Pragmatic Prehospital Group O Whole Blood Early Resuscitation Trial (PPOWER)
Hemorrhagic Shock
About this trial
This is an interventional treatment trial for Hemorrhagic Shock
Eligibility Criteria
Inclusion Criteria:
Injured patients being transport via an air medical service with hypotension (SBP =/< 90mmHg with tachycardia >108 OR SBP=/<70 without the tachycardia requirement)
Exclusion Criteria:
Age < 18 or > 89 years
Isolated fall from standing injury mechanism
Brain matter exposed or penetrating brain injury (GSW)
CPR > 5 mins with out ROSC
Isolated burns without evidence of traumatic injury
Isolated Drowning or Hanging
No Intravenous or Intraosseous access
Known prisoner or known pregnancy
Referral Hospital Admission
Wearing No PPOWER bracelet
Objection to study voiced by subject or family at scene
Sites / Locations
- University of Pittsburgh
Arms of the Study
Arm 1
Arm 2
Experimental
No Intervention
LTLR-WB
Standard Care
Receiving 2 units of low titer, leucocyte reduced, platelet replete whole blood initiated in the prehospital setting during air medical transport and continued (up to 6 units of whole blood followed by standard component resuscitation) thru the early in-hospital phase of care
Receiving standard prehospital air medical care and standard of care component (1:1:1) trauma resuscitation thru the early in-hospital phase of care