Transperineal US on Basis of MRI in Female Pelvic Floor Dysfunction
Primary Purpose
Pelvic Floor Disorders
Status
Unknown status
Phase
Not Applicable
Locations
Study Type
Interventional
Intervention
transperineal ultrasound
Sponsored by
About this trial
This is an interventional diagnostic trial for Pelvic Floor Disorders
Eligibility Criteria
Inclusion Criteria:
- asmptomatic and symptomatic female Patients in child bearing period 40 days after vaginal delivery and cesarean section.
Exclusion Criteria:
- patients with previous pelvic floor surgery.
Sites / Locations
Arms of the Study
Arm 1
Arm Type
Experimental
Arm Label
Trans-perineal ultrasound
Arm Description
Transperineal ultrasonography is done by 2D ultrasound machine, curved probe is placed in the perineum, mid sagittal and axial views are obtained Then it's accuracy is assessed according to findings on dynamic pelvic MRI .
Outcomes
Primary Outcome Measures
role of trans-perineal ultrasound in diagnosis of pelvic floor dysfunction
accuracy of trans-perineal ultrasound in detection and assessment of female pelvic floor dysfunction
Secondary Outcome Measures
Full Information
1. Study Identification
Unique Protocol Identification Number
NCT03456310
Brief Title
Transperineal US on Basis of MRI in Female Pelvic Floor Dysfunction
Official Title
Role of Transperineal Ultrasonography on Basis of Dynamic Pelvic MRI in Diagnosis of Female Pelvic Floor Dysfunction.
Study Type
Interventional
2. Study Status
Record Verification Date
August 2018
Overall Recruitment Status
Unknown status
Study Start Date
September 2018 (Anticipated)
Primary Completion Date
February 2020 (Anticipated)
Study Completion Date
February 2022 (Anticipated)
3. Sponsor/Collaborators
Responsible Party, by Official Title
Principal Investigator
Name of the Sponsor
Assiut University
4. Oversight
Studies a U.S. FDA-regulated Drug Product
No
Studies a U.S. FDA-regulated Device Product
No
5. Study Description
Brief Summary
Pelvic floor failure is a common disorder that can seriously jeopardize a woman's quality of life by causing urinary and fecal incontinence, difficult defecation and pelvic pain. Multiple congenital and acquired risk factors are associated with pelvic floor failure, including altered collagen metabolism, female sex, vaginal delivery, menopause and advanced age. A complex variety of fascial and muscular lesions that range from stretching, insertion detachment, denervation atrophy and combinations of pelvic floor relaxation to pelvic organ prolapse may manifest in a single patient.
The prevalence of pelvic floor dysfunction increases with age. It is approximately 9.7% in child bearing period (20-39 yrs), while it reaches up to 49.7% by 80 yrs and older. Thorough preoperative assessment of pelvic floor failure is necessary to reduce the rate of relapse, which is reported to be as high as 30%.
MR imaging is a powerful tool that enables radiologists to comprehensively evaluate pelvic anatomic and functional abnormalities, thus helping surgeons provide appropriate treatment and avoid repeat operations.
Real time 2D trans-perineal ultrasound is emerging as an exciting new technique for pelvic floor assessment. It has advantage of providing a global view of the entire pelvic floor, from the symphysis to the ano-rectum, and includes the lower aspects of the levator ani muscle, in addition to its lower costs and greater accessibility; also sonographic imaging is more useful in the clinical environment, and generally better tolerated than magnetic resonance imaging.
Detailed Description
Patient: 135 female patients in child bearing period (20-39 yrs) will undergo trans-perineal ultrasound and dynamic pelvic MRI:
40 days after vaginal delivery or cesarean section for asymptomatic and symptomatic cases.
revision after six months for cases with sonongraphic or MRI findings. after obtaining an informed written consent and approval of the ethical committee of faculty of medicine of Assiut University.
Inclusion criteria: asymptomatic and symptomatic female Patients in child bearing period 40 days after vaginal delivery and cesarean section.
Exclusion criteria: patients with previous pelvic floor surgery.
Patient preparation
For trans-perineal US:
- Patient is positioned in dorsal lithotomy position, with the hips flexed and slightly abducted and after bladder and bowel emptying. The pelvic tilt can be improved by asking the patient to place their heels as close as possible to the buttocks and move hips towards the heels.
For MRI:
- Patient is positioned in supine position and using pelvic coil after bladder and bowel emptying.
Method:
trans-perineal US: B mode capable 2D ultrasound system with cine loop function, a 3.5-6.0 MHz curved array transducer. At women health hospital. A mid-sagittal and axial views is obtained by placing a transducer on the perineum (Parting of the labia can improve image quality).
The following measures will be obtained:
Hiatus diameter, bladder neck descent, and descent of other pelvic organs in relation to reference line (parallel to lower part of public bone).
Dynamic MRI:
Magnetic resonance (MR) imaging of the pelvic floor is a two-step process that includes:
analysis of anatomic damage on axial fast spin-echo (FSE) T2-weighted images. then sagittal and coronal (FSE) T2-weighted are obtained.
functional evaluation using sagittal dynamic single-shot T2-weighted sequences during straining and defecation to show descent of pelvic organs and pelvic floor relaxation or weakness.
6. Conditions and Keywords
Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
Pelvic Floor Disorders
7. Study Design
Primary Purpose
Diagnostic
Study Phase
Not Applicable
Interventional Study Model
Single Group Assignment
Masking
None (Open Label)
Allocation
N/A
Enrollment
135 (Anticipated)
8. Arms, Groups, and Interventions
Arm Title
Trans-perineal ultrasound
Arm Type
Experimental
Arm Description
Transperineal ultrasonography is done by 2D ultrasound machine, curved probe is placed in the perineum, mid sagittal and axial views are obtained Then it's accuracy is assessed according to findings on dynamic pelvic MRI .
Intervention Type
Diagnostic Test
Intervention Name(s)
transperineal ultrasound
Other Intervention Name(s)
dynamic pelvic MRI
Intervention Description
trans-perineal US: B mode capable 2D ultrasound system with cine loop function, a 3.5-6.0 MHz curved array transducer. A mid-sagittal and axial views is obtained by placing a transducer on the perineum (Parting of the labia can improve image quality).
Dynamic MRI:
Magnetic resonance (MR) imaging of the pelvic floor is a two-step process that includes:
analysis of anatomic damage on axial fast spin-echo (FSE) T2-weighted images. then sagittal and coronal (FSE) T2-weighted are obtained.
functional evaluation using sagittal dynamic single-shot T2-weighted sequences during straining and defecation.
Primary Outcome Measure Information:
Title
role of trans-perineal ultrasound in diagnosis of pelvic floor dysfunction
Description
accuracy of trans-perineal ultrasound in detection and assessment of female pelvic floor dysfunction
Time Frame
4 years
10. Eligibility
Sex
Female
Gender Based
Yes
Minimum Age & Unit of Time
20 Years
Maximum Age & Unit of Time
39 Years
Accepts Healthy Volunteers
Accepts Healthy Volunteers
Eligibility Criteria
Inclusion Criteria:
asmptomatic and symptomatic female Patients in child bearing period 40 days after vaginal delivery and cesarean section.
Exclusion Criteria:
patients with previous pelvic floor surgery.
12. IPD Sharing Statement
Learn more about this trial
Transperineal US on Basis of MRI in Female Pelvic Floor Dysfunction
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