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CHIEF PD (CHolinesterase Inhibitor to prEvent Falls in Parkinson's Disease) (CHIEF PD)

Primary Purpose

Parkinson Disease

Status
Recruiting
Phase
Phase 3
Locations
United Kingdom
Study Type
Interventional
Intervention
Rivastigmine Transdermal System
Placebo Transdermal System
Sponsored by
University of Bristol
About
Eligibility
Locations
Arms
Outcomes
Full info

About this trial

This is an interventional prevention trial for Parkinson Disease focused on measuring Parkinson Disease, Parkinson, Rivastigmine, Falls, Cholinesterase Inhibitors, Phase III

Eligibility Criteria

18 Years - undefined (Adult, Older Adult)All SexesDoes not accept healthy volunteers

Inclusion Criteria:

  • Diagnosis of idiopathic Parkinson's disease.
  • Modified Hoehn and Yahr stage 1-4 disease as determined at baseline visit.
  • Have experienced a fall in the previous year.
  • Able to walk ≥10m without aids or assistance.
  • 18+ years of age.

Exclusion Criteria:

  • Previous ChEi use in 12 months prior to enrolment.
  • Hypersensitivity to rivastigmine
  • Dementia diagnosed according to MDS criteria (6).
  • Inability to attend or comply with treatment or follow-up scheduling.
  • Non-English-speaking patients (cognitive tests performed in English).
  • Falling ≥4x per day.
  • Unwillingness to use an acceptable method of contraception for the duration of the trial if they are of childbearing potential.
  • Pregnancy and/or breastfeeding

Sites / Locations

  • Barking, Havering and Redbridge University Hospitals NHS trustRecruiting
  • Manchester University NHS Foundation TrustRecruiting
  • Betsi Cadwaladr University Health BoardRecruiting
  • Norfolk and Norwich University HospitalRecruiting
  • Lothian Health Board NHSRecruiting
  • NHS Forth ValleyRecruiting
  • Royal United Hospitals Bath NHS Foundation TrustRecruiting
  • NHS GrampianRecruiting
  • Barnsley Hospital NHS Foundation TrustRecruiting
  • University Hospitals Dorset NHS Foundation TrustRecruiting
  • Princess of Wales Hospital (Cwm Taf Morgannwg University Health Board)Recruiting
  • University Hospitals Bristol and Weston NHS Foundation TrustRecruiting
  • North Bristol NHS TrustRecruiting
  • Pennine Acute Hospitals NHS TrustRecruiting
  • University Hospitals of Derby and Burton NHS Foundation TrustRecruiting
  • NHS TaysideRecruiting
  • Gateshead Health NHS Foundation TrustRecruiting
  • Gloucestershire Hospitals NHS Foundation TrustRecruiting
  • Leeds Teaching Hospitals NHS TrustRecruiting
  • University Hospitals of Leicester NHS Foundation TrustRecruiting
  • The Walton Centre NHS Foundation TrustRecruiting
  • Homerton University Hospital NHS Foundation Trust
  • Imperial College Healthcare NHS TrustRecruiting
  • University College London Hospitals NHS Foundation TrustRecruiting
  • South Tees Hospitals NHS Foundation TrustRecruiting
  • Northumbria Healthcare NHS Foundation TrustRecruiting
  • Newcastle Hospitals NHS Foundation TrustRecruiting
  • Aneurin Bevan University Health BoardRecruiting
  • Oxford University HospitalsRecruiting
  • North West Anglia NHS Foundation TrustRecruiting
  • University Hospitals Plymouth NHS TrustRecruiting
  • Lancashire Teaching Hospitals NHS Foundation TrustRecruiting
  • Royal Berkshire NHS Foundation TrustRecruiting
  • Salford Royal NHS Foundation TrustRecruiting
  • North Tees and Hartlepool Hospitals NHS Foundation TrustRecruiting
  • Somerset NHS Foundation TrustRecruiting
  • Wrightington, Wigan and Leigh Teaching Hospitals NHS Foundation TrustRecruiting
  • Betsi Cadwaladr University Health BoardRecruiting
  • Yeovil District HospitalRecruiting

