search
Back to results

Azento IIS 3 Year Outcomes Implant Study

Primary Purpose

Tooth Loss

Status
Enrolling by invitation
Phase
Not Applicable
Locations
United States
Study Type
Interventional
Intervention
Atlantis Abutment
Intra-oral photographs
provisional crown (te + 12 weeks)
medical history
dental history
suture removal
intra-oral digital scan
wound healing index
pain
level of satisfaction
debridement
oral hygiene
Shade selection
photographs
plaque removal
probing depth
Bleeding on probing
recession
keratinized mucosa height
plaque index
gingival index
provisional crown (te + 24 weeks)
provisional crown (te + 36 weeks)
Sponsored by
Christopher Barwacz
About
Eligibility
Locations
Arms
Outcomes
Full info

About this trial

This is an interventional treatment trial for Tooth Loss focused on measuring alveolar bone, alveolar ridge, bone grafting, bone resorption, dental implant

Eligibility Criteria

18 Years - undefined (Adult, Older Adult)All SexesAccepts Healthy Volunteers

Inclusion Criteria: patients participating in University of Iowa IRB approved study 201806050 or

  • Subjects may identify as either male, female, or intersex
  • Age: 18 years or older
  • Subjects with a healed, single-rooted tooth (except mandibular incisors) that has previously undergone ARP-SG with anorganic bovine bone mineral graft
  • Subjects must have stable occlusion, with absence of caries or other known acute pathology (i.e., untreated endodontic lesion, periodontal abscess, external/internal resorption, etc.) on teeth proximal to the implant site that would negatively influence implant outcomes
  • Must be in adequate physical and mental health to undergo routine dental treatment including the surgical procedures associated tooth extraction and implant placement
  • Subjects' treatment plan must include replacement of the tooth to be extracted with dental implant supported fixed restoration
  • Subjects must have read, understood and signed an informed consent form
  • Subjects must be willing to return for the required number of visits

Exclusion Criteria:

  • - Acute infection associated with the tooth to be extracted or with adjacent teeth
  • Unstable occlusion, presence of caries or other acute pathology on teeth adjacent to the implant site
  • History of significant heart, stomach, liver, kidney, blood, immune system disease, or other organ impairment or systemic diseases that would prevent undergoing the proposed treatment or may result in compromised healing (e.g. poorly controlled diabetes, active heavy tobacco use [>10 cigs/day])
  • Subjects with uncontrolled and/or severe metabolic bone diseases or disorders, such as osteoporosis, thyroid disorders or Paget's disease
  • Subjects taking any medication or supplement known to largely influence bone metabolism, such as IV bisphosphonates, long-term history of oral bisphosphonates or chronic intake of glucocorticoids
  • Pregnant women or nursing mothers
  • Subjects that are unwilling or unable to sign the informed consent
  • History of lack of compliance with dental visits
  • Subjects unwilling to return for the required number of visits

Sites / Locations

  • University of Iowa

Arms of the Study

Arm 1

Arm 2

Arm 3

Arm Type

Active Comparator

Active Comparator

Active Comparator

Arm Label

Group 1

Group 2

Group 3

Arm Description

Group 1: 3 months post-ARP-SG and dental implant placement using Azento® with an Astra Tech Implant® EV implant and immediate implant provisionalization using Azento®. At 3 months post-DIP&P, a definitive all-ceramic crown, fabricated using a digital workflow (CoreFile), will be placed

Group 2: at 6 months post-ARP-SG and dental implant placement using Azento® with an Astra Tech Implant® EV implant and immediate implant provisionalization using Azento®. At 3 months post-DIP&P, a definitive all-ceramic crown, fabricated using a digital workflow (CoreFile), will be placed.

