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Telerehabilitation for Parkinson's Disease (TelerehabPD)

Primary Purpose

Parkinson Disease, Telemedicine

Status
Completed
Phase
Not Applicable
Locations
United States
Study Type
Interventional
Intervention
Physical and occupational therapy (PT/OT)
Home Safety Evaluation (HSE)
Sponsored by
Rush University Medical Center
About
Eligibility
Locations
Arms
Outcomes
Full info

About this trial

This is an interventional treatment trial for Parkinson Disease

Eligibility Criteria

18 Years - undefined (Adult, Older Adult)All SexesDoes not accept healthy volunteers

Subject Inclusion Criteria:

  1. Subject's age is greater than or equal to 18.
  2. Subject has a diagnosis of Idiopathic Parkinson's Disease according to established criteria and this has been confirmed by a Movement Disorders Neurologist.
  3. Subject's Movement Disorders Neurologist believes he/she would benefit from specialized physical and occupational therapy to reduce fall risk.
  4. Subject's Idiopathic Parkinson's Disease is Hoehn and Yahr stage 2 or 3 in the "OFF"-medication state (stage 2 defined by bilateral or midline symptoms with less than or equal to 2 steps back on the pull test with self-recovery; stage 3 is defined by more than 2 steps back on the pull test with or without self-recovery, or no steps back and requiring assistance to recover).
  5. Subject demonstrates the ability to utilize the virtual platform at their initial in-person evaluation.
  6. Subject has been on a stable medication regimen for the treatment of Idiopathic Parkinson's Disease for the month preceding the baseline in-person visit, and has the ability to maintain stable dosing for the duration of the 10-week primary intervention.
  7. Subject has home Wi-Fi access for the tele-neurorehabilitation home visits and a personal tablet with Wi-Fi connectivity.

Care Partner Inclusion Criteria:

  1. Care partner's age is greater than or equal to 18.
  2. Care partner has been the primary caregiver for >6 months and will remain so for at least 10 weeks to the study subject.
  3. Care partner has the ability and desire to participate in all of the study visits with the study subject, including the tele-neurorehabilitation home visits.
  4. Care partner has the ability and desire to provide stand-by assistance, but in the setting of a gait belt, to the study subject during tele-neurorehabilitation home visits.

Subject Exclusion Criteria:

  1. Subject is non-English speaking.
  2. Subject has only a provisional diagnosis of Idiopathic Parkinson's Disease or atypical features suggestive of an alternative diagnosis.
  3. Subject has and additional significant neurologic diagnosis that may render him/her with neurologic deficits that may affect gait and balance.
  4. Subject has another destabilizing chronic medical condition which may warrant frequent hospitalization or render the patient unable to participate in physical activity.
  5. Subject requires more than just stand-by assistance for gait and balance.
  6. Subject is reliant on mobility devices to walk (walkers, cane, walking sticks, motorized scooter, etc).
  7. Subject is receiving physical therapy elsewhere during the month preceding the study and during the duration of the study.
  8. Subject has no care partner available to participate in all of the study visits.
  9. Subject is unable to follow direction or consent to research.
  10. Subject is unable to commit to the study-related activities and/or schedule of events.

Care Partner Exclusion Criteria:

  1. Care partner is non-English speaking.
  2. Care partner is unable to follow direction or consent to research.
  3. Care partner is unable to commit to the study-related activities and/or schedule of events.

Sites / Locations

  • Rush University Medical Center

Arms of the Study

Arm 1

Arm 2

Arm Type

Other

Other

Arm Label

TELEREHABILITATION ARM

VIRTUAL HOME SAFETY EVALUATIONS (HSE)-ONLY ARM

Arm Description

ARM 1: The TELEREHABILITATION ARM where participants receive the full originally-intended protocol that includes one initial in-person PT/OT evaluation, four virtual PT/OT visits, and one final in-person (or virtual, if in-person is not possible) PT/OT evaluation. The study duration for Arm 1 is about 10 weeks of the primary intervention as described with 3- and 6-month follow-up calls. The mobile virtual platform for Arm 1 is comprised of a tablet on a height-adjustable rotating tablet floor stand with a gooseneck and wheels.