Arms of the Study

Arm 1

Arm 2

Arm Type

Active Comparator

Placebo Comparator

Arm Label

Active (Rivastigmine)

Placebo

Arm Description

Rivastigmine Transdermal Patches

Placebo Matched Transdermal Patches

Outcomes

Primary Outcome Measures

Fall rate
Fall rate measured using monthly diaries and telephone calls prospectively

Secondary Outcome Measures

Parkinson's Disease (PD)
MDS-UPDRS total score in the practically defined 'ON' state and each individual subscale (1-4)
Freezing of gait
New Freezing of Gait Questionnaire (NFOGQ)
Frailty
Frailty assessed by the SHARE-FI
Physical performance
Measured by the Short physical performance battery (SPPB)
Freezing of Gait Assessment
Gait speed measured with Freezing of Gait (turn test)
Gait Assessment
Gait speed measured with and without dual task
Cognition
Montreal Cognitive Assessment (MoCA)
Depression
Geriatric Depression Scale (GDS)
Fear of falling
Iconographical Fall Efficacy Scale (ICON-FES)
Dysphagia
Swallowing Disturbance Questionnaire (SDQ)
Participant health related quality of life
EuroQoL 5D-5L health status questionnaire (EQ-5D-5L)
Capability of older people
ICEpop CAPability measure for Older people (ICECAP-O)
Mortality (all cause and PD-related)
Office of National Statistics (ONS) data
Cost effectiveness by NHS resource use
NHS Hospital Episode Statistics (HES) data
Apathy
Starkstein Apathy Scale

Full Information

First Posted
December 5, 2019
Last Updated
January 17, 2023
Sponsor
University of Bristol
Collaborators
Royal United Hospitals Bath NHS Foundation Trust
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1. Study Identification

Unique Protocol Identification Number
NCT04226248
Brief Title
CHIEF PD (CHolinesterase Inhibitor to prEvent Falls in Parkinson's Disease)
Acronym
CHIEF PD
Official Title
CHolinesterase Inhibitor to prEvent Falls in Parkinson's Disease: A Phase 3 Randomised, Double-blind Placebo-controlled Trial of Rivastigmine to Prevent Falls in Parkinson's Disease.
Study Type
Interventional

2. Study Status

Record Verification Date
January 2023
Overall Recruitment Status
Recruiting
Study Start Date
January 2, 2020 (Actual)
Primary Completion Date
August 30, 2023 (Anticipated)
Study Completion Date
November 30, 2023 (Anticipated)

3. Sponsor/Collaborators

Responsible Party, by Official Title
Sponsor
Name of the Sponsor
University of Bristol
Collaborators
Royal United Hospitals Bath NHS Foundation Trust

4. Oversight

Studies a U.S. FDA-regulated Drug Product
No
Studies a U.S. FDA-regulated Device Product
No
Data Monitoring Committee
Yes

5. Study Description

Brief Summary
Parkinson's disease is a common condition particularly affecting older people. Falls are a very frequent complication of the disease affecting 60% of people with Parkinson's every year. As the population ages, the number of people living with Parkinson's disease and the occurrence of complications will increase. The loss of the chemical dopamine in the brain causes walking in Parkinson's to become slower, unsteady and irregular. People with the condition are therefore at a very high risk of falling. To some extent, people can compensate for these changes by paying more attention to their walking. However, Parkinson's also diminishes memory and thinking ability. This decreases people's ability to pay attention to their walking, especially when doing something at the same time. Cholinesterase inhibitor (ChEis) are drugs that are currently used to treat people with memory problems in Parkinson's. The effect of these drugs on falls in Parkinson's has been tested to show that treatment has the potential to almost halve the number of falls. This trial aims to definitively determine whether cholinesterase inhibitors (ChEi), can prevent falls in Parkinson's and whether this treatment is cost effective. 600 participants with Parkinson's disease will be enrolled from hospitals throughout the UK. Participants will be randomly assigned to either receive the drug (ChEi) via a patch or receive a placebo (dummy) treatment via a patch. Neither the researchers nor the participants will know which group they are in. Participants will take the medication for 12 months and record any falls that they experience in diaries. If successful, this treatment in Parkinson's disease, would tackle one of the most disabling complications of the disease and positive findings will provide robust evidence to change clinical practice.

