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Anticoagulation for Stroke Prevention In Patients With Recent Episodes of Perioperative AF After Noncardiac Surgery (ASPIRE-AF)

Primary Purpose

Stroke, Atrial Fibrillation

Status
Recruiting
Phase
Phase 4
Locations
International
Study Type
Interventional
Intervention
Non-vitamin K oral anticoagulant (NOAC)
Sponsored by
Population Health Research Institute
About
Eligibility
Locations
Arms
Outcomes
Full info

About this trial

This is an interventional prevention trial for Stroke focused on measuring Transient Atrial Fibrillation, Perioperative Atrial Fibrillation, Non-vitamin K Oral Anticoagulation, Noncardiac Surgery, PROBE Design

Eligibility Criteria

55 Years - undefined (Adult, Older Adult)All SexesDoes not accept healthy volunteers

Inclusion Criteria:

  1. noncardiac surgery with at least an overnight hospital admission after surgery in the last 35 days;
  2. ≥1 episode of clinically important perioperative AF during or after their surgery;
  3. sinus rhythm at the time of randomization; AND

  4. any of the following high-risk criteria:

    1. age 55-74 years, and having either known cardiovascular disease, recent major vascular surgery, or a CHA2DS2VASc score ≥3;OR
    2. age ≥75 years.

Exclusion Criteria:

  1. history of documented AF prior to noncardiac surgery;
  2. need for long-term systemic anticoagulation;
  3. ongoing need for long-term dual antiplatelet treatment;
  4. contraindication to oral anticoagulation;
  5. severe renal insufficiency (eGFR <30 ml/min);
  6. acute stroke in the past 3 months;
  7. underwent cardiac surgery in the past 3 months;
  8. history of nontraumatic intracranial, intraocular, or spinal bleeding;
  9. hemorrhagic disorder or bleeding diathesis;
  10. expected to be non-compliant with follow-up and/or study medications;
  11. known life expectancy less than 1 year due to concomitant disease;
  12. women who are pregnant, breastfeeding, or of childbearing potential who are not taking effective contraception; OR
  13. previously enrolled in the trial

Sites / Locations

  • Hospital Municipal Chivilcoy
  • Hospital Privado de Rosario
  • Sanatorio Cisma
  • Canberra Hospital
  • Royal Prince Alfred HospitalRecruiting
  • Concord Repatriation General HospitalRecruiting
  • John Hunter HospitalRecruiting
  • Westmead HospitalRecruiting
  • Wollongong Hospital
  • Wesley & Greenscopes Private Hospitals
  • Royal Brisbane and Women's Hospital
  • Monash Medical Centre
  • Royal Perth HospitalRecruiting
  • Instituto do Coração do Hospital das Clínicas da FMUSP
  • Hospital de Clinicas de Porto Alegre
  • University of Alberta HospitalRecruiting
  • Health Sciences Centre Winnipeg
  • Halifax InfirmaryRecruiting
  • Hamilton General HospitalRecruiting
  • St. Joseph's Healthcare HamiltonRecruiting
  • Juravinski HospitalRecruiting
  • Kingston General HospitalRecruiting
  • London Health Sciences Centre - University HospitalRecruiting
  • The Ottawa Hospital General CampusRecruiting
  • Niagara Health System - St. Catharine's SiteRecruiting
  • Centre Hospitalier de l'Université de MontréalRecruiting
  • Hôpital Fleurimont du Centre hospitalier universitaire de SherbrookeRecruiting
  • Royal University Hospital
  • Aarhus University Hospital
  • Hospital South West Jutland - University Hospital of Southern DenmarkRecruiting
  • Odense University HospitalRecruiting
  • Universitatsklinikum Leipzig
  • NU Hospitals
  • Amala Institute
  • Jehangir Clinical Development Centre
  • St. John's Medical College Hospital
  • NU Hospitals
  • Bangalore Baptist Hospital
  • JIPMER
  • Ruby Hall Clinic
  • Trivandrum Medical
  • Government Medical College
  • ASST Grande Ospedale Metropolitano Niguarda
  • Azienda Ospedaliera Nazionale SS. Antonio e Biagio e Cesare Arrigo
  • Fondazione IRCCS Ca'Granda Ospedale Maggiore PoliclinicoRecruiting
  • La Maddalena
  • Piacenza Ospedale
  • San Luigi Gonzaga
  • B and B HospitalRecruiting
  • Jeroen Bosch HospitalRecruiting
  • Noordwest ZiekenhuisgroepRecruiting
  • ZiekenhuisGroepTwente (ZGT)Recruiting
  • Ziekenhuis AmstellandRecruiting
  • Rijnstate HospitalRecruiting
  • Deventer ZiekenhuisRecruiting
  • Hospital Gelderse ValleiRecruiting
  • Martini HospitalRecruiting
  • Franciscus GasthuisRecruiting
  • Ikazia HospitalRecruiting
  • ETZ TilburgRecruiting
  • Dunedin Public Hospital
  • Waikato Hospital
  • Shifa International Hospital
  • Dow Medical University
  • Hospital de Mar
  • Vall d'Hebron Hospital
  • Hospital de la Santa Creu i Sant PauRecruiting
  • University Hospital Ramon y Cajal
  • Uppsala University
  • Blackpool Teaching Hospital
  • Liverpool Heart and Chest Hospital

