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A Systematic Investigation of Phonetic Complexity Effects on Articulatory Motor Performance in Progressive Dysarthria

Primary Purpose

Amyotrophic Lateral Sclerosis, Parkinson Disease

Status
Completed
Phase
Not Applicable
Locations
United States
Study Type
Interventional
Intervention
Phonetic complexity effects on speech motor performance
Sponsored by
University of Missouri-Columbia
About
Eligibility
Locations
Arms
Outcomes
Full info

About this trial

This is an interventional basic science trial for Amyotrophic Lateral Sclerosis focused on measuring Dysarthria, Speech motor performance, Speech motor control, Speech kinematics

Eligibility Criteria

19 Years - 90 Years (Adult, Older Adult)All SexesAccepts Healthy Volunteers

Inclusion Criteria:

  1. May or may not have a neurological impairment.
  2. Age range of 19-90 years.
  3. Male or female.
  4. Provide written consent before any study specific procedures are performed.
  5. Have ability to comply with basic instructions.
  6. Monolingual English speaker.
  7. Have ability to partake in a 90 minute data collection.

Exclusion Criteria:

  1. Any speech, language, cognition, or hearing impairment prior to diagnosis of a neurodegenerative disease.
  2. Anyone not appropriate for study participation, as deemed by the principal investigator.

Sites / Locations

  • University of Kansas Medical Center
  • University of Missouri-Columbia

Arms of the Study

Arm 1

Arm Type

Other

Arm Label

Phonetic complexity effects

Arm Description

Conduct a comprehensive kinematic assessment using state-of-the art 3D speech tracking technology on individuals with ALS and PD as well as healthy talkers to identify articulatory motor disturbances as a function of phonetic complexity and dysarthria severity. Phonetic complexity will be experimentally manipulated using the consonant and vowel complexity classification system proposed by Kent (1992) that takes into account the underlying articulatory motor adjustments required to produce various speech sounds.

Outcomes

Primary Outcome Measures

Peak movement speed
Peak speed (millimeters/second) for each articulatory marker is the maximum value of the first-order derivative of each marker's Euclidean distance time-history.
Range of movement
The convex hull represents the smallest convex set containing all the points in the 3D motion path.
Duration
Word duration (seconds) is the time between onset and offset of movement for each word.
Spatiotemporal movement variability (STI)
STI is the most widely used metric to capture movement pattern variability during speech. To determine STI, the pattern of articulatory movements and the variability of that pattern over several repetitions of an utterance are examined.
Inter-articulator coordination
Spatiotemporal coupling relations between articulators will be derived from vertical movements of the articulators using a covariance measure.

Secondary Outcome Measures

Full Information

First Posted
July 10, 2018
Last Updated
May 16, 2022
Sponsor
University of Missouri-Columbia
Collaborators
National Institute on Deafness and Other Communication Disorders (NIDCD)
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1. Study Identification

Unique Protocol Identification Number
NCT03613038
Brief Title
A Systematic Investigation of Phonetic Complexity Effects on Articulatory Motor Performance in Progressive Dysarthria
Official Title
Understanding Communication and Cognitive Impairments in Neurodegenerative Disorders
Study Type
Interventional

2. Study Status

Record Verification Date
May 2022
Overall Recruitment Status
Completed
Study Start Date
July 15, 2017 (Actual)
Primary Completion Date
February 28, 2022 (Actual)
Study Completion Date
February 28, 2022 (Actual)

3. Sponsor/Collaborators

Responsible Party, by Official Title
Principal Investigator
Name of the Sponsor
University of Missouri-Columbia
Collaborators
National Institute on Deafness and Other Communication Disorders (NIDCD)

4. Oversight

Studies a U.S. FDA-regulated Drug Product
No
Studies a U.S. FDA-regulated Device Product
No
Data Monitoring Committee
No

5. Study Description

Brief Summary
The goal is to improve the fundamental knowledge about articulatory motor performance in people with Lou Gehrig's disease (also known as ALS) and Parkinson's disease (PD), in order to develop more sensitive assessments for progressive speech loss, which may lead to the improved timing of speech therapies.
Detailed Description
The long-term goal is to optimize dysarthria assessment by improving the early detection and tracking of articulatory performance in progressive dysarthrias. The short-term goal of the proposed cross-sectional study is to focus on ALS and PD and quantify articulatory kinematic performance as a function of phonetic complexity, which is experimentally manipulated based on theoretical principles of speech motor development. The research strategy is to use 3D electromagnetic articulography to examine phonetic complexity effects of single word stimuli at the articulatory kinematic level in 15 talkers each with preclinical, mild, and moderate dysarthria, relative to 45 controls. The central hypothesis is that as dysarthria severity increases the discrepancy in articulatory performance, indexed by movement speed, distance, coordination, and variability, between people with dysarthria and typical controls will significantly increase at a lower phonetic complexity level.

