Effect of Changing Physiological Conditions on Myogenic Oscillations: Pilot Study
Vascular Diseases
About this trial
This is an interventional basic science trial for Vascular Diseases
Eligibility Criteria
Inclusion Criteria:
- Over 18 yrs of age
- Undergoing surgery in Moffitt-Long operating rooms
- Receiving general anesthesia
- Will have an intra-arterial catheter for clinical purposes
- Able to consent in english
Exclusion Criteria:
- Under 18 years of age
- unable to provide informed consent
- Pregnancy
Sites / Locations
- University of California San Francisco
Arms of the Study
Arm 1
Arm 2
Arm 3
Arm 4
Arm 5
Arm 6
Experimental
Experimental
Experimental
Experimental
Experimental
Experimental
Phenylephrine
Dexmedetomidine
Clevidipine
Calcium Chloride
tetanic stimulus
Increased venous pressure
Phenylephrine (100 ug/ml) infusion will be used to increase blood pressure by 20 mmHg
Dexmedetomidine infusion will be used to increase blood pressure by 20 mmHg
Clevidipine infusion will be used to increase blood pressure by 20 mmHg
Calcium Chloride will be administered to increase blood pressure and to increase blood calcium concentration
A 5 second 70 mA tetanic stimulus will be used to increase peripheral vascular tone
A 5 minute inflation of a noninvasive blood pressure cuff to 30 mmHg to increase venous pressure in the arm.