ARM 2: The VIRTUAL HOME SAFETY EVALUTIONS (HSE)-ONLY ARM where participants ONLY receive the virtual home safety evaluations and surveillance that are built into the original protocol of three of the four tele-OT visits that is being used in Arm 1. The study duration for Arm 2 is about 6 weeks of the primary intervention as described with 3-month and 6-month follow-up calls. The mobile virtual platform for Arm 2 is comprised of a tablet OR smartphone that will be guided through the home by the care partner only and not the patient.

Outcomes

Primary Outcome Measures

Adherence Measure - 1:
(1) The proportion of scheduled protocol-driven tele-PT and tele-OT visits that were completed.
Adherence Measure - 2:
(2) The proportion of scheduled protocol-driven PT/OT exercises/activities that could be completed virtually as assessed by the instructing study therapist.
Adherence Measure - 3:
(3) Qualitative categorization of limitations in performing tele-PT and tele-OT visits and PT/OT exercises/activities virtually into patient-related, technology-related, or environmentally-related limitations
Retention Measures:
The proportion of patient and care partner (P+CP) pairs that enrolled and were able to complete the study, i.e. study drop-out rate.
Safety Measures:
The number and nature of adverse and serious adverse events that occurred due to participation in the study, and the proportion deemed a result of study-related interventions.

Secondary Outcome Measures

Goals Attainment Scale Score:
Change in Goals Attainment Scale score (GAS) from baseline across the 10-week program and at the 3- and 6-month follow-ups (Visits 1, 3, 5, 6, Follow-up Call 1-2) for 3 patient-specific PT goals under the following categories: gait/balance, strengthening, and physical endurance, and 2 patient-specific OT goals under the category of activities-of-daily-living/home safety, defined at the baseline assessment.
Falls Diary;
The change in falls frequency using the Falls Diary from baseline across the 10-week program and at the 3- and 6-month follow-ups (Visits 1, 3, 5, 6, Follow-up Call 1-2).
Activities-Specific Balance Scale:
The change in gait confidence from baseline using the Activities-Specific Balance Confidence scale (ABC scale) across the 10-week program and at the 3- and 6-month follow-ups (Visits 1, 2-6, Follow-Up Call 1-2)
Five-Times Sit-to-Stand Test:
The change in postural stability from baseline using the Five-Times Sit-to-Stand test (FTSTS) across the 10-week program to be performed both in-person and virtually (Visits 1, 3, 5, 6).
In-Person Objective Therapy Measure - 1:
The change in the following in-person assessment Mini-Balance Evaluation Systems Test (mini-BESTest) from baseline to post-intervention (Visits 1 and 6).
In-Person Objective Therapy Measure - 2:
The change in the following in-person assessment Rapid Turns Test (RTT) from baseline to post-intervention (Visits 1 and 6).
In-Person Objective Therapy Measure - 3:
The change in the following in-person assessment Timed Up and Go (TUG)from baseline to post-intervention (Visits 1 and 6).
In-Person Objective Therapy Measures - 4:
The change in the following in-person assessment Timed Up and Go-Cognitive (TUG-Cognitive) from baseline to post-intervention (Visits 1 and 6).
In-Person Objective Therapy Measure - 5:
The change in the following in-person assessment 10-Meter Walk Time (10MWT) from baseline to post-intervention (Visits 1 and 6).
In-Person Objective Therapy Measures - 6:
The change in the following in-person assessment 2-Minute Walk Distance Test (2MWT) from baseline to post-intervention (Visits 1 and 6).
Rapid Turns Test:
The change in freezing-of-gait from baseline using the Rapid Turns Test (RTT) across the 10-week program to be performed both in-person and virtually (Visits 1, 3, 5, and 6).
Parkinson's Disease Questionnaire-39:
The change in quality-of-life (QOL) using the Parkinson's Disease Questionnaire-39 (PDQ-39) from baseline to post-intervention (Visits 1 and 6).
Home Exercise Program:
The proportion of patients who were able to adhere to their recommended home exercise program (HEP) in between study visits as assessed by weekly coordinator phone calls.

