Comparison of Gastrointestinal Motility in Healthy Children and Children With Constipation
Constipation, Childhood Acute Lymphoblastic Leukemia, Neurofibromatosis 1
About this trial
This is an interventional diagnostic trial for Constipation
Eligibility Criteria
Inclusion Criteria applicable to all participants:
• Children between 7-17 years of age where permission is granted for the participation by habitable parents with custody of the child. In case of joint custody, permission must be obtained from both parents.
Inclusion criteria applicable only to healthy participants:
• Gastrointestinal healthy children without chronic constipation
Inclusion criteria applicable only to constipated participants:
• Chronic constipation defined by Rom IV criteria, which is a diagnostic score for chronic constipation
Inclusion criteria applicable only to children in vincristine treatment:
• Children with cancer in treatment with vincristine
Inclusion criteria applicable only to patients with NF1:
• Diagnosis of NF1 with gastrointestinal symptoms
Exclusion Criteria:
- Children with parents who are unable to understand the given particpant's information
- Children with known dysregulated metabolic disease
- Previously major intra-abdominal surgery
- CNS surgery
- Other treatment-requiring gastrointestinal disorder
- Systemic steroid treatment within the last week
- Children with difficulty swallowing
- Children with known gastrointestinal obstruction or perforation
- Acute infections
- Diagnosed malabsorption including bile acid malabsorption
- Menarche in girls
Sites / Locations
- Aarhus University HospitalRecruiting
Arms of the Study
Arm 1
Experimental
Children being investigated with 3D-transit
4 groups of each 20 children will be investigated with respectively one or two capsules: Healthy children (1) Children with chronic constipation (2) Children with neurofibromatosis type 1 (2) Children with cancer receiving treatment with Vincristine (1)