Low Intensity Focused Ultrasound for Learning and Memory (LIFUPMEM)
Brain Diseases, Memory Disorders, Learning Disabilities
About this trial
This is an interventional other trial for Brain Diseases focused on measuring Ultrasound, MRI, Learning, Memory, Cognitive Neural Prosthetic
Eligibility Criteria
Inclusion Criteria:
- Must be between 35-65 years of age
- Must be right handed
- English must be the dominant language
Exclusion Criteria:
- contraindications for MRI (e.g. metal implants, pregnancy)
- history of head injury sufficient to warrant medical attention
- history of alcohol abuse or dependence
- history of substance abuse or dependence
- history of major psychiatric illness requiring treatment
- history of cancer or other neoplastic syndromes
- history of major neurologic illness (e.g. epilepsy).
Sites / Locations
- University of California, Los Angeles
Arms of the Study
Arm 1
Arm 2
Experimental
Sham Comparator
MRI ultrasound sonication
Sham Ultrasound
Low Intensity focused ultrasound pulsation will be administered to participants while they are in the fMRI scanner. Functional and perfusion MR data will be collected before and after the sonication to allow for comparisons and investigation of pre and post sonication functional activation and connectivity.
While in the fMRI scanner, participants will have the ultrasound transducer attached to their head in the same manner as during the actual ultrasound sonication. However, during this portion of the experiment, the transducer will not be turned on. Previous, published experiments indicate that participants are unable to differentiate between when the transducer is on and off.