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Active clinical trials for "Vascular Diseases"

Results 1-10 of 958

The Effect of Chronic Remote Ischaemic Preconditioning on Blood Pressure in Older Adults

HypertensionVascular Diseases

The purpose of this study is to assess whether remote ischaemic conditioning, applied chronically, improves vascular health in older adults

Recruiting8 enrollment criteria

Music for Sleep After Stroke

StrokeCardiovascular Diseases5 more

Sleep difficulties are common following stroke yet effective evidence-based interventions for improving sleep in this population are lacking. A small number of studies have investigated the use of music listening as a way to improve sleep in adults with insomnia. This study aims to examine whether a mindful music-listening intervention can reduce subjective and objective insomnia symptoms and improve mood and fatigue post-stroke. Six adults with a clinical diagnosis of stroke presenting with an insomnia disorder will be recruited from stroke services within NHS Greater Glasgow and Clyde. A multiple baseline single case experimental design will be employed. Participants will be randomly allocated to a baseline phase of 7, 11 or 15 days, followed by a five-week mindful music-listening intervention incorporating sleep hygiene. Changes in subjective and objective sleep will be measured using questionnaires and actigraphy, respectively. Mood and fatigue will also be measured. The data will be analysed using visual inspection, Tau-U and multi-level modelling.

Recruiting11 enrollment criteria

BGC101 (EnEPC) Autologous Cell Therapy From Patient's Own Blood for Treatment of Critical Limb Ischemia...

Critical Limb IschemiaPeripheral Arterial Disease1 more

Evaluate the feasibility of an autologous cell preparation composed of a mixture of cells enriched for endothelial progenitor cells (EnEPCs) and multipotent adult hematopoietic stem/progenitor cells (HSPC) (BGC101), in the treatment of patients suffering from peripheral arterial disease (PAD) with critical limb ischemia (CLI) who have not responded to optimal pharmacological treatment or control of risk factors and/or had a revascularization failure, and do not have the option of further revascularization treatment.

Recruiting44 enrollment criteria

A Study Evaluating the Efficacy and Safety of Ralinepag to Improve Treatment Outcomes in PAH Patients...

PAHPulmonary Hypertension10 more

Study ROR-PH-301, ADVANCE OUTCOMES, is designed to assess the efficacy and safety of ralinepag when added to pulmonary arterial hypertension (PAH) standard of care or PAH-specific background therapy in subjects with World Health Organization (WHO) Group 1 PAH.

Recruiting32 enrollment criteria

Study Assessing the Efficacy and Safety of a Personalized Monotherapy Regimen of Brolucizumab in...

Macular Polypoidal Choroidal Vasculopathy (PCV)

This study is a 60-week, two-arm, randomized, open-label, active-controlled, multi-center study in patients with Polypoidal choroidal vasculopathy (PCV) who have not previously received anti-Vascular endothelial growth factor (VEGF) treatment.

Recruiting19 enrollment criteria

Sildenafil for Early Pulmonary Vascular Disease in Scleroderma

SclerodermaMildly Elevated Pulmonary Pressures

This is a Phase II randomized, double-blind, placebo-controlled trial of sildenafil in men and women with Scleroderma with mildly elevated pulmonary pressures (SSc-MEP) to determine whether sildenafil may be an effective treatment for SSc-MEP.

Recruiting17 enrollment criteria

For Patients With Ischemic Stroke, Clinically Study the Effectiveness and Safety of Butylphthalide....

StrokeCerebral Infarction5 more

This is a prospective, open, single-arm, the real world of clinical trials. The researchers plan to recruit 300 eligible patients. The main purpose of this study is to evaluate the effectiveness and safety of butylphthalide in the treatment of ischemic stroke, and to establish a population pharmacokinetic model of butylphthalide in elderly patients to explore its blood drug concentration. Correlation with its efficacy and adverse reactions.

Recruiting8 enrollment criteria

RADIANCE Continued Access Protocol

HypertensionHypertension3 more

RADIANCE CAP is a non-randomized study designed to allow for continued access to ultrasound renal denervation therapy via the Paradise System, and to allow for the on-going collection of safety and effectiveness data in subjects with uncontrolled hypertension despite the prescription of antihypertensive medications.

Recruiting14 enrollment criteria

Study of Ravulizumab in Pediatric Participants With HSCT-TMA

Thrombotic Microangiopathy

This study will evaluate the safety, efficacy, pharmacokinetics, and pharmacodynamics of ravulizumab administered by intravenous infusion to pediatric participants, from 1 month to < 18 years of age, with HSCT-TMA. The treatment period is 26 weeks, followed by a 26-week off-treatment follow-up period.

Recruiting21 enrollment criteria

The Efemoral Vascular Scaffold System (EVSS) for the Treatment of Patients With Symptomatic Peripheral...

Peripheral Arterial DiseaseVascular Diseases2 more

To evaluate the safety and performance of the EVSS in patients with symptomatic peripheral vascular disease from stenosis or occlusion of the femoropopliteal artery

Recruiting43 enrollment criteria
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