The Impact of Bariatric Surgery on Adipocyte Metabolism
Metabolic Syndrome, Obesity
About this trial
This is an interventional basic science trial for Metabolic Syndrome focused on measuring insulin, adipocyte, gene expression
Eligibility Criteria
Obese Subjects
Inclusion Criteria:
- 18-55 years old
- Female
- BMI greater than 40 kg/m2
- Scheduled for bariatric surgery at the Center for the Surgical Treatment of Obesity at the University of Chicago
- Signed informed consent
Exclusion Criteria:
- Male
- Diagnosed with a systemic illnesses, including heart, renal, liver, or malignant disease
- Uncontrolled hypertension (blood pressure greater than 140 mmHg systolic and 90 mmHg diastolic without medication)
- use of beta blockers
- hemoglobin less than 11.5g/dL
- known allergy to lidocaine
- pregnancy
- lactation
- Subjects will not have undergone surgery, donated a unit of blood, or participated in another clinical study within the last 4 weeks prior to consent.
- Post-menopausal
Non-Obese Subjects
Inclusion Criteria:
- 18-55 years old
- Female
- BMI less than 30 kg/m2
- Signed informed consent
Exclusion Criteria:
- Male
- Diagnosed with a systemic illnesses, including heart, renal, liver, or malignant disease
- Uncontrolled hypertension (blood pressure greater than 140 mmHg systolic and 90 mmHg diastolic without medication)
- use of beta blockers
- hemoglobin less than 11.5g/dL
- known allergy to lidocaine
- pregnancy
- lactation
- Subjects will not have undergone surgery, donated a unit of blood, or participated in another clinical study within the last 4 weeks prior to consent.
- Post-menopausal
Sites / Locations
- University of ChicagoRecruiting
Arms of the Study
Arm 1
Arm 2
Arm 3
Experimental
Active Comparator
Active Comparator
Circadian Clock Alignment - High BMI
Circadian Clock Control - High BMI
Circadian Clock Control - Low BMI
Subjects will come to the Sleep Lab three nights before their bariatric surgery procedure for an intervention that will align their central circadian clock. The intervention includes eating meals and snacks at fixed times and having lights off at a specific time at night and lights on at a specific time in the morning.
Subjects will not come to the Sleep Lab and will live normally at home with no changes to their meal, sleep or wake times.
Subjects will not come to the Sleep Lab and will live normally at home with no changes to their meal, sleep or wake times.