Role of Zonisamide in Advanced Parkinson's Disease (PD) in Egyptian Population: Pilot Study
Parkinson Disease
About this trial
This is an interventional treatment trial for Parkinson Disease focused on measuring Parkinson's disease, zonisamide, motor, fluctuation
Eligibility Criteria
Inclusion Criteria:
1 -Age older than 18 years of both male and female genders. 2-Individuals diagnosed with PD based on the presence of 2 of 3 cardinal features & UK bank criteria for idiopathic Parkinson's disease. 3-Patients with motor complications of PD (Hoehn and Yahr stage 2-3)(on therapy) and at least 2 hours off time.
Exclusion Criteria:
1 -Patients with atypical or secondary Parkinsonism syndromes excluding PD. 2-Patients who could not perform the tests. 3-Women who were or might be pregnant, who did not practice effective contraception and were of childbearing potential, or who were breastfeeding.
Sites / Locations
- Department of Neurology, Ain Shams University Hospital
- Ain Shams Univeristy
Arms of the Study
Arm 1
Arm 2
Arm 3
Active Comparator
Active Comparator
Placebo Comparator
Patients 25 ZNS
Patients 50 ZNS
Patients Placebo
30 patients receive oral 25 mg ZNS daily
30 patients receive oral 50 mg ZNS daily
30 patients receive placebo