Group 3: 9 months post-ARP-SG and dental implant placement using Azento® with an Astra Tech Implant® EV implant and immediate implant provisionalization using Azento®. At 3 months post-DIP&P, a definitive all-ceramic crown, fabricated using a digital workflow (CoreFile), will be placed

Outcomes

Primary Outcome Measures

Implant survival
did the implant survive

Secondary Outcome Measures

% of vital bone via histomorphotmetric evaluation of bone core biopsies at 3 months
% of vital bone
% of vital bone via histomorphotmetric evaluation of bone core biopsies at 6 months
% of vital bone
% of vital bone via histomorphotmetric evaluation of bone core biopsies at 9 months
% of vital bone
Insertion torque values
resonance frequency analysis (RFA) measured by implant stability quotient (ISQ)
Insertion torque values
resonance frequency analysis (RFA) measured by implant stability quotient (ISQ)
Insertion torque values
resonance frequency analysis (RFA) measured by implant stability quotient (ISQ)

Full Information

First Posted
January 31, 2020
Last Updated
July 6, 2023
Sponsor
Christopher Barwacz
search

1. Study Identification

Unique Protocol Identification Number
NCT04255342
Brief Title
Azento IIS 3 Year Outcomes Implant Study
Official Title
Clinical, Radiographic, and Histomorphometric Analysis of AstraTech Implant EV Placed and Immediately Provisionalized Into Preserved Alveolar Ridges: A Prospective 3-Year Outcomes Study
Study Type
Interventional

2. Study Status

Record Verification Date
July 2023
Overall Recruitment Status
Enrolling by invitation
Study Start Date
January 29, 2020 (Actual)
Primary Completion Date
December 31, 2025 (Anticipated)
Study Completion Date
December 31, 2025 (Anticipated)

3. Sponsor/Collaborators

Responsible Party, by Official Title
Sponsor-Investigator
Name of the Sponsor
Christopher Barwacz

4. Oversight

Studies a U.S. FDA-regulated Drug Product
No
Studies a U.S. FDA-regulated Device Product
Yes
Product Manufactured in and Exported from the U.S.
Yes
Data Monitoring Committee
No

5. Study Description

Brief Summary
The purpose of this research study is to compare and evaluate the implant-body stability, survival rate, bone level changes and the implant's soft-tissue outcomes over a three year follow-up around AstraTech Implant System (ATIS) Evolution (EV) implants placed and immediately temporized with an artificial prosthetic tooth in ridges that have healed following ARP-SG for different time intervals.intervals. Patients participating in this study are expected to return to the University of Iowa College of Dentistry for a total of 9 visits. The estimated study length per subject will vary between 42 to 48 months depending on group allocation.
Detailed Description
Group 1: 3 months after ARP-SG, a dental implant will be placed using Azento® with an AstraTech Implant System EV and an immediate implant temporary crown using Azento®. After 3 months with the temporary crown, a definitive all-ceramic crown, made using a digital workflow will be placed. Group 2: 6 months after ARP-SG, a dental implant will be placed using Azento® with an AstraTech Implant System EV and an immediate temporary crown using Azento®. After 3 months with the temporary crown, a definitive all-ceramic crown, made using a digital workflow will be placed. Group 3: 9 months after ARP-SG, a dental implant will be placed using Azento® with an AstraTech Implant System EV and an immediate temporary crown using Azento®. After 3 months with the temporary crown, a definitive all-ceramic crown, made using a digital workflow will be placed. SCREENING - Visit 1 After reading and signing the informed consent form, participants will complete a detailed medical and dental history form. The investigators will review the form with the participant to ensure they can safely participate in the study. Participants will also have an oral exam to determine if the participant qualifies for the study VISIT 2: Abutment & Crown Placement Group 1 (TE + 14 weeks) Group 2 (TE + 26 weeks) Group 3 (TE + 38 weeks) Intra-oral photographs of the sites of interest will be obtained. Participants may or may not have had their implant and bone core biopsy completed as part of their participation in IRB 201806050, Clinical, radiographic and histomorphotmetric analysis of healing dynamics in human extraction sockets grafted with Bio-Oss Collagen®: A prospective 3-year post-loading study or the participants routine clinical care. At the same visit when the implant is surgically installed, the investigators will then place a prosthetic abutment and temporary crown. Participants will also receive home care instructions before they leave. This visit will last about between 1.5 to 2 hours. VISIT 3, 4, 5: Postop (2, 6, 12 week follow-ups after implant placement) Participants will return to the clinic at 2, 6 and 12 weeks which is standard of care in many cases for implant follow-up and restoration. At this time the investigators will update medical and dental histories. Photographs and intra-oral scans (multiple digital photographs) will be taken. The investigators will review any xrays on file to assess bone levels around the implant. Sutures will be removed. Participants will be asked some questions regarding their pain and level of satisfaction in addition to the healing status of their wound. The sites will be debrided (cleaned) and oral hygiene instructions will be reviewed. At visit 4 the shade of their new permanent crown will be selected. These visits will last approximately 30-60 minutes. VISIT 6: Final Restoration Delivery (Implant Placement + 16 weeks) The investigators will update medical and dental histories. The abutment and crown will be examined. The temporary crown will be replaced with a permanent crown. Photographs and intra-oral scans (multiple digital photographs) will be taken. The participant will be asked some questions regarding pain and level of satisfaction in addition to the healing status of their wound. This visit will last approximately 60-90 minutes. VISIT 7, 8 & 9: Implant Follow-ups #1, 2 & 3 (1, 2 & 3 years after delivery of final restoration) The participant will return to the clinic at 1, 2 and 3 years after delivery of the final restoration which is standard of care in many cases for implant restoration. At these times the investigators will update medical and dental histories . Photographs and intra-oral scans (multiple digital photographs) will be taken. An oral exam will be completed. Plaque will be removed if necessary, and oral hygiene instructions will be reviewed. Clinical measurements will be recorded. The investigators will review any xrays on file to assess bone levels around the implant. These visits will last approximately 60 minutes. Visit 9 will be the last visit.