6. Conditions and Keywords

Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
Parkinson Disease
Keywords
Parkinson Disease, Parkinson, Rivastigmine, Falls, Cholinesterase Inhibitors, Phase III

7. Study Design

Primary Purpose
Prevention
Study Phase
Phase 3
Interventional Study Model
Parallel Assignment
Model Description
A Phase III Randomised Controlled Trial of Rivastigmine versus Placebo
Masking
ParticipantCare ProviderInvestigatorOutcomes Assessor
Masking Description
Double blind
Allocation
Randomized
Enrollment
600 (Anticipated)

8. Arms, Groups, and Interventions

Arm Title
Active (Rivastigmine)
Arm Type
Active Comparator
Arm Description
Rivastigmine Transdermal Patches
Arm Title
Placebo
Arm Type
Placebo Comparator
Arm Description
Placebo Matched Transdermal Patches
Intervention Type
Drug
Intervention Name(s)
Rivastigmine Transdermal System
Intervention Description
Rivastigmine Trandermal Patches applied once a day for up to 12 months
Intervention Type
Other
Intervention Name(s)
Placebo Transdermal System
Intervention Description
Placebo Trandermal Patches applied once a day for up to 12 months
Primary Outcome Measure Information:
Title
Fall rate
Description
Fall rate measured using monthly diaries and telephone calls prospectively
Time Frame
12 months from the day the IMP is commenced
Secondary Outcome Measure Information:
Title
Parkinson's Disease (PD)
Description
MDS-UPDRS total score in the practically defined 'ON' state and each individual subscale (1-4)
Time Frame
12 months
Title
Freezing of gait
Description
New Freezing of Gait Questionnaire (NFOGQ)
Time Frame
12 months
Title
Frailty
Description
Frailty assessed by the SHARE-FI
Time Frame
12 months
Title
Physical performance
Description
Measured by the Short physical performance battery (SPPB)
Time Frame
12 months
Title
Freezing of Gait Assessment
Description
Gait speed measured with Freezing of Gait (turn test)
Time Frame
12 months
Title
Gait Assessment
Description
Gait speed measured with and without dual task
Time Frame
12 months
Title
Cognition
Description
Montreal Cognitive Assessment (MoCA)
Time Frame
12 months
Title
Depression
Description
Geriatric Depression Scale (GDS)
Time Frame
12 months
Title
Fear of falling
Description
Iconographical Fall Efficacy Scale (ICON-FES)
Time Frame
12 months
Title
Dysphagia
Description
Swallowing Disturbance Questionnaire (SDQ)
Time Frame
12 months
Title
Participant health related quality of life
Description
EuroQoL 5D-5L health status questionnaire (EQ-5D-5L)
Time Frame
0,1,3,6 9 and 12 months
Title
Capability of older people
Description
ICEpop CAPability measure for Older people (ICECAP-O)
Time Frame
12 months
Title
Mortality (all cause and PD-related)
Description
Office of National Statistics (ONS) data
Time Frame
12 months
Title
Cost effectiveness by NHS resource use
Description
NHS Hospital Episode Statistics (HES) data
Time Frame
12 months
Title
Apathy
Description
Starkstein Apathy Scale
Time Frame
12 months

