The Effect of High vs. Moderate Protein Consumption on Human Health (BEEF)
Weight Loss, Metabolism and Nutrition Disorder, Obesity
About this trial
This is an interventional treatment trial for Weight Loss focused on measuring Body composition, Metabolism
Eligibility Criteria
Inclusion Criteria:
- Healthy men or women
- Age, 18-65 years
- Overweight or grade I-II obesity (BMI 28-40.0 kg/m2)
- Provided voluntary written informed consent
Exclusion Criteria (main:
- Weight changes ± 5% in the last three months
- Vegetarian, vegan
- Pregnancy or lactation, pregnancy within the past 12 month or plans to become pregnant during the study
- History or diagnosis of diabetes
- History or diagnosis of heart, liver or kidney disease
- History or diagnosis of eating disorders
- Chronic diseases e.g. cancer within the past 5 years (except adequately-treated localized basal cell skin cancer)
- Simultaneous blood donation for other purpose than this study
- Simultaneous participation in other clinical intervention studies
- Use of drugs, that in the opinion of the medically responsible investigator, are likely to affect the outcomes of the study
- Any other condition that judged by the investigator may interfere with the adherence to the study protocol
Sites / Locations
- University of Copenhagen
Arms of the Study
Arm 1
Arm 2
Arm 3
Arm 4
Active Comparator
Experimental
Active Comparator
Experimental
VLCD-Control
VLCD-Active
Maintenance-Control
Maintenance-Active
Very low calorie diet, 600 kcal pr day for eight weeks.
Very low calorie diet plus additional 25 g protein powder, 700 kcal pr day for eight weeks.
12-week weight maintenance diets: Moderate protein weight maintenance diet (MP-WMD): Recommended healthy diet including 25 g beef daily. The diet is ad libitum and will be high in fibre (40 g/10 MJ) and whole grain (150 g/day) and allow inclusion of free/added sugar up to the recommended level (<10E% sugar).
12-week weight maintenance diets: High protein weight maintenance diet (HP-WMD): The macronutrient distribution will be 25 energy percentage (E%) from protein, 45 E% from carbohydrate and 30 E% from fat. The diet will include 150 g beef as a daily source of protein, The diet is ad libitum and will be high in fibre (40 g/10 MJ) and whole grain (150 g/day) and allow inclusion of free/added sugar up to the recommended level (<10E% sugar).