6. Conditions and Keywords

Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
Tooth Loss
Keywords
alveolar bone, alveolar ridge, bone grafting, bone resorption, dental implant

7. Study Design

Primary Purpose
Treatment
Study Phase
Not Applicable
Interventional Study Model
Parallel Assignment
Masking
Outcomes Assessor
Masking Description
Assessors collecting the data and conducting the appropriate statistical analyses for all outcomes in the study will be blinded
Allocation
Randomized
Enrollment
42 (Anticipated)

8. Arms, Groups, and Interventions

Arm Title
Group 1
Arm Type
Active Comparator
Arm Description
Group 1: 3 months post-ARP-SG and dental implant placement using Azento® with an Astra Tech Implant® EV implant and immediate implant provisionalization using Azento®. At 3 months post-DIP&P, a definitive all-ceramic crown, fabricated using a digital workflow (CoreFile), will be placed
Arm Title
Group 2
Arm Type
Active Comparator
Arm Description
Group 2: at 6 months post-ARP-SG and dental implant placement using Azento® with an Astra Tech Implant® EV implant and immediate implant provisionalization using Azento®. At 3 months post-DIP&P, a definitive all-ceramic crown, fabricated using a digital workflow (CoreFile), will be placed.
Arm Title
Group 3
Arm Type
Active Comparator
Arm Description
Group 3: 9 months post-ARP-SG and dental implant placement using Azento® with an Astra Tech Implant® EV implant and immediate implant provisionalization using Azento®. At 3 months post-DIP&P, a definitive all-ceramic crown, fabricated using a digital workflow (CoreFile), will be placed
Intervention Type
Device
Intervention Name(s)
Atlantis Abutment
Intervention Description
A gold-hue titanium Atlantis abutment will be connected and secured to the implant fixture, and a provisional screwmentable PMMA crown seated to verify marginal adaptation, proximal contact intensity, and occlusion. Upon any necessary modifications and adjustments to the provisional crown, the abutment and crown will be cemented extraorally, disinfected ultrasonically in 0.12% chlorohexidine gluconate, and torqued to 25N/cm2, and screw-access channel obturated with polytetrafluorethylene (PTFE) tape and resin composite.
Intervention Type
Procedure
Intervention Name(s)
Intra-oral photographs
Intervention Description
Intra-oral photographs of the sites of interest will be obtained
Intervention Type
Device
Intervention Name(s)
provisional crown (te + 12 weeks)
Intervention Description
modifications and adjustments to the provisional crown, the abutment and crown will be cemented extraorally, disinfected ultrasonically in 0.12% chlorohexidine gluconate, and torqued to 25N/cm2, and screw-access channel obturated with polytetrafluorethylene (PTFE) tape and resin composite.
Intervention Type
Other
Intervention Name(s)
medical history
Intervention Description
medical history updated to medical record
Intervention Type
Other
Intervention Name(s)
dental history
Intervention Description
dental history updated to medical record
Intervention Type
Procedure
Intervention Name(s)
suture removal
Intervention Description
sutures will be removed
Intervention Type
Procedure
Intervention Name(s)
intra-oral digital scan
Intervention Description
An intra-oral digital scan of the arch will be obtained using an intra-oral scanner
Intervention Type
Diagnostic Test
Intervention Name(s)
wound healing index
Intervention Description
Visual assessment of the healing status will be made using a wound healing index (WHI)
Intervention Type
Other
Intervention Name(s)
pain
Intervention Description