10. Eligibility

Sex
All
Minimum Age & Unit of Time
18 Years
Accepts Healthy Volunteers
No
Eligibility Criteria
Inclusion Criteria: Diagnosis of idiopathic Parkinson's disease. Modified Hoehn and Yahr stage 1-4 disease as determined at baseline visit. Have experienced a fall in the previous year. Able to walk ≥10m without aids or assistance. 18+ years of age. Exclusion Criteria: Previous ChEi use in 12 months prior to enrolment. Hypersensitivity to rivastigmine Dementia diagnosed according to MDS criteria (6). Inability to attend or comply with treatment or follow-up scheduling. Non-English-speaking patients (cognitive tests performed in English). Falling ≥4x per day. Unwillingness to use an acceptable method of contraception for the duration of the trial if they are of childbearing potential. Pregnancy and/or breastfeeding
Central Contact Person:
First Name & Middle Initial & Last Name or Official Title & Degree
Sandra Neumann, PhD
Phone
04401174283111
Ext
83111
Email
chief-pd@bristol.ac.uk
First Name & Middle Initial & Last Name or Official Title & Degree
Danielle Pendry-Brazier
Phone
004401172483113
Ext
83113
Email
chief-pd@bristol.ac.uk
Overall Study Officials:
First Name & Middle Initial & Last Name & Degree
Emily Henderson, PhD
Organizational Affiliation
University of Bristol
Official's Role
Principal Investigator
Facility Information:
Facility Name
Barking, Havering and Redbridge University Hospitals NHS trust
City
Romford
State/Province
Accepted
ZIP/Postal Code
BS8 1NU
Country
United Kingdom
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Lyn Liddiard
Phone
01174283113
Email
chief-pd@bristol.ac.uk
First Name & Middle Initial & Last Name & Degree
Anjum Misbadhuddin
Facility Name
Manchester University NHS Foundation Trust
City
Manchester
State/Province
England
ZIP/Postal Code
M13 9WL
Country
United Kingdom
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Sandra Bothwell
Email
sandra.bothwell@mft.nhs.uk
First Name & Middle Initial & Last Name & Degree
Ailish Fountain
Email
ailish.fountain@mft.nhs.uk
First Name & Middle Initial & Last Name & Degree
David Ahearn, MBChB
Facility Name
Betsi Cadwaladr University Health Board
City
Bangor
State/Province
Gwynedd
ZIP/Postal Code
LL57 2PW
Country
United Kingdom
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Julia Roberts
Phone
01248 384423
Email
chief-pd@bristol.ac.uk
First Name & Middle Initial & Last Name & Degree
Sam Abraham
Facility Name
Norfolk and Norwich University Hospital
City
Norwich
State/Province
Norfolk
ZIP/Postal Code
NR4 7UY
Country
United Kingdom
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Alagaratnam Niruban
Phone
01603 288177
Email
chief-pd@bristol.ac.uk
First Name & Middle Initial & Last Name & Degree
Alagaratnam Niruban
Facility Name
Lothian Health Board NHS
City
Edinburgh
State/Province
Scotland
ZIP/Postal Code
EH1 3EG
Country
United Kingdom
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Maria Dewar
Email
maria.dewar@nhslothian.scot.nhs.uk
First Name & Middle Initial & Last Name & Degree
Katie Power
Email
katie.power@nhslothian.scot.nhs.uk
First Name & Middle Initial & Last Name & Degree
Gordon Duncan, MBChB
Facility Name
NHS Forth Valley
City
Larbert
State/Province
Scotland
ZIP/Postal Code
FK5 4WR
Country
United Kingdom
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
David Thomson
Email
david.thomson@nhs.scot
First Name & Middle Initial & Last Name & Degree
Catherine Pennington
Email
catherine.pennington@nhs.scot
First Name & Middle Initial & Last Name & Degree
Catherine Pennington, MBChB
Facility Name