Full Information

First Posted
February 7, 2020
Last Updated
September 8, 2021
Sponsor
Rush University Medical Center
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1. Study Identification

Unique Protocol Identification Number
NCT04600011
Brief Title
Telerehabilitation for Parkinson's Disease
Acronym
TelerehabPD
Official Title
A Novel Tele-Neurorehabilitation Program Aimed at Reducing Fall Risk in Parkinson's Disease Patients
Study Type
Interventional

2. Study Status

Record Verification Date
September 2021
Overall Recruitment Status
Completed
Study Start Date
January 21, 2020 (Actual)
Primary Completion Date
June 15, 2021 (Actual)
Study Completion Date
June 15, 2021 (Actual)

3. Sponsor/Collaborators

Responsible Party, by Official Title
Principal Investigator
Name of the Sponsor
Rush University Medical Center

4. Oversight

Studies a U.S. FDA-regulated Drug Product
No
Studies a U.S. FDA-regulated Device Product
No
Data Monitoring Committee
No

5. Study Description

Brief Summary
Our primary objective in this 10-week pilot study is to demonstrate the feasibility of using videoconferencing technology to provide Parkinson's Disease (PD) patients, alongside their supervising care partners, specialized physical and occupational therapy (PT/OT) focused on neurorehabilitation that ultimately aims to reduce fall risk. This therapy is similar to what a PD patient could receive in-person with neurologic-certified physical therapists and occupational therapists with significant experience working with PD patients and addressing their needs, but it is delivered through a virtual platform. Feasibility is defined by measures of adherence, retention, and safety. The specialized PT and OT measurement tools and strategies used in this study are in-line with the most current formal evidence-based guidelines/recommendations available for therapy in PD: European Physiotherapy Guideline for Parkinson's Disease, Parkinson Evidence Database to Guide Effectiveness (PD-EDGE) Task Force and Guidelines for Occupational Therapy in Parkinson's Disease Rehabilitation. The study duration is approximately 10 weeks of the primary telerehabilitation intervention and a 2 follow-up phone calls at the 3- and 6-month timepoints. There will be one baseline in-person evaluation and one final in-person evaluation following the completion of all televisits. The enrollment target is up to 15-20 patient and care partner (P+CP) pairs, meaning 30-40 subjects total. There are no controls for this study.
Detailed Description
Gait dysfunction, postural instability, and freezing-of-gait (FOG) ultimately develop in about 80% of PD patients, which lead to falls and advancing disability. This is significant because the consequences of falls are far-reaching: accelerating immobility due to heightened fear-of-falling, reducing quality of life and independence, and increasing healthcare utilization and costs. Thus, there is an urgent need to expand evidence- based outpatient neurologic-PT/OT services to community-dwelling PD patients to reduce fall risk. This research proposal will address this unmet need by determining whether tele-neurorehabilitation is a care model that can be executed safety for PD patients to provide these services from well-trained therapists who are not easily accessible otherwise. This feasibility data is critical in the development of a novel tele-neurorehabilitation protocol and randomized-controlled efficacy trial thereafter. The impact of the intended research is to demonstrate the feasibility and preliminary efficacy of this novel teleconferencing-based delivery of gait and balance exercises/strategies with guided instruction much like one would receive in-person but in the comfort of one's own home. By demonstrating the feasibility and preliminary efficacy of this pilot program, subsequent long-term goals are to apply for larger sources of funding to sustain the program. By leveraging the data gained from these studies it is anticipated the practice of telerehabilitation will be expanded and improved; and ultimately its efficacy to health care policy providers and insurers for potential reimbursement will be demonstrated. The researchers intend to enroll 15-20 individuals with mild-moderate PD into our proposed novel telerehabilitation program, where patients will receive tele-PT/OT home visits and home-safety surveillance with neurologic-specialized therapists who are experienced with the core problem areas seen in PD patients. The intended clinical impact is to improve gait/balance function and postural stability, and thus reduce falls in patients with PD. With the remote telecommunications intervention, we aim to enable the additional clinical impact of expanding access to therapy for people with PD that otherwise would have significant difficulty obtaining this type of multiple-visit, individually-tailored, and specialized therapy care due to travel burden and cost.