Participants will be asked to report pain in terms of function, comfort and esthetics (PROMs).
Intervention Type
Other
Intervention Name(s)
level of satisfaction
Intervention Description
Participants will be asked to report level of satisfaction in terms of function, comfort and esthetics (PROMs).
Intervention Type
Procedure
Intervention Name(s)
debridement
Intervention Description
wound will be debrided
Intervention Type
Other
Intervention Name(s)
oral hygiene
Intervention Description
oral hygiene instructions will be given
Intervention Type
Other
Intervention Name(s)
Shade selection
Intervention Description
definitive shade selection will occur at this appointment, and a final monolithic screwmentable all-ceramic zirconium-oxide crown will be fabricated from the original Atlantis CoreFile
Intervention Type
Other
Intervention Name(s)
photographs
Intervention Description
Intra-oral photographs will be obtained using a dSLR camera
Intervention Type
Procedure
Intervention Name(s)
plaque removal
Intervention Description
removal of plaque on crown and surrounding teeth
Intervention Type
Other
Intervention Name(s)
probing depth
Intervention Description
probing depths will be measured
Intervention Type
Other
Intervention Name(s)
Bleeding on probing
Intervention Description
bleeding on probing will be recorded
Intervention Type
Other
Intervention Name(s)
recession
Intervention Description
recession respective to the incisal/occlusal plane
Intervention Type
Other
Intervention Name(s)
keratinized mucosa height
Intervention Description
keratinized mucosa height
Intervention Type
Other
Intervention Name(s)
plaque index
Intervention Description
plaque index
Intervention Type
Other
Intervention Name(s)
gingival index
Intervention Description
gingival index
Intervention Type
Device
Intervention Name(s)
provisional crown (te + 24 weeks)
Intervention Description
modifications and adjustments to the provisional crown, the abutment and crown will be cemented extraorally, disinfected ultrasonically in 0.12% chlorohexidine gluconate, and torqued to 25N/cm2, and screw-access channel obturated with polytetrafluorethylene (PTFE) tape and resin composite.
Intervention Type
Device
Intervention Name(s)
provisional crown (te + 36 weeks)
Intervention Description
modifications and adjustments to the provisional crown, the abutment and crown will be cemented extraorally, disinfected ultrasonically in 0.12% chlorohexidine gluconate, and torqued to 25N/cm2, and screw-access channel obturated with polytetrafluorethylene (PTFE) tape and resin composite.
Primary Outcome Measure Information:
Title
Implant survival
Description
did the implant survive
Time Frame
3 years post implant loading
Secondary Outcome Measure Information:
Title
% of vital bone via histomorphotmetric evaluation of bone core biopsies at 3 months
Description
% of vital bone
Time Frame
3 months
Title
% of vital bone via histomorphotmetric evaluation of bone core biopsies at 6 months
Description
% of vital bone
Time Frame
6 months
Title
% of vital bone via histomorphotmetric evaluation of bone core biopsies at 9 months
Description
% of vital bone
Time Frame
9 months
Title
Insertion torque values
Description
resonance frequency analysis (RFA) measured by implant stability quotient (ISQ)
Time Frame
3 months
Title
Insertion torque values
Description
resonance frequency analysis (RFA) measured by implant stability quotient (ISQ)
Time Frame
6 months
Title
Insertion torque values
Description
resonance frequency analysis (RFA) measured by implant stability quotient (ISQ)
Time Frame
9 months

