Emotion Study/Substudy: Flexible Brain Study
Aging, Emotions, Parkinson Disease
About this trial
This is an interventional prevention trial for Aging focused on measuring Emotional Aging, Neurofeedback
Eligibility Criteria
Inclusion Criteria: Young adults
- aged 18-35 years of age
- native English speaker
- at least 8th grade education
- generally physically and neurologically healthy as determined by the Health Demographics Screener
- eligible for MRI as determined by the MRI Eligibility Interview (including not being pregnant)
- scores within normal limits on a cognitive screener (MoCA)
- no indication of serious psychiatric disturbance including major depression (based on Mental Health Screener)
- willing and able to give informed consent
Inclusion Criteria: Older adults
- age 55-100 years of age
- native English speaker
- at least 8th grade education
- generally physically and neurologically healthy as determined by the Health Demographics Screener
- eligible for MRI as determined by the MRI Eligibility Interview
- no indication of dementia based on score of 30 or above on the Telephone Interview for Cognitive Status and nonimpaired score on the Montreal Cognitive Assessment (MoCA -- score of 22 and above)
- no indication of serious psychiatric disturbance including current major depression (based on Mental Health Screener)
- willing and able to give informed consent
Inclusion Criteria: Parkinson patients
- must meet criteria for diagnosis of idiopathic Parkinson disease according the UK Brain Bank by a movement trained neurologist.
- age 55-100 years of age
- native English speaker
- at least 8th grade education
- generally physically and neurologically healthy other than Parkinson disease
- eligible for MRI as determined by the MRI Eligibility Interview
- no indication of dementia based on cognitive screening measures (TICS -- score of 30 or above, and MoCa -- score of 22 and above)
- no indication of serious psychiatric disturbance including current major depression
- willing and able to give informed consent
Inclusion Criteria: Individuals with SCD and a family history of dementia or Alzheimer's disease
- age 55-100 years of age
- native English speaker
- at least 8th grade education
- generally physically and neurologically healthy as determined by the Health Demographics Screener
- eligible for MRI as determined by the MRI Eligibility Interview
- no indication of dementia based on score of 30 or above on the Telephone Interview for Cognitive Status and nonimpaired score on the Montreal Cognitive Assessment (MoCA -- score of 22 and above)
- no indication of serious psychiatric disturbance including current major depression (based on Mental Health Screener)
- willing and able to give informed consent
- community-dwelling with subjective report of cognitive complaints with scores >16 on the Cognitive Change Index (CCI-20)
- no evidence of dementia or mild cognitive impairment based on cognitive screening using the MoCA; scores must fall within normal limits for age, education, and sex
- no psychometric evidence of neuropsychological impairment on a modified Neuropsychological Battery from the NACC Unified Data Set, version 3
- score of 0 on the Global Clinic Dementia Rating (CDR) scale
- normal functional behavior in terms of daily activities, based on the Functional Activities Scale (FAQ)
- availability of an informant (over the phone) who can provide information about the participant's complaints using the informant version of the CCI-20, and corroborate normal activities of daily living on the FAQ and the CDR scale.
Exclusion Criteria:
- Pregnant or possibly pregnant
- Claustrophobia
- Large pieces of metal in the body, particularly in the face and neck.
- Piercings or metal implants that cannot be removed from the body
- Surgery on the brain or any prior serious brain damage or disease
- Dementia or severe cognitive disorders
- use of antipsychotics, sedatives, or other medications with significant anticholinergic properties (due to potential influence on memory)
- use of prescribed 'memory enhancing' medications such as Aricept or Namenda.
Sites / Locations
- University of Florida
Arms of the Study
Arm 1
Arm 2
Arm 3
Arm 4
Experimental
Experimental
Experimental
Active Comparator
Healthy Younger Group
Healthy Older Group
Parkinson Disease Group
Control Group
Participants will receive rt-fMRI training to increase anterior cingulate cortex activation.
Participants will receive rt-fMRI training to increase anterior cingulate cortex activation.
Participants will receive rt-fMRI training to increase anterior cingulate cortex activation.
Participants will receive rt-fMRI training to increase primary auditory cortex activation.