Restrictive vs. Liberal Oxygen Therapy for Trauma Patients (TRAUMOX)
Trauma, Wounds and Injuries
About this trial
This is an interventional prevention trial for Trauma focused on measuring Traumatic accident, Oxygen, Intensive Care, Emergency
Eligibility Criteria
Inclusion Criteria:
- Age ≥ 18 years, including fertile women*
- Blunt/Penetrating trauma patient
- Direct transfer from the scene of the accident to Rigshospitalets Traume Center
- Trauma team activation * There is no added risk for enrolment of fertile women as oxygen administration is approved for this group of patients.
Exclusion Criteria:
- Patients in cardiac arrest before/at admission
- Patients with a suspicion of smoke inhalation
- No hospital admission after initial treatment in trauma center
Sites / Locations
- Rigshospitalet
Arms of the Study
Arm 1
Arm 2
Active Comparator
Experimental
Liberal oxygen
Titrated oxygen
Liberal oxygen administration (to mimic current practice) for the first 24 hours without interruption. In the trauma bay and during intrahospital transportation this implies administration of a FiO2 of 1.0 for intubated patients and an oxygen flow on a non-rebreather with reservoir of 15 l/min for non-intubated patients. In the operating room, patients will receive a FiO2 of ≥ 0.8 to obtain a saturation of ≥ 98%. Patients admitted to the ICU/PACU/floor will receive and FiO2 of ≥ 0.8 or more to obtain a saturation of ≥ 98% when intubated and for non-intubated patients a non-rebreather with reservoir will be set to 15 l/min.
Titrated oxygen administration for the first 24 hours without interruption. Lowest dosage of oxygen possible in order to achieve a saturation of at least 94%, either using mechanical ventilation (intubated patients), a nasal cannula, a non-rebreather or nothing. A saturation above 94% shall not be aimed for using supplemental oxygen, and thus only patients without oxygen requirement shall have saturations above 94%. The intervention will only be interrupted in case the saturation becomes unmeasurable - if this happens, the treating physician shall treat the patient as he/she judges best fit. As soon as the saturation is measurable again, the intervention will resume. The treating physician must document and explain the situation.