10. Eligibility

Sex
All
Minimum Age & Unit of Time
18 Years
Accepts Healthy Volunteers
Accepts Healthy Volunteers
Eligibility Criteria
Inclusion Criteria: patients participating in University of Iowa IRB approved study 201806050 or Subjects may identify as either male, female, or intersex Age: 18 years or older Subjects with a healed, single-rooted tooth (except mandibular incisors) that has previously undergone ARP-SG with anorganic bovine bone mineral graft Subjects must have stable occlusion, with absence of caries or other known acute pathology (i.e., untreated endodontic lesion, periodontal abscess, external/internal resorption, etc.) on teeth proximal to the implant site that would negatively influence implant outcomes Must be in adequate physical and mental health to undergo routine dental treatment including the surgical procedures associated tooth extraction and implant placement Subjects' treatment plan must include replacement of the tooth to be extracted with dental implant supported fixed restoration Subjects must have read, understood and signed an informed consent form Subjects must be willing to return for the required number of visits Exclusion Criteria: - Acute infection associated with the tooth to be extracted or with adjacent teeth Unstable occlusion, presence of caries or other acute pathology on teeth adjacent to the implant site History of significant heart, stomach, liver, kidney, blood, immune system disease, or other organ impairment or systemic diseases that would prevent undergoing the proposed treatment or may result in compromised healing (e.g. poorly controlled diabetes, active heavy tobacco use [>10 cigs/day]) Subjects with uncontrolled and/or severe metabolic bone diseases or disorders, such as osteoporosis, thyroid disorders or Paget's disease Subjects taking any medication or supplement known to largely influence bone metabolism, such as IV bisphosphonates, long-term history of oral bisphosphonates or chronic intake of glucocorticoids Pregnant women or nursing mothers Subjects that are unwilling or unable to sign the informed consent History of lack of compliance with dental visits Subjects unwilling to return for the required number of visits
Overall Study Officials:
First Name & Middle Initial & Last Name & Degree
Christopher Barwacz, DDS
Organizational Affiliation
University of Iowa
Official's Role
Principal Investigator
Facility Information:
Facility Name
University of Iowa
City
Iowa City
State/Province
Iowa
ZIP/Postal Code
52242
Country
United States