6. Conditions and Keywords

Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
Parkinson Disease, Telemedicine

7. Study Design

Primary Purpose
Treatment
Study Phase
Not Applicable
Interventional Study Model
Parallel Assignment
Model Description
Pilot feasibility study, non-controlled
Masking
None (Open Label)
Allocation
Non-Randomized
Enrollment
15 (Actual)

8. Arms, Groups, and Interventions

Arm Title
TELEREHABILITATION ARM
Arm Type
Other
Arm Description
ARM 1: The TELEREHABILITATION ARM where participants receive the full originally-intended protocol that includes one initial in-person PT/OT evaluation, four virtual PT/OT visits, and one final in-person (or virtual, if in-person is not possible) PT/OT evaluation. The study duration for Arm 1 is about 10 weeks of the primary intervention as described with 3- and 6-month follow-up calls. The mobile virtual platform for Arm 1 is comprised of a tablet on a height-adjustable rotating tablet floor stand with a gooseneck and wheels.
Arm Title
VIRTUAL HOME SAFETY EVALUATIONS (HSE)-ONLY ARM
Arm Type
Other
Arm Description
ARM 2: The VIRTUAL HOME SAFETY EVALUTIONS (HSE)-ONLY ARM where participants ONLY receive the virtual home safety evaluations and surveillance that are built into the original protocol of three of the four tele-OT visits that is being used in Arm 1. The study duration for Arm 2 is about 6 weeks of the primary intervention as described with 3-month and 6-month follow-up calls. The mobile virtual platform for Arm 2 is comprised of a tablet OR smartphone that will be guided through the home by the care partner only and not the patient.
Intervention Type
Other
Intervention Name(s)
Physical and occupational therapy (PT/OT)
Intervention Description
Neurologic-specialized and -certified physical and occupational therapists will provide each participant with an initial in-person PT/OT evaluation/treatment session with oversight from a Movement Disorders Neurologist, followed by 4 "virtual home visits" with tele-PT/OT and care partner supervision every 2 weeks, and culminating with a final in-person evaluation, all with a focus on personalized training in core areas contributing to a patient's individual fall risk, much like in-person visits. Virtual home safety surveillance with the mobile virtual platform is an additional feature of this intervention that aims to optimize the home environment to reduce external factors contributing to fall risk.
Intervention Type
Other
Intervention Name(s)
Home Safety Evaluation (HSE)
Intervention Description
The VIRTUAL HOME SAFETY EVALUTIONS (HSE)-ONLY ARM where participants ONLY receive the virtual home safety evaluations and surveillance that are built into the original protocol of three of the four tele-OT visits that is being used in Arm 1. The study duration for Arm 2 is about 6 weeks of the primary intervention as described with 3-month and 6-month follow-up calls. The mobile virtual platform for Arm 2 is comprised of a tablet OR smartphone that will be guided through the home by the care partner only and not the patient.
Primary Outcome Measure Information:
Title
Adherence Measure - 1:
Description
(1) The proportion of scheduled protocol-driven tele-PT and tele-OT visits that were completed.
Time Frame
Through study completion of approximately 18 months.
Title
Adherence Measure - 2:
Description
(2) The proportion of scheduled protocol-driven PT/OT exercises/activities that could be completed virtually as assessed by the instructing study therapist.
Time Frame
Through study completion of approximately 18 months.
Title
Adherence Measure - 3:
Description
(3) Qualitative categorization of limitations in performing tele-PT and tele-OT visits and PT/OT exercises/activities virtually into patient-related, technology-related, or environmentally-related limitations
Time Frame
