Nutritional Intervention and Outcomes in Elderly After Hip Fracture Surgery
Elderly Patients, Malnutrition, Hip Fractures
About this trial
This is an interventional prevention trial for Elderly Patients focused on measuring Elderly patients, Malnutrition, Hip Fractures, Nutritional intervention, Perioperative outcomes, Long-term survival
Eligibility Criteria
Inclusion Criteria:
- Age ≥70 years old;
- Hospitalized for hip fracture, scheduled to undergo hip-fracture surgery within 48 hours;
- Classified as malnutrition or at risk of malnutrition according to the short form mini-nutrition assessment (MNA-SF);
- Provide written informed consents.
Exclusion Criteria:
- Pathological fracture;
- History of schizophrenia, epilepsy, Parkinson's disease, or myasthenia gravis before surgery;
- Unable to communicate due to coma, severe dementia, or language barrier;
- Unable to eat due to any disease in the gastrointestinal system;
- Severe hepatic dysfunction (Child-Pugh class C), renal failure (requirement of renal replacement therapy), respiratory failure (requirement of respiratory support), cardiac insufficiency (New York Heart Association classification ≥IV), or American Socisty of Anesthesiologists classification ≥IV;
- Preexisting organ injury before surgery (delirium, acute kidney injury, myocardial injury, etc.);
- Other conditions that are considered unsuitable for study participation.
Sites / Locations
- Peking University First HospitalRecruiting
- Fourth Medical Center of PLA General HospitalRecruiting
- Tianjin Orthopedic Hospital
Arms of the Study
Arm 1
Arm 2
Experimental
Placebo Comparator
Nutritional intervention group
Control group
Supplemental nutritional support is provided in addition to normal diet during the perioperative period (five days from pre- to postoperative phase). For non-diabetic patients, ENSURE is provided (Abbott; 112.6 g [12 spoon, 500 kcal]/day, twice a day); for diabetic patients, GLUCERNA SR is provided (Abbott; 104 g [12 spoon, 440 kcal]/day, twice a day).
Supplemental nutritional support is not provided in addition to normal diet during the perioperative period (five days from pre- to postoperative phase).