12. IPD Sharing Statement

Citations:
PubMed Identifier
23845297
Citation
Alkan EA, Parlar A, Yildirim B, Senguven B. Histological comparison of healing following tooth extraction with ridge preservation using enamel matrix derivatives versus Bio-Oss Collagen: a pilot study. Int J Oral Maxillofac Surg. 2013 Dec;42(12):1522-8. doi: 10.1016/j.ijom.2013.06.002. Epub 2013 Jul 8.
Results Reference
background
PubMed Identifier
18546808
Citation
Araujo M, Linder E, Wennstrom J, Lindhe J. The influence of Bio-Oss Collagen on healing of an extraction socket: an experimental study in the dog. Int J Periodontics Restorative Dent. 2008 Apr;28(2):123-35.
Results Reference
background
PubMed Identifier
24621203
Citation
Araujo MG, da Silva JCC, de Mendonca AF, Lindhe J. Ridge alterations following grafting of fresh extraction sockets in man. A randomized clinical trial. Clin Oral Implants Res. 2015 Apr;26(4):407-412. doi: 10.1111/clr.12366. Epub 2014 Mar 12.
Results Reference
background
PubMed Identifier
20070748
Citation
Araujo MG, Liljenberg B, Lindhe J. Dynamics of Bio-Oss Collagen incorporation in fresh extraction wounds: an experimental study in the dog. Clin Oral Implants Res. 2010 Jan;21(1):55-64. doi: 10.1111/j.1600-0501.2009.01854.x.
Results Reference
background
PubMed Identifier
28429394
Citation
Arora H, Khzam N, Roberts D, Bruce WL, Ivanovski S. Immediate implant placement and restoration in the anterior maxilla: Tissue dimensional changes after 2-5 year follow up. Clin Implant Dent Relat Res. 2017 Aug;19(4):694-702. doi: 10.1111/cid.12487. Epub 2017 Apr 21.
Results Reference
background
PubMed Identifier
24966231
Citation
Avila-Ortiz G, Elangovan S, Kramer KW, Blanchette D, Dawson DV. Effect of alveolar ridge preservation after tooth extraction: a systematic review and meta-analysis. J Dent Res. 2014 Oct;93(10):950-8. doi: 10.1177/0022034514541127. Epub 2014 Jun 25.
Results Reference
background
PubMed Identifier
18672985
Citation
Barone A, Aldini NN, Fini M, Giardino R, Calvo Guirado JL, Covani U. Xenograft versus extraction alone for ridge preservation after tooth removal: a clinical and histomorphometric study. J Periodontol. 2008 Aug;79(8):1370-7. doi: 10.1902/jop.2008.070628.
Results Reference
background
Citation
Barwacz, C. & Hernandez, M. (2013) Maximizing Esthetics of Fixed Interim Restorations via Direct Extrinsic Characterization. Journal of Cosmetic Dentistry 29, 122-131.
Results Reference
background
PubMed Identifier
28572416
Citation
Barwacz CA, Pantzlaff E, Allareddy V, Avila-Ortiz G. Graduate Periodontics Programs' Integration of Implant Provisionalization in Core Curricula: Implementation of CODA Standard 4-10.2.d. J Dent Educ. 2017 Jun;81(6):696-706. doi: 10.21815/JDE.016.033.
Results Reference
background
PubMed Identifier
30231101
Citation
Barwacz CA, Stanford CM, Diehl UA, Cooper LF, Feine J, McGuire M, Scheyer ET. Pink Esthetic Score Outcomes Around Three Implant-Abutment Configurations: 3-Year Results. Int J Oral Maxillofac Implants. 2018 Sep/Oct;33(5):1126-1135. doi: 10.11607/jomi.6659.
Results Reference
background
PubMed Identifier
30695089
Citation
Cooper LF, Reside G, Stanford C, Barwacz C, Feine J, Nader SA, Scheyer T, McGuire M. Three-Year Prospective Randomized Comparative Assessment of Anterior Maxillary Single Implants with Different Abutment Interfaces. Int J Oral Maxillofac Implants. 2019 Jan/Feb;34(1):150-158. doi: 10.11607/jomi.6810.
Results Reference
background
PubMed Identifier
27560668
Citation