Royal United Hospitals Bath NHS Foundation Trust
City
Bath
State/Province
Somerset
ZIP/Postal Code
BA1 3NG
Country
United Kingdom
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Ruth Hamlin
Phone
01225 825797
Email
chief-pd@bristol.ac.uk
First Name & Middle Initial & Last Name & Degree
Veronica Lyell
Facility Name
NHS Grampian
City
Aberdeen
ZIP/Postal Code
AB15 6RE
Country
United Kingdom
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Julie Scott
Phone
01224 557948
Email
chief-pd@bristol.ac.uk
First Name & Middle Initial & Last Name & Degree
Angus Macleod
Facility Name
Barnsley Hospital NHS Foundation Trust
City
Barnsley
ZIP/Postal Code
S75 2EP
Country
United Kingdom
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Amy Sanderson
Phone
01226 435084
Email
chief-pd@bristol.ac.uk
First Name & Middle Initial & Last Name & Degree
Bahaa Madi
Facility Name
University Hospitals Dorset NHS Foundation Trust
City
Bournemouth
ZIP/Postal Code
BH23 2JX
Country
United Kingdom
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Rochelle Hernandez
Phone
0300 019 5136
Email
chief-pd@bristol.ac.uk
First Name & Middle Initial & Last Name & Degree
Emma Gunter
Phone
0300 019 5284
First Name & Middle Initial & Last Name & Degree
Divya Tiwali
Facility Name
Princess of Wales Hospital (Cwm Taf Morgannwg University Health Board)
City
Bridgend
ZIP/Postal Code
CF31 1RQ
Country
United Kingdom
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Deborah Jones
Phone
01656 752477
Email
chief-pd@bristol.ac.uk
First Name & Middle Initial & Last Name & Degree
Sandip Raha
Facility Name
University Hospitals Bristol and Weston NHS Foundation Trust
City
Bristol
ZIP/Postal Code
BS1 3NU
Country
United Kingdom
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Emma Stratton
Phone
01174283113
Email
chief-pd@bristol.ac.uk
First Name & Middle Initial & Last Name & Degree
Emma Stratton
Facility Name
North Bristol NHS Trust
City
Bristol
ZIP/Postal Code
BS10 5NB
Country
United Kingdom
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Catherine Watkins
Phone
0117 4148276
Email
chief-pd@bristol.ac.uk
First Name & Middle Initial & Last Name & Degree
Edward Richfield
First Name & Middle Initial & Last Name & Degree
Alan Whone
Facility Name
Pennine Acute Hospitals NHS Trust
City
Bury
ZIP/Postal Code
BL9 7TD
Country
United Kingdom
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Rosan Joseph
Phone
0161 778 2634
Email
chief-pd@bristol.ac.uk
First Name & Middle Initial & Last Name & Degree
Sanniah Hussain
Phone
0161 778 2559
Email
chief-pd@bristol.ac.uk
First Name & Middle Initial & Last Name & Degree
Jason Raw
Facility Name
University Hospitals of Derby and Burton NHS Foundation Trust
City
Derby
ZIP/Postal Code
DE22 3NE
Country
United Kingdom
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Melanie Hayman
Phone
07387248757
Email
chief-pd@bristol.ac.uk
First Name & Middle Initial & Last Name & Degree
Rob Skelly
Facility Name
NHS Tayside
City
Dundee
ZIP/Postal Code
DD2 1UB
Country
United Kingdom
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Justine Hudson
First Name & Middle Initial & Last Name & Degree
Esther Sammler
Facility Name
Gateshead Health NHS Foundation Trust
City
Gateshead
ZIP/Postal Code
NE9 6SX
Country
United Kingdom
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Bryony Storey
Phone
01914456317
Email
chief-pd@bristol.ac.uk
First Name & Middle Initial & Last Name & Degree
Claire McDonald
Facility Name
Gloucestershire Hospitals NHS Foundation Trust
City
Gloucester
ZIP/Postal Code
GL1 3NN
Country