Arms of the Study

Arm 1

Arm 2

Arm Type

Experimental

No Intervention

Arm Label

Non-vitamin K oral anticoagulant (NOAC)

No anticoagulation

Arm Description

Participants randomized to the intervention arm will be prescribed one of the following NOACs for 24 months, unless they are undergoing a procedure with an increased risk of bleeding, have an adverse event or low calculated creatinine clearance, or decide to discontinue their use.

Participants randomized to the control arm will not be prescribed an oral anticoagulant unless they develop a clear indication for one during follow-up (e.g., recurrent nonoperative AF). They can be newly prescribed or continue taking low dose aspirin or another single antiplatelet agent as per the protocol. This will be decided by the participant's physician.

Outcomes

Primary Outcome Measures

Incidence of Non-hemorrhagic stroke or systemic embolism
Incidence of vascular mortality, and non-fatal non-hemorrhagic stroke, myocardial infarction, peripheral arterial thrombosis, amputation, and symptomatic venous thromboembolism

Secondary Outcome Measures

Incidence of vascular mortality
Incidence of non-fatal, non-hemorrhagic stroke
Incidence of Myocardial infarction
Incidence of peripheral arterial thrombosis
Incidence of amputation
Incidence of symptomatic venous thromboembolism
Incidence of all-cause stroke
Incidence of all-cause mortality

Full Information

First Posted
March 22, 2019
Last Updated
September 28, 2023
Sponsor
Population Health Research Institute
Collaborators
Hamilton Health Sciences Corporation
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1. Study Identification

Unique Protocol Identification Number
NCT03968393
Brief Title
Anticoagulation for Stroke Prevention In Patients With Recent Episodes of Perioperative AF After Noncardiac Surgery
Acronym
ASPIRE-AF
Official Title
Anticoagulation for Stroke Prevention In Patients With Recent Episodes of Perioperative Atrial Fibrillation After Noncardiac Surgery - The ASPIRE-AF Trial
Study Type
Interventional

2. Study Status

Record Verification Date
September 2023
Overall Recruitment Status
Recruiting
Study Start Date
June 14, 2019 (Actual)
Primary Completion Date
September 2026 (Anticipated)
Study Completion Date
December 2026 (Anticipated)

3. Sponsor/Collaborators

Responsible Party, by Official Title
Sponsor
Name of the Sponsor
Population Health Research Institute
Collaborators
Hamilton Health Sciences Corporation

4. Oversight

Studies a U.S. FDA-regulated Drug Product
No
Studies a U.S. FDA-regulated Device Product
No
Data Monitoring Committee
No

5. Study Description

Brief Summary
Multinational, investigator-initiated study of oral anticoagulation versus no anticoagulation for the prevention of stroke and other adverse cardiovascular events in patients with transient perioperative atrial fibrillation after noncardiac surgery and additional stroke risk factors.
Detailed Description
ASPIRE-AF is a prospective, randomized, open-label trial of non-vitamin K oral anticoagulants (NOACs) versus no oral anticoagulation in patients with transient perioperative atrial fibrillation and additional stroke factors after noncardiac surgery. The primary objective is to assess the effects of NOACs on the co-primary composite outcomes of 1. non-hemorrhagic stroke and systemic embolism, and 2. vascular mortality, and non-fatal non-hemorrhagic stroke, myocardial infarction, peripheral arterial thrombosis, amputation, and symptomatic venous thromboembolism 24 months after randomization.