Cooper LF, Tarnow D, Froum S, Moriarty J, De Kok IJ. Comparison of Marginal Bone Changes with Internal Conus and External Hexagon Design Implant Systems: A Prospective, Randomized Study. Int J Periodontics Restorative Dent. 2016 Sep-Oct;36(5):631-42. doi: 10.11607/prd.2433.
Results Reference
background
PubMed Identifier
29513776
Citation
Crespi R, Cappare P, Crespi G, Gastaldi G, Romanos GE, Gherlone E. Tissue Remodeling in Immediate Versus Delayed Prosthetic Restoration in Fresh Socket Implants in the Esthetic Zone: Four-Year Follow-up. Int J Periodontics Restorative Dent. 2018;38(Suppl):s97-s103. doi: 10.11607/prd.3123. Epub 2018 Mar 7.
Results Reference
background
PubMed Identifier
19302238
Citation
De Rouck T, Collys K, Wyn I, Cosyn J. Instant provisionalization of immediate single-tooth implants is essential to optimize esthetic treatment outcome. Clin Oral Implants Res. 2009 Jun;20(6):566-70. doi: 10.1111/j.1600-0501.2008.01674.x. Epub 2009 Mar 3.
Results Reference
background
PubMed Identifier
16307569
Citation
Furhauser R, Florescu D, Benesch T, Haas R, Mailath G, Watzek G. Evaluation of soft tissue around single-tooth implant crowns: the pink esthetic score. Clin Oral Implants Res. 2005 Dec;16(6):639-44. doi: 10.1111/j.1600-0501.2005.01193.x.
Results Reference
background
PubMed Identifier
19040436
Citation
Heberer S, Al-Chawaf B, Hildebrand D, Nelson JJ, Nelson K. Histomorphometric analysis of extraction sockets augmented with Bio-Oss Collagen after a 6-week healing period: a prospective study. Clin Oral Implants Res. 2008 Dec;19(12):1219-25. doi: 10.1111/j.1600-0501.2008.01617.x. No abstract available.
Results Reference
background
PubMed Identifier
22244384
Citation
Heinemann F, Hasan I, Schwahn C, Bourauel C, Mundt T. Bone level change of extraction sockets with Bio-Oss collagen and implant placement: a clinical study. Ann Anat. 2012 Nov;194(6):508-12. doi: 10.1016/j.aanat.2011.11.012. Epub 2011 Dec 23.
Results Reference
background
PubMed Identifier
12931761
Citation
Iasella JM, Greenwell H, Miller RL, Hill M, Drisko C, Bohra AA, Scheetz JP. Ridge preservation with freeze-dried bone allograft and a collagen membrane compared to extraction alone for implant site development: a clinical and histologic study in humans. J Periodontol. 2003 Jul;74(7):990-9. doi: 10.1902/jop.2003.74.7.990.
Results Reference
background
PubMed Identifier
23163915
Citation
Jung RE, Philipp A, Annen BM, Signorelli L, Thoma DS, Hammerle CH, Attin T, Schmidlin P. Radiographic evaluation of different techniques for ridge preservation after tooth extraction: a randomized controlled clinical trial. J Clin Periodontol. 2013 Jan;40(1):90-8. doi: 10.1111/jcpe.12027. Epub 2012 Nov 19.
Results Reference
background
PubMed Identifier
12608666
Citation
Kan JY, Rungcharassaeng K, Lozada J. Immediate placement and provisionalization of maxillary anterior single implants: 1-year prospective study. Int J Oral Maxillofac Implants. 2003 Jan-Feb;18(1):31-9.
Results Reference
background
PubMed Identifier
12747463
Citation
Kan JY, Rungcharassaeng K, Umezu K, Kois JC. Dimensions of peri-implant mucosa: an evaluation of maxillary anterior single implants in humans. J Periodontol. 2003 Apr;74(4):557-62. doi: 10.1902/jop.2003.74.4.557.
Results Reference
background
PubMed Identifier
9203100
Citation
Lekovic V, Kenney EB, Weinlaender M, Han T, Klokkevold P, Nedic M, Orsini M. A bone regenerative approach to alveolar ridge maintenance following tooth extraction. Report of 10 cases. J Periodontol. 1997 Jun;68(6):563-70. doi: 10.1902/jop.1997.68.6.563.
Results Reference
background
PubMed Identifier
27335267
Citation
