L-arginine and Asymmetric Dimethylarginine (ADMA) and Lifestyle Protocols
Diabetes Mellitus, Type 2, Obesity, Arginine

About this trial
This is an interventional other trial for Diabetes Mellitus, Type 2
Eligibility Criteria
Inclusion Criteria:
- obese and/ or T2DM subjects
Exclusion Criteria:
- type 1 diabetes
- insulin-treated T2DM
- active coronary disease (recent [≤ 6months] myocardial infarction, unstable angina, recent coronary catheterization, or coronary bypass grafting
- individuals with significant impairment in liver enzymes (≥ 2.5 the upper limit of the normal range)
- serum creatinine higher than 1.5mg%
- known malabsorption, alcoholism or illicit use of drugs
- abnormal thyroid function tests
- concomitant or recent use of glucocorticoids
- uncertain mental state (to avoid invalid informed consent or lack of compliance).
Sites / Locations
- Diabetes Unit, E. Wolfson Medical Center
Arms of the Study
Arm 1
Arm 2
Arm 3
Arm 4
Arm 5
Arm 6
Experimental
Experimental
Experimental
Experimental
Experimental
Experimental
Acute glucose tolerance test
Acute protein load test
Acute fat load test
Acute alcohol load test
Acute exercise
Lifestyle modification program - 12 weeks
A standard oral glucose tolerance test (75 grams of dextrose in 180 cc of water)
A protein-rich, vanilla-flavored powder (Pro-gym, Telpharma, Is
a 100-gram portion of sweet cream containing 300 Kacls, of which 94% of the ingested calories were fat
Vodka (100 cc, 40% alcohol)
30 minutes of supervised graded walking on a treadmill according to each subject's individual ability. A goal heart rate was calculated as 70% of the age-adjusted maximal allowable heart rate.
12 weeks of weight-loss dietary program constructed according to the guidelines of the American Diabetes Association. Based on weight, gender, and age, daily dietary allowance varied at 1200-1800 Kcal, 50% carbohydrates, 20% protein, and 30% fat. Participants were also asked to engage in moderate physical activity comprised of a 40-minute walk three times a week. A weekly clinic visit alternating with a weekly telephone contact was also required.