6. Conditions and Keywords

Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
Amyotrophic Lateral Sclerosis, Parkinson Disease
Keywords
Dysarthria, Speech motor performance, Speech motor control, Speech kinematics

7. Study Design

Primary Purpose
Basic Science
Study Phase
Not Applicable
Interventional Study Model
Single Group Assignment
Model Description
Two groups of participants i.e., participants with ALS or PD and healthy controls will be asked to repeat sentences that have target words with varying phonetic complexity.
Masking
None (Open Label)
Allocation
N/A
Enrollment
100 (Actual)

8. Arms, Groups, and Interventions

Arm Title
Phonetic complexity effects
Arm Type
Other
Arm Description
Conduct a comprehensive kinematic assessment using state-of-the art 3D speech tracking technology on individuals with ALS and PD as well as healthy talkers to identify articulatory motor disturbances as a function of phonetic complexity and dysarthria severity. Phonetic complexity will be experimentally manipulated using the consonant and vowel complexity classification system proposed by Kent (1992) that takes into account the underlying articulatory motor adjustments required to produce various speech sounds.
Intervention Type
Behavioral
Intervention Name(s)
Phonetic complexity effects on speech motor performance
Intervention Description
Use of 3D electromagnetic articulography to examine phonetic complexity effects of single word stimuli at the articulatory kinematic level in talkers each with preclinical, mild, and moderate dysarthria, relative to healthy controls.
Primary Outcome Measure Information:
Title
Peak movement speed
Description
Peak speed (millimeters/second) for each articulatory marker is the maximum value of the first-order derivative of each marker's Euclidean distance time-history.
Time Frame
Up to 3 months after enrollment
Title
Range of movement
Description
The convex hull represents the smallest convex set containing all the points in the 3D motion path.
Time Frame
Up to 3 months after enrollment
Title
Duration
Description
Word duration (seconds) is the time between onset and offset of movement for each word.
Time Frame
Up to 3 months after enrollment
Title
Spatiotemporal movement variability (STI)
Description
STI is the most widely used metric to capture movement pattern variability during speech. To determine STI, the pattern of articulatory movements and the variability of that pattern over several repetitions of an utterance are examined.
Time Frame
Up to 3 months after enrollment
Title
Inter-articulator coordination
Description
Spatiotemporal coupling relations between articulators will be derived from vertical movements of the articulators using a covariance measure.
Time Frame
Up to 3 months after enrollment

10. Eligibility

Sex
All
Minimum Age & Unit of Time
19 Years
Maximum Age & Unit of Time
90 Years
Accepts Healthy Volunteers
Accepts Healthy Volunteers
Eligibility Criteria
Inclusion Criteria: May or may not have a neurological impairment. Age range of 19-90 years. Male or female. Provide written consent before any study specific procedures are performed. Have ability to comply with basic instructions. Monolingual English speaker. Have ability to partake in a 90 minute data collection. Exclusion Criteria: Any speech, language, cognition, or hearing impairment prior to diagnosis of a neurodegenerative disease. Anyone not appropriate for study participation, as deemed by the principal investigator.
Overall Study Officials:
First Name & Middle Initial & Last Name & Degree
Mili Kuruvilla-Dugdale, PhD
Organizational Affiliation
University of Missouri-Columbia
Official's Role
Principal Investigator
Facility Information:
Facility Name
University of Kansas Medical Center
City
Fairway
State/Province
Kansas
ZIP/Postal Code
66205
Country
United States
Facility Name
University of Missouri-Columbia
City
Columbia
State/Province
Missouri
ZIP/Postal Code
65211
Country
United States

12. IPD Sharing Statement

Plan to Share IPD
Yes
IPD Sharing Plan Description
The data collected during this study, especially from people with ALS, cannot be easily duplicated so it will be readily shared with other researchers conducting motor speech research. In addition, few investigators have access to tongue tracking technology; therefore, making the tongue kinematic data available will allow other investigators to answer pertinent questions related to speech decline in progressive dysarthrias. Both the raw data and processed data will be made available to interested investigators but will be devoid of identifiers in order to protect the privacy of the participants. Data documentation such as descriptors and units will also be shared to prevent misinterpretation or confusion. Besides the data itself, the PI is willing to share the stimuli as requested by other investigators.
IPD Sharing Time Frame
Data will be ensured as soon as the study starts and even after the study ends.
IPD Sharing Access Criteria
Data will only be shared for research purposes.

Learn more about this trial

A Systematic Investigation of Phonetic Complexity Effects on Articulatory Motor Performance in Progressive Dysarthria

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