6. Conditions and Keywords

Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
Stroke, Atrial Fibrillation
Keywords
Transient Atrial Fibrillation, Perioperative Atrial Fibrillation, Non-vitamin K Oral Anticoagulation, Noncardiac Surgery, PROBE Design

7. Study Design

Primary Purpose
Prevention
Study Phase
Phase 4
Interventional Study Model
Parallel Assignment
Model Description
Prospective, randomized, open-label clinical trial with blinded outcome assessment
Masking
Outcomes Assessor
Allocation
Randomized
Enrollment
2800 (Anticipated)

8. Arms, Groups, and Interventions

Arm Title
Non-vitamin K oral anticoagulant (NOAC)
Arm Type
Experimental
Arm Description
Participants randomized to the intervention arm will be prescribed one of the following NOACs for 24 months, unless they are undergoing a procedure with an increased risk of bleeding, have an adverse event or low calculated creatinine clearance, or decide to discontinue their use.
Arm Title
No anticoagulation
Arm Type
No Intervention
Arm Description
Participants randomized to the control arm will not be prescribed an oral anticoagulant unless they develop a clear indication for one during follow-up (e.g., recurrent nonoperative AF). They can be newly prescribed or continue taking low dose aspirin or another single antiplatelet agent as per the protocol. This will be decided by the participant's physician.
Intervention Type
Drug
Intervention Name(s)
Non-vitamin K oral anticoagulant (NOAC)
Other Intervention Name(s)
Apixaban, Dabigatran, Edoxaban, Rivaroxaban
Intervention Description
Participants randomized to the intervention arm will be prescribed one of the following NOACs for 24 months: edoxaban 60 mg daily (dose reduction to 30 mg, if applicable), apixaban 5 mg twice daily (dose reduction to 2.5 mg, if applicable), dabigatran 110 mg twice daily, or rivaroxaban 20 mg daily (dose reduction to 15 mg, if applicable). The choice of NOAC will be left up to the participant's prescribing physician.
Primary Outcome Measure Information:
Title
Incidence of Non-hemorrhagic stroke or systemic embolism
Time Frame
Up to 24 months, until final follow-up
Title
Incidence of vascular mortality, and non-fatal non-hemorrhagic stroke, myocardial infarction, peripheral arterial thrombosis, amputation, and symptomatic venous thromboembolism
Time Frame
Up to 24 months, until final follow-up
Secondary Outcome Measure Information:
Title
Incidence of vascular mortality
Time Frame
Up to 24 months, until final follow-up
Title
Incidence of non-fatal, non-hemorrhagic stroke
Time Frame
Up to 24 months, until final follow-up
Title
Incidence of Myocardial infarction
Time Frame
Up to 24 months, until final follow-up
Title
Incidence of peripheral arterial thrombosis
Time Frame
Up to 24 months, until final follow-up
Title
Incidence of amputation
Time Frame
Up to 24 months, until final follow-up
Title
Incidence of symptomatic venous thromboembolism
Time Frame
Up to 24 months, until final follow-up
Title
Incidence of all-cause stroke
Time Frame
Up to 24 months, until final follow-up
Title
Incidence of all-cause mortality
Time Frame
Up to 24 months, until final follow-up
Other Pre-specified Outcome Measures:
Title
Incidence of composite of life-threatening, major, and critical organ bleeding
Description
Safety objective, measured as previously done in the MANAGE trial
Time Frame
Up to 24 months, until final follow-up
Title
Incidence of major bleeding
Description
Safety objective, measured according to the ISTH criteria
Time Frame
Up to 24 months, until final follow-up
Title
Incidence of hemorrhagic stroke
Description
Safety objective
Time Frame
Up to 24 months, until final follow-up
Title
Hospitalization for vascular causes
Description
Tertiary Objective
Time Frame
Up to 24 months, until final follow-up
Title
Hospitalization for all causes
Description
Tertiary Objective
Time Frame
Up to 24 months, until final follow-up