United Kingdom
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Susan Bullock
Phone
0300 4225478
Email
chief-pd@bristol.ac.uk
First Name & Middle Initial & Last Name & Degree
Sangeeta Kulkarni
Facility Name
Leeds Teaching Hospitals NHS Trust
City
Leeds
ZIP/Postal Code
LS2 3AX
Country
United Kingdom
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Prisca Mpofu
Phone
01133925073
Email
chief-pd@bristol.ac.uk
First Name & Middle Initial & Last Name & Degree
Stephen Butterworth
First Name & Middle Initial & Last Name & Degree
Jeremy Cosgrove
Facility Name
University Hospitals of Leicester NHS Foundation Trust
City
Leicester
ZIP/Postal Code
LE1 5WW
Country
United Kingdom
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Jessica Hailstone
Phone
01162586772
Email
chief-pd@bristol.ac.uk
First Name & Middle Initial & Last Name & Degree
Kate O'Kelly
Facility Name
The Walton Centre NHS Foundation Trust
City
Liverpool
ZIP/Postal Code
L9 7LJ
Country
United Kingdom
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Sarah Illingworth
Phone
0151 556 3963
Email
chief-pd@bristol.ac.uk
First Name & Middle Initial & Last Name & Degree
Michael Bonello
Facility Name
Homerton University Hospital NHS Foundation Trust
City
London
ZIP/Postal Code
E9 6SR
Country
United Kingdom
Individual Site Status
Withdrawn
Facility Name
Imperial College Healthcare NHS Trust
City
London
ZIP/Postal Code
W6 8RF
Country
United Kingdom
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Raquel Lopes
Phone
02033111714
Email
chief-pd@bristol.ac.uk
First Name & Middle Initial & Last Name & Degree
Sophie Molloy
Facility Name
University College London Hospitals NHS Foundation Trust
City
London
ZIP/Postal Code
WC1N 3BG
Country
United Kingdom
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Angelina Manoharan
Phone
2034488608
Email
chief-pd@bristol.ac.uk
First Name & Middle Initial & Last Name & Degree
Tabish Saifee
Facility Name
South Tees Hospitals NHS Foundation Trust
City
Middlesbrough
ZIP/Postal Code
TS4 3BS
Country
United Kingdom
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Marie Branch
Phone
01642854192
Email
chief-pd@bristol.ac.uk
First Name & Middle Initial & Last Name & Degree
Louise Wiblin
Facility Name
Northumbria Healthcare NHS Foundation Trust
City
Newcastle
ZIP/Postal Code
NE27 0QJ
Country
United Kingdom
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Christina Tanney
Phone
0191 2934087
Email
chief-pd@bristol.ac.uk
First Name & Middle Initial & Last Name & Degree
James Fisher
First Name & Middle Initial & Last Name & Degree
Richard Walker
Facility Name
Newcastle Hospitals NHS Foundation Trust
City
Newcastle
ZIP/Postal Code
NE7 7DN
Country
United Kingdom
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Kathryn Walker
Phone
0191 2081250
Email
chief-pd@bristol.ac.uk
First Name & Middle Initial & Last Name & Degree
Alison Yarnall
Facility Name
Aneurin Bevan University Health Board
City
Newport
ZIP/Postal Code
NP18 3XQ
Country
United Kingdom
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Sean Cutler
Phone
01633 238480
Email
chief-pd@bristol.ac.uk
First Name & Middle Initial & Last Name & Degree
Alistair Church
Facility Name
Oxford University Hospitals
City
Oxford
ZIP/Postal Code
OX3 9DU
Country
United Kingdom
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Lauren Whitestone
Phone
01865 234309
Email
chief-pd@bristol.ac.uk
First Name & Middle Initial & Last Name & Degree
Sanja Thompson
Facility Name
North West Anglia NHS Foundation Trust
City
Peterborough
ZIP/Postal Code
PE3 9GZ
Country
United Kingdom
