Efficacy of Chlorthalidone and Hydrochlorothiazide Combined With Amiloride on Blood Pressure in Primary Hypertension.
Hypertension
About this trial
This is an interventional treatment trial for Hypertension focused on measuring Hypertension, Treatment, Chlorthalidone, Hydrochlorothiazide, Amiloride
Eligibility Criteria
Inclusion Criteria:
- Adults (age 30 to 75 years).
- Diagnosis of primary hypertension based on ABPM (mean 24-h systolic BP ≥130 mmHg or mean 24-h diastolic BP ≥80 mmHg).
- No current use of antihypertensive medication.
Exclusion Criteria:
- Low life expectancy.
- Other indications for the use of diuretics.
- Intolerance or contraindications to the study drugs.
- Cardiovascular disease (heart failure, myocardial infarction or stroke).
- Secondary hypertension.
- Chronic kidney disease and / or abnormal renal function (creatinine >1.5 mg/dL).
- Hyperkalemia (serum potassium >5.5 mEq/L).
- Gout.
- Previous antihypertensive treatment with more than one drug.
- Systolic blood pressure ≥160 mmHg or diastolic blood pressure ≥100 mmHg measured through office blood pressure.
- Pregnancy or prospective pregnancy during the study.
- Lactating women.
Sites / Locations
- Hospital de Clinicas de Porto AlegreRecruiting
Arms of the Study
Arm 1
Arm 2
Arm 3
Arm 4
Experimental
Active Comparator
Active Comparator
Active Comparator
Chlorthalidone 25 mg + amiloride 20 mg
Chlorthalidone 25 mg + amiloride 10 mg
Hydrochlorothiazide 50 mg + amiloride 20 mg
Hydrochlorothiazide 50 mg + amiloride 10 mg
Chlorthalidone 25 mg plus amiloride 20 mg combined in a single capsule, taken orally in the morning, for 12 weeks.
Chlorthalidone 25 mg plus amiloride 10 mg combined in a single capsule, taken orally in the morning, for 12 weeks.
Hydrochlorothiazide 50 mg plus amiloride 20 mg combined in a single capsule, taken orally in the morning, for 12 weeks.
Hydrochlorothiazide 50 mg plus amiloride 10 mg combined in a single capsule, taken orally in the morning, for 12 weeks.