10. Eligibility

Sex
All
Minimum Age & Unit of Time
55 Years
Accepts Healthy Volunteers
No
Eligibility Criteria
Inclusion Criteria: noncardiac surgery with at least an overnight hospital admission after surgery in the last 35 days; ≥1 episode of clinically important perioperative AF during or after their surgery; sinus rhythm at the time of randomization; AND any of the following high-risk criteria: age 55-74 years, and having either known cardiovascular disease, recent major vascular surgery, or a CHA2DS2VASc score ≥3;OR age ≥75 years. Exclusion Criteria: history of documented AF prior to noncardiac surgery; need for long-term systemic anticoagulation; ongoing need for long-term dual antiplatelet treatment; contraindication to oral anticoagulation; severe renal insufficiency (eGFR <30 ml/min); acute stroke in the past 3 months; underwent cardiac surgery in the past 3 months; history of nontraumatic intracranial, intraocular, or spinal bleeding; hemorrhagic disorder or bleeding diathesis; expected to be non-compliant with follow-up and/or study medications; known life expectancy less than 1 year due to concomitant disease; women who are pregnant, breastfeeding, or of childbearing potential who are not taking effective contraception; OR previously enrolled in the trial
Central Contact Person:
First Name & Middle Initial & Last Name or Official Title & Degree
Cassie McDonald
Phone
1-905-594-0560
Email
aspireaf@phri.ca
Overall Study Officials:
First Name & Middle Initial & Last Name & Degree
David Conen, MD, MPH
Organizational Affiliation
Population Health Research Institute
Official's Role
Principal Investigator
First Name & Middle Initial & Last Name & Degree
PJ Devereaux, MD, PhD
Organizational Affiliation
Population Health Research Institute
Official's Role
Study Chair
Facility Information:
Facility Name
Hospital Municipal Chivilcoy
City
Chivilcoy
ZIP/Postal Code
B6620
Country
Argentina
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Pablo Fernandez, MD
Facility Name
Hospital Privado de Rosario
City
Santa Fe
ZIP/Postal Code
S2000GAP
Country
Argentina
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Carlos Dumont, MD
Facility Name
Sanatorio Cisma
City
Tucuman
ZIP/Postal Code
T4000
Country
Argentina
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Guillermo Isa Messa, MD
Facility Name
Canberra Hospital
City
Garran
State/Province
Australian Capital Territory
ZIP/Postal Code
2605
Country
Australia
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Walter Abhayaratna, MD
Facility Name
Royal Prince Alfred Hospital
City
Camperdown
State/Province
New South Wales
ZIP/Postal Code
2050
Country
Australia
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Sanjay Patel, MD
Facility Name
Concord Repatriation General Hospital
City
Concord
State/Province
New South Wales
ZIP/Postal Code
2139
Country
Australia
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
David Brieger, MD
Facility Name
John Hunter Hospital
City
Newcastle
State/Province
New South Wales
ZIP/Postal Code
2305
Country
Australia
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Aaron Sverdlov, MD
Facility Name
Westmead Hospital
City
Westmead
State/Province
New South Wales
ZIP/Postal Code
2145
Country
Australia
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Clara Chow, MD
Facility Name
Wollongong Hospital
City
Wollongong
State/Province
New South Wales
ZIP/Postal Code
2500
Country
Australia
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Astin Lee, MD
Facility Name
Wesley & Greenscopes Private Hospitals
City
Brisbane
State/Province
Queensland
ZIP/Postal Code
4064
Country
Australia
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
David Colquhoun, MD
Facility Name
Royal Brisbane and Women's Hospital
City
Herston
State/Province
Queensland
ZIP/Postal Code
4029
Country
Australia
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
John Atherton, MD
Facility Name
Monash Medical Centre
City
Clayton
State/Province
Victoria
ZIP/Postal Code
3168
Country
Australia
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Stephen Nicholls, MD
Facility Name
Royal Perth Hospital
City
Perth
State/Province
Western Australia
ZIP/Postal Code
6000
Country
Australia
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Graham Hillis, MD
Facility Name
Instituto do Coração do Hospital das Clínicas da FMUSP
City
Cerqueira César
ZIP/Postal Code
05403-900
Country
Brazil
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Carlos Serrano, MD
Facility Name
Hospital de Clinicas de Porto Alegre
City
Porto Alegre
ZIP/Postal Code
90035-903
Country
Brazil
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Carisi Polanczyk, MD
Facility Name
University of Alberta Hospital
City
Edmonton
State/Province
Alberta
ZIP/Postal Code
T6G 2B7
Country
Canada
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Finlay McAlister, MD
Facility Name
Health Sciences Centre Winnipeg
City
Winnipeg
State/Province