Nart J, Barallat L, Jimenez D, Mestres J, Gomez A, Carrasco MA, Violant D, Ruiz-Magaz V. Radiographic and histological evaluation of deproteinized bovine bone mineral vs. deproteinized bovine bone mineral with 10% collagen in ridge preservation. A randomized controlled clinical trial. Clin Oral Implants Res. 2017 Jul;28(7):840-848. doi: 10.1111/clr.12889. Epub 2016 Jun 22.
Results Reference
background
PubMed Identifier
16515093
Citation
Nevins M, Camelo M, De Paoli S, Friedland B, Schenk RK, Parma-Benfenati S, Simion M, Tinti C, Wagenberg B. A study of the fate of the buccal wall of extraction sockets of teeth with prominent roots. Int J Periodontics Restorative Dent. 2006 Feb;26(1):19-29.
Results Reference
background
PubMed Identifier
26300062
Citation
Noelken R, Oberhansl F, Kunkel M, Wagner W. Immediately provisionalized OsseoSpeed() Profile implants inserted into extraction sockets: 3-year results. Clin Oral Implants Res. 2016 Jun;27(6):744-9. doi: 10.1111/clr.12651. Epub 2015 Aug 24.
Results Reference
background
PubMed Identifier
21691604
Citation
Ponsi J, Lahti S, Rissanen H, Oikarinen K. Change in subjective oral health after single dental implant treatment. Int J Oral Maxillofac Implants. 2011 May-Jun;26(3):571-7.
Results Reference
background
PubMed Identifier
21504481
Citation
Raes F, Cooper LF, Tarrida LG, Vandromme H, De Bruyn H. A case-control study assessing oral-health-related quality of life after immediately loaded single implants in healed alveolar ridges or extraction sockets. Clin Oral Implants Res. 2012 May;23(5):602-8. doi: 10.1111/j.1600-0501.2011.02178.x. Epub 2011 Apr 19.
Results Reference
background
PubMed Identifier
26800389
Citation
Roccuzzo M, Gaudioso L, Lungo M, Dalmasso P. Surgical therapy of single peri-implantitis intrabony defects, by means of deproteinized bovine bone mineral with 10% collagen. J Clin Periodontol. 2016 Mar;43(3):311-8. doi: 10.1111/jcpe.12516. Epub 2016 Mar 9.
Results Reference
background
PubMed Identifier
27617409
Citation
Scheyer ET, Heard R, Janakievski J, Mandelaris G, Nevins ML, Pickering SR, Richardson CR, Pope B, Toback G, Velasquez D, Nagursky H. A randomized, controlled, multicentre clinical trial of post-extraction alveolar ridge preservation. J Clin Periodontol. 2016 Dec;43(12):1188-1199. doi: 10.1111/jcpe.12623. Epub 2016 Oct 21.
Results Reference
background
PubMed Identifier
19961991
Citation
Spyropoulou PE, Razzoog M, Sierraalta M. Restoring implants in the esthetic zone after sculpting and capturing the periimplant tissues in rest position: a clinical report. J Prosthet Dent. 2009 Dec;102(6):345-7. doi: 10.1016/S0022-3913(09)60189-X.
Results Reference
background
PubMed Identifier
27447160
Citation
Stanford CM, Barwacz C, Raes S, De Bruyn H, Cecchinato D, Bittner N, Brandt J. Multicenter Clinical Randomized Controlled Trial Evaluation of an Implant System Designed for Enhanced Primary Stability. Int J Oral Maxillofac Implants. 2016 Jul-Aug;31(4):906-15. doi: 10.11607/jomi.4869.
Results Reference
background
PubMed Identifier
24438506
Citation
Strietzel FP, Neumann K, Hertel M. Impact of platform switching on marginal peri-implant bone-level changes. A systematic review and meta-analysis. Clin Oral Implants Res. 2015 Mar;26(3):342-58. doi: 10.1111/clr.12339. Epub 2014 Jan 20.
Results Reference
background
PubMed Identifier
20664835
Citation
Su H, Gonzalez-Martin O, Weisgold A, Lee E. Considerations of implant abutment and crown contour: critical contour and subcritical contour. Int J Periodontics Restorative Dent. 2010 Aug;30(4):335-43.
Results Reference
background

Learn more about this trial

Azento IIS 3 Year Outcomes Implant Study

We'll reach out to this number within 24 hrs