description
Data are available from the authors upon reasonable request and with permission of the University of Oxford. Use of data will require approval by an independent review committee identified for this purpose and investigators requesting data will need to provide a written protocol including analysis plan and sign a data sharing/access agreement. Requests for Data Sharing should be directed to information.guardian@phc.ox.ac.uk.
IPD Sharing Time Frame
from 31st May 2023
IPD Sharing Access Criteria
Use of data will require approval by an independent review committee identified for this purpose and investigators requesting data will need to provide a written protocol including analysis plan and sign a data sharing/access agreement.
Citations:
PubMed Identifier
31980512
Citation
Dougall G, Franssen M, Tucker KL, Yu LM, Hinton L, Rivero-Arias O, Abel L, Allen J, Band RJ, Chisholm A, Crawford C, Green M, Greenfield S, Hodgkinson J, Leeson P, McCourt C, MacKillop L, Nickless A, Sandall J, Santos M, Tarassenko L, Velardo C, Wilson H, Yardley L, Chappell L, McManus RJ. Blood pressure monitoring in high-risk pregnancy to improve the detection and monitoring of hypertension (the BUMP 1 and 2 trials): protocol for two linked randomised controlled trials. BMJ Open. 2020 Jan 23;10(1):e034593. doi: 10.1136/bmjopen-2019-034593. Erratum In: BMJ Open. 2020 Aug 27;10(8):e034593corr1.
Results Reference
background
PubMed Identifier
35503346
Citation
Tucker KL, Mort S, Yu LM, Campbell H, Rivero-Arias O, Wilson HM, Allen J, Band R, Chisholm A, Crawford C, Dougall G, Engonidou L, Franssen M, Green M, Greenfield S, Hinton L, Hodgkinson J, Lavallee L, Leeson P, McCourt C, Mackillop L, Sandall J, Santos M, Tarassenko L, Velardo C, Yardley L, Chappell LC, McManus RJ; BUMP Investigators. Effect of Self-monitoring of Blood Pressure on Diagnosis of Hypertension During Higher-Risk Pregnancy: The BUMP 1 Randomized Clinical Trial. JAMA. 2022 May 3;327(17):1656-1665. doi: 10.1001/jama.2022.4712. Erratum In: JAMA. 2022 Jul 12;328(2):217.
Results Reference
result
PubMed Identifier
35503345
Citation
Chappell LC, Tucker KL, Galal U, Yu LM, Campbell H, Rivero-Arias O, Allen J, Band R, Chisholm A, Crawford C, Dougall G, Engonidou L, Franssen M, Green M, Greenfield S, Hinton L, Hodgkinson J, Lavallee L, Leeson P, McCourt C, Mackillop L, Sandall J, Santos M, Tarassenko L, Velardo C, Wilson H, Yardley L, McManus RJ; BUMP 2 Investigators. Effect of Self-monitoring of Blood Pressure on Blood Pressure Control in Pregnant Individuals With Chronic or Gestational Hypertension: The BUMP 2 Randomized Clinical Trial. JAMA. 2022 May 3;327(17):1666-1678. doi: 10.1001/jama.2022.4726.
Results Reference
result
PubMed Identifier
33262186
Citation
Hinton L, Hodgkinson J, Tucker KL, Rozmovits L, Chappell L, Greenfield S, McCourt C, Sandall J, McManus RJ. Exploring the potential for introducing home monitoring of blood pressure during pregnancy into maternity care: current views and experiences of staff-a qualitative study. BMJ Open. 2020 Dec 1;10(12):e037874. doi: 10.1136/bmjopen-2020-037874.
Results Reference
derived
PubMed Identifier
32748394
Citation
Ashworth DC, Maule SP, Stewart F, Nathan HL, Shennan AH, Chappell LC. Setting and techniques for monitoring blood pressure during pregnancy. Cochrane Database Syst Rev. 2020 Jul 23;8(8):CD012739. doi: 10.1002/14651858.CD012739.pub2.
Results Reference
derived

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Blood Pressure Monitoring in High Risk Pregnancy to Improve the Detection and Monitoring of Hypertension

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