Manitoba
ZIP/Postal Code
R3A 1R9
Country
Canada
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Sadeesh Srinathan, MD
Facility Name
Halifax Infirmary
City
Halifax
State/Province
Nova Scotia
ZIP/Postal Code
B3H 3A6
Country
Canada
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Kim Styles, MD
Facility Name
Hamilton General Hospital
City
Hamilton
State/Province
Ontario
ZIP/Postal Code
L8L 2X2
Country
Canada
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Mohamed Panju, MD
Facility Name
St. Joseph's Healthcare Hamilton
City
Hamilton
State/Province
Ontario
ZIP/Postal Code
L8N 4A6
Country
Canada
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Vikas Tandon, MD
Facility Name
Juravinski Hospital
City
Hamilton
State/Province
Ontario
ZIP/Postal Code
L8V 1C3
Country
Canada
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Ameen Patel, MD
Facility Name
Kingston General Hospital
City
Kingston
State/Province
Ontario
ZIP/Postal Code
K7L 2V7
Country
Canada
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Michael McMullen, MD
Facility Name
London Health Sciences Centre - University Hospital
City
London
State/Province
Ontario
ZIP/Postal Code
N6A 5A5
Country
Canada
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Marko Mrkobrada, MD
Facility Name
The Ottawa Hospital General Campus
City
Ottawa
State/Province
Ontario
ZIP/Postal Code
K1H 8L6
Country
Canada
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
James Villeneuve, MD
Facility Name
Niagara Health System - St. Catharine's Site
City
St. Catharines
State/Province
Ontario
ZIP/Postal Code
L2S 0A9
Country
Canada
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Leonard Blair, MD
Facility Name
Centre Hospitalier de l'Université de Montréal
City
Montréal
State/Province
Quebec
ZIP/Postal Code
H2X 3E4
Country
Canada
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Isabelle Greiss, MD
Facility Name
Hôpital Fleurimont du Centre hospitalier universitaire de Sherbrooke
City
Sherbrooke
State/Province
Quebec
ZIP/Postal Code
J1H 5H3
Country
Canada
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Félix Ayala-Paredes, MD
Facility Name
Royal University Hospital
City
Saskatoon
State/Province
Saskatchewan
ZIP/Postal Code
S7N 0W8
Country
Canada
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Michael Prystajecky, MD
Facility Name
Aarhus University Hospital
City
Aarhus
ZIP/Postal Code
8200
Country
Denmark
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Erik Grove, MD
Facility Name
Hospital South West Jutland - University Hospital of Southern Denmark
City
Esbjerg
ZIP/Postal Code
6700
Country
Denmark
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Axel Brandes, MD
Facility Name
Odense University Hospital
City
Odense
ZIP/Postal Code
5000
Country
Denmark
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Axel Brandes, MD
Facility Name
Universitatsklinikum Leipzig
City
Leipzig
ZIP/Postal Code
04103
Country
Germany
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Rolf Wachter, MD
Facility Name
NU Hospitals
City
Bangalore
State/Province
Karnataka
ZIP/Postal Code
560010
Country
India
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Pramod Krishnappa, MD
Facility Name
Amala Institute
City
Thrissur
State/Province
Kerala
ZIP/Postal Code
680555
Country
India
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Kishore Puthezhath, MD
Facility Name
Jehangir Clinical Development Centre
City
Pune
State/Province
Maharashtra
ZIP/Postal Code
411001
Country
India
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Ajit Mehta, MD
Facility Name
St. John's Medical College Hospital
City
Bangalore
ZIP/Postal Code
560034
Country
India
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Joe Cherian, MD
Facility Name
NU Hospitals
City
Bengaluru
ZIP/Postal Code
560010
Country
India
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Pramod Krishnappa, MD
Facility Name
Bangalore Baptist Hospital
City
Bengaluru
ZIP/Postal Code
560024
Country
India
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Joel Jacob Chakravarthy, MD
Facility Name
JIPMER
City
Pondicherry
ZIP/Postal Code
605006
Country
India
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Adinarayanan Sethurmachandran, MD
Facility Name
Ruby Hall Clinic
City
Pune
ZIP/Postal Code
411057
Country
India
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Jagdish Hiremath, MD
Facility Name
Trivandrum Medical
City
Thiruvananthapuram
ZIP/Postal Code
695011
Country
India
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Prem Menon, MD
Facility Name
Government Medical College
City
Trivandrum
ZIP/Postal Code
695011
Country
India
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Prem Menon, MD
Facility Name
ASST Grande Ospedale Metropolitano Niguarda
City
Milano
State/Province
Milan
ZIP/Postal Code
20162
Country
Italy
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Matteo Baroni, MD
Facility Name
