Seasonal Affective Disorder and Visual Impairment
Seasonal Affective Disorder, Visual Impairment
About this trial
This is an interventional treatment trial for Seasonal Affective Disorder focused on measuring pupillometry, light therapy, visual impairment, melatonin, ipRGC
Eligibility Criteria
Inclusion Criteria:
Seasonal affective disorder. Visual impairment (Snellen visual acuity < 6/18) or visual field reduction (MD<10).
Exclusion Criteria:
Alcohol or drug abuse. Current or planned pregnancy. Other neuropsychiatric disorder. Antidepressant medication. Regular use of melatonin.
Sites / Locations
- Mental Health Center Copenhagen
Arms of the Study
Arm 1
Arm 2
Experimental
No Intervention
SAD
non-SAD
Persons with visual impairment and SAD are assessed by clinical interview, depression rating, diurnal saliva melatonin and cortisol and chromatic pupillometry during symptomatic winter phase and asymptomatic summer phase. Winter assessment is followed by a 6 week light therapy protocol ending with assessment of depression severity and repeated pupillometry.
Control participants with similar visual impairment but without SAD/sSAD are assessed by clinical interview, depression rating, diurnal saliva melatonin and cortisol and chromatic pupillometry in winter and summer.