Evaluation of a Commercial Program on Weight Loss and Health Outcomes

This is an interventional treatment trial for Obesity Read More

Inclusion Criteria:

• Ages 18-75 years
• Body Mass Index (BMI) of 25 to 43
• Self-reported desire to lose weight
• Willing to discontinue any current over-the-counter (OTC) supplements not recommended/prescribed by physician, with the exception of multivitamins or other vitamin supplement
• Willing to follow recommendations required by study protocol
• Willing to include demographic information (e.g., ethnicity, income and education)
• Use of a personal iPhone on a daily basis
• Basic app skills
• Reliable home Wi-Fi access
• Ability to commit to attending up to 27 study visits in approximately 26 weeks

Exclusion Criteria

• Participants that are currently, or within the last 6 months, trying to lose weight by following guidelines (e.g., self-initiated programs) or a structured weight-loss program (e.g., at a medical center, university, commercial programs)
• Participants who were a member of WW within the past 12 months.
• Participants who are involved in any other research studies at this time (also, cannot join other research studies while in this study, over the next 6 months).
• Pregnant, nursing, or planning on becoming pregnant over the next 9 months.
• Weight loss of ≥ 5 kg in the previous 6 months.
• History of clinically diagnosed eating disorder.
• Reported health problems that make weight loss or unsupervised exercise unsafe or unreasonable (e.g., orthopedic limitations, heart problems)
• Untreated thyroid disease or any changes (type or dose) in thyroid medication in last 6 months.
• Taking any prescription medication with known effects on appetite or weight (e.g., oral steroids, weight loss medications such as Qysmia, Contrave, etc.) with the exception of subjects on a stable dose of SSRIs for 6 months
• Diuretic use, unless taken on a regular, daily basis for hypertension and on a stable dose for at least 30 days
• Chronic/inflammatory gastrointestinal disorders (irritable bowel syndrome is acceptable).
• History of heart problems (e.g., angina, bypass surgery, myocardial infarction, etc.) within previous 6 months.
• Resting systolic blood pressure >160 mmHg or resting diastolic blood pressure >100 mmHg
• Diagnosis of type 1 or type 2 diabetes
• Previous surgical procedure for weight loss.
• Major surgery within the previous 6 months.
• Presence of implanted cardiac defibrillator or pacemaker.
• History of cancer within past 5 years or current treatment for cancer (completely resected basal or squamous cell carcinoma acceptable if treatment completed more than 6 months prior to enrollment).
• Hospitalization for psychiatric disorders during the past 12 months
• Self-reported alcohol use > 7/week standard drinks for females and > 14/week for males or meets DSM-5 criteria for mild or greater, Alcohol Use Disorder
• Planning to relocate in the next 9 months