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Natalie Temple
Phone
01733 673828
Email
chief-pd@bristol.ac.uk
First Name & Middle Initial & Last Name & Degree
Henry ALDORADIN CABEZA
Facility Name
University Hospitals Plymouth NHS Trust
City
Plymouth
ZIP/Postal Code
PL6 5FP
Country
United Kingdom
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Marina Dobranszky-oroian
Phone
01752 437 485
Email
chief-pd@bristol.ac.uk
First Name & Middle Initial & Last Name & Degree
Camille Carroll
Facility Name
Lancashire Teaching Hospitals NHS Foundation Trust
City
Preston
ZIP/Postal Code
PR2 9HT
Country
United Kingdom
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Sonia Raj
Phone
01772 522031
Email
chief-pd@bristol.ac.uk
First Name & Middle Initial & Last Name & Degree
Hedley Emsley
Facility Name
Royal Berkshire NHS Foundation Trust
City
Reading
ZIP/Postal Code
RG1 5AN
Country
United Kingdom
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Sarosh Khymani
Phone
1183226608
Email
chief-pd@bristol.ac.uk
First Name & Middle Initial & Last Name & Degree
Apurba Chatterjee
Facility Name
Salford Royal NHS Foundation Trust
City
Salford
ZIP/Postal Code
MA6 8HD
Country
United Kingdom
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Jessica Whiston
Phone
01612060534
Email
chief-pd@bristol.ac.uk
First Name & Middle Initial & Last Name & Degree
Christopher Kobylecki
Facility Name
North Tees and Hartlepool Hospitals NHS Foundation Trust
City
Stockton-on-Tees
ZIP/Postal Code
TS19 8PE
Country
United Kingdom
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Elaine Siddle
Phone
01642 624529
Email
chief-pd@bristol.ac.uk
First Name & Middle Initial & Last Name & Degree
Arunkumar Annamalai
Facility Name
Somerset NHS Foundation Trust
City
Taunton
ZIP/Postal Code
TA1 5DA
Country
United Kingdom
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Alison Whitcher
Phone
01823 343635
Email
chief-pd@bristol.ac.uk
First Name & Middle Initial & Last Name & Degree
Anita Goff
First Name & Middle Initial & Last Name & Degree
Sarah Campbell
Facility Name
Wrightington, Wigan and Leigh Teaching Hospitals NHS Foundation Trust
City
Wigan
ZIP/Postal Code
WN1 2NN
Country
United Kingdom
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Sarah Liderth
Phone
01942 822014
Email
chief-pd@bristol.ac.uk
First Name & Middle Initial & Last Name & Degree
Steve Adejumo
Facility Name
Betsi Cadwaladr University Health Board
City
Wrexham
ZIP/Postal Code
LL13 7YP
Country
United Kingdom
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Claire Watkins
Phone
03000 858033
Email
chief-pd@bristol.ac.uk
First Name & Middle Initial & Last Name & Degree
Sally Jones
Facility Name
Yeovil District Hospital
City
Yeovil
Country
United Kingdom
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Alison Lewis
Phone
01935384854
Email
chief-pd@bristol.ac.uk
First Name & Middle Initial & Last Name & Degree
Rani Sophia

12. IPD Sharing Statement

Citations:
PubMed Identifier
34715821
Citation
Neumann S, Taylor J, Bamford A, Metcalfe C, Gaunt DM, Whone A, Steeds D, Emmett SR, Hollingworth W, Ben-Shlomo Y, Henderson EJ. Cholinesterase inhibitor to prevent falls in Parkinson's disease (CHIEF-PD) trial: a phase 3 randomised, double-blind placebo-controlled trial of rivastigmine to prevent falls in Parkinson's disease. BMC Neurol. 2021 Oct 29;21(1):422. doi: 10.1186/s12883-021-02430-2.
Results Reference
derived

Learn more about this trial

CHIEF PD (CHolinesterase Inhibitor to prEvent Falls in Parkinson's Disease)

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