Iron and Vitamin A in School Children (IronVitA)
Anemia, Iron Deficiency, Vitamin A Deficiency, Cognitive Development
About this trial
This is an interventional prevention trial for Anemia, Iron Deficiency focused on measuring Intermittent Iron supplementation, Vitamin A, Cognitive Development, Anemia
Eligibility Criteria
Inclusion Criteria:
- One or both their parents signed informed consent form;
- Their parents planned to stay during the period of the study (for the full academic year) in the kebele; and
- They accept of the intervention package including blood draw and home visits. School children with severe anemia (Hb concentration <80 g/L) will be treated by conventional protocol for three months at nearby health centres. After reassessing their haemoglobin concentrations, they can be assigned to their intervention groups if they become eligible as described above.
Exclusion Criteria:
- Chronically ill children like diagnosed diabetic and asthma
- Severely under nourished children (defined as body mass index z-score <-3 standard deviations of the median WHO reference population)
- Those who are treated for tuberculosis or suspected to have tuberculosis
- Children with diagnosed haemoglobinopathy (sickle cell and thalassemias)
- Children with night blindness
Sites / Locations
- Arba Minch University
Arms of the Study
Arm 1
Arm 2
Arm 3
Arm 4
Placebo Comparator
Experimental
Experimental
Experimental
Control Iron&Vitamin A Placebo
Vitamin A & Placebo Iron Supplements
Intermittent Iron Supplements & Placebo Vitamin A
Intermittent Iron Supplements & High dose Vitamin A
Children randomly assigned to the placebo iron & vitamin A control group will receive weekly three placebo tablets that are identical to the iron tablets (blinded) for the whole duration of the study (9 months of the school year). They will also receive placebo vitamin A at baseline and at mid-line (after 4.5 months).
Children is this group will receive weekly three placebo tablets that are identical to the iron tablets (blinded) for the whole duration of the study (9 months of the school year). They will also receive a high dose vitamin A capsule (200,000IU) at baseline and after 4.5 months (at mid-line)
Children is this group will receive weekly three tablets of iron (42mg of elemental iron once a week) for 9 months (equivalent to a one school year). They will also receive placebo vitamin A at baseline and at mid-line (after 4.5 months).
Combined weekly iron supplementation (42mg of elemental iron once a week) for 9 months and high dose vitamin A (200,000IU) at baseline and after 4.5 months (mid-line).