Azienda Ospedaliera Nazionale SS. Antonio e Biagio e Cesare Arrigo
City
Alessandria
ZIP/Postal Code
15121
Country
Italy
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Gabriele Colò, MD
Facility Name
Fondazione IRCCS Ca'Granda Ospedale Maggiore Policlinico
City
Milan
ZIP/Postal Code
20122
Country
Italy
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Giuseppe Ristagno, MD
Facility Name
La Maddalena
City
Palermo
ZIP/Postal Code
90146
Country
Italy
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Salvatore D'Arpa, MD
Facility Name
Piacenza Ospedale
City
Piacenza
ZIP/Postal Code
29121
Country
Italy
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Maria Bolognesi, MD
Facility Name
San Luigi Gonzaga
City
Turin
ZIP/Postal Code
10043
Country
Italy
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Pietro Caironi, MD
Facility Name
B and B Hospital
City
Lalitpur
ZIP/Postal Code
44700
Country
Nepal
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Rajib Rajbhandari, MD
Facility Name
Jeroen Bosch Hospital
City
's-Hertogenbosch
ZIP/Postal Code
5223
Country
Netherlands
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Jacob Van Eck, MD
Facility Name
Noordwest Ziekenhuisgroep
City
Alkmaar
ZIP/Postal Code
1815
Country
Netherlands
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Stefan Timmer, MD
Facility Name
ZiekenhuisGroepTwente (ZGT)
City
Almelo
ZIP/Postal Code
7609
Country
Netherlands
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Lambertus Pos, MD
Facility Name
Ziekenhuis Amstelland
City
Amstelveen
ZIP/Postal Code
1186
Country
Netherlands
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Freerk Broeyer, MD
Facility Name
Rijnstate Hospital
City
Arnhem
ZIP/Postal Code
6815
Country
Netherlands
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Ron Pisters, MD
Facility Name
Deventer Ziekenhuis
City
Deventer
ZIP/Postal Code
7416
Country
Netherlands
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Ype Tuininga, MD
Facility Name
Hospital Gelderse Vallei
City
Ede
ZIP/Postal Code
6716
Country
Netherlands
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Thomas Oosterhof, MD
Facility Name
Martini Hospital
City
Groningen
ZIP/Postal Code
9728
Country
Netherlands
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Robert Tieleman, MD
Facility Name
Franciscus Gasthuis
City
Rotterdam
ZIP/Postal Code
3045
Country
Netherlands
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Peter Nierop, MD
Facility Name
Ikazia Hospital
City
Rotterdam
ZIP/Postal Code
3083
Country
Netherlands
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Stieneke Zoet-Nugteren, MD
Facility Name
ETZ Tilburg
City
Tilburg
ZIP/Postal Code
5022
Country
Netherlands
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Walter Hermans, MD
Facility Name
Dunedin Public Hospital
City
Dunedin
ZIP/Postal Code
9016
Country
New Zealand
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
James Pemberton, MD
Facility Name
Waikato Hospital
City
Hamilton
ZIP/Postal Code
3204
Country
New Zealand
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Martin Stiles, MD
Facility Name
Shifa International Hospital
City
Islamabad
Country
Pakistan
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Saeed Ullah Shah, MD
Facility Name
Dow Medical University
City
Karachi
Country
Pakistan
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Muhammad Tariq Farman, MD
Facility Name
Hospital de Mar
City
Barcelona
ZIP/Postal Code
08003
Country
Spain
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Sandra Beltran de Heredia Marrodan, MD
Facility Name
Vall d'Hebron Hospital
City
Barcelona
ZIP/Postal Code
08014
Country
Spain
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Montserrat Ribas Ball, MD
Facility Name
Hospital de la Santa Creu i Sant Pau
City
Barcelona
ZIP/Postal Code
08025
Country
Spain
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Jose M Guerra, MD
Facility Name
University Hospital Ramon y Cajal
City
Madrid
ZIP/Postal Code
28034
Country
Spain
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Jesus Alvarez Garcia, MD
Facility Name
Uppsala University
City
Uppsala
ZIP/Postal Code
751 85
Country
Sweden
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Claes Held, MD
First Name & Middle Initial & Last Name & Degree
Gorav Batra, MD
Facility Name
Blackpool Teaching Hospital
City
Blackpool
State/Province
Lancashire
ZIP/Postal Code
FY3 8NR
Country
United Kingdom
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Alex Blackmore, MD
Facility Name
Liverpool Heart and Chest Hospital
City
Liverpool
ZIP/Postal Code
L14 3PE
Country
United Kingdom
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Michael Shackcloth, MD

12. IPD Sharing Statement

Plan to Share IPD
No

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Anticoagulation for Stroke Prevention In Patients With Recent Episodes of Perioperative AF After Noncardiac Surgery

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