Effect of Exercise on Biomarkers in SCT
Sickle Cell Trait
About this trial
This is an interventional diagnostic trial for Sickle Cell Trait focused on measuring Sickle Cell Trait
Eligibility Criteria
Inclusion Criteria: Sickle Cell Trait Group (AS)
- Health subjects with sickle cell trait (AS)
- Ages 18-70 years
Inclusion Criteria: Control group (AA)
- Healthy subjects without sickle cell trait (AA)
- Ages 18-70 years
Exclusion Criteria: Sickle Cell Trait group (AS) AND healthy controls (AA).
Subjects will be excluded if they:
- weigh less than 110 pounds,
- are pregnant,
- have hemoglobinopathies (other than sickle cell trait) as determined by Hb electrophoresis,
- have other self-reported conditions known to cause blood coagulation activation, myocyte destruction, hemolysis, chronic inflammation, or renal disease
- any condition that places subjects at risk during exercise.
Sites / Locations
- Saint Louis UniversityRecruiting
Arms of the Study
Arm 1
Arm 2
Experimental
Active Comparator
SCT Group
Control Group
Fifteen SCT subjects will be recruited, consented, screened, and enrolled if they meet inclusion and exclusion criteria. Each subject will undergo a single bout of standardized exercise on a treadmill. Subjects will self-select treadmill speed at 0% grade and begin. After 3 minutes the grade will be increased by 1% every 2 minutes until the target heart rate (70% of heart rate reserve) is reached. Speed and grade will be held constant for 15 minutes, marking the end of the session.
Five healthy subjects will be recruited, consented, screened, and enrolled if they meet inclusion and exclusion criteria. Each subject will undergo a single bout of standardized exercise on a treadmill. Subjects will self-select treadmill speed at 0% grade and begin. After 3 minutes the grade will be increased by 1% every 2 minutes until the target heart rate (70% of heart rate reserve) is reached. Speed and grade will be held constant for 15 minutes, marking the end of the session.