Through study completion of approximately 18 months.
Title
Retention Measures:
Description
The proportion of patient and care partner (P+CP) pairs that enrolled and were able to complete the study, i.e. study drop-out rate.
Time Frame
Through study completion of approximately 18 months.
Title
Safety Measures:
Description
The number and nature of adverse and serious adverse events that occurred due to participation in the study, and the proportion deemed a result of study-related interventions.
Time Frame
Through study completion of approximately 18 months.
Secondary Outcome Measure Information:
Title
Goals Attainment Scale Score:
Description
Change in Goals Attainment Scale score (GAS) from baseline across the 10-week program and at the 3- and 6-month follow-ups (Visits 1, 3, 5, 6, Follow-up Call 1-2) for 3 patient-specific PT goals under the following categories: gait/balance, strengthening, and physical endurance, and 2 patient-specific OT goals under the category of activities-of-daily-living/home safety, defined at the baseline assessment.
Time Frame
Through study completion of approximately 18 months.
Title
Falls Diary;
Description
The change in falls frequency using the Falls Diary from baseline across the 10-week program and at the 3- and 6-month follow-ups (Visits 1, 3, 5, 6, Follow-up Call 1-2).
Time Frame
Through study completion of approximately 18 months.
Title
Activities-Specific Balance Scale:
Description
The change in gait confidence from baseline using the Activities-Specific Balance Confidence scale (ABC scale) across the 10-week program and at the 3- and 6-month follow-ups (Visits 1, 2-6, Follow-Up Call 1-2)
Time Frame
Through study completion of approximately 18 months.
Title
Five-Times Sit-to-Stand Test:
Description
The change in postural stability from baseline using the Five-Times Sit-to-Stand test (FTSTS) across the 10-week program to be performed both in-person and virtually (Visits 1, 3, 5, 6).
Time Frame
Through study completion of approximately 18 months.
Title
In-Person Objective Therapy Measure - 1:
Description
The change in the following in-person assessment Mini-Balance Evaluation Systems Test (mini-BESTest) from baseline to post-intervention (Visits 1 and 6).
Time Frame
Through study completion of approximately 18 months.
Title
In-Person Objective Therapy Measure - 2:
Description
The change in the following in-person assessment Rapid Turns Test (RTT) from baseline to post-intervention (Visits 1 and 6).
Time Frame
Through study completion of approximately 18 months.
Title
In-Person Objective Therapy Measure - 3:
Description
The change in the following in-person assessment Timed Up and Go (TUG)from baseline to post-intervention (Visits 1 and 6).
Time Frame
Through study completion of approximately 18 months.
Title
In-Person Objective Therapy Measures - 4:
Description
The change in the following in-person assessment Timed Up and Go-Cognitive (TUG-Cognitive) from baseline to post-intervention (Visits 1 and 6).
Time Frame
Through study completion of approximately 18 months.
Title
In-Person Objective Therapy Measure - 5:
Description
The change in the following in-person assessment 10-Meter Walk Time (10MWT) from baseline to post-intervention (Visits 1 and 6).
Time Frame
Through study completion of approximately 18 months.
Title
In-Person Objective Therapy Measures - 6:
Description
The change in the following in-person assessment 2-Minute Walk Distance Test (2MWT) from baseline to post-intervention (Visits 1 and 6).
Time Frame
Through study completion of approximately 18 months.
Title
Rapid Turns Test:
Description
The change in freezing-of-gait from baseline using the Rapid Turns Test (RTT) across the 10-week program to be performed both in-person and virtually (Visits 1, 3, 5, and 6).
Time Frame
Through study completion of approximately 18 months.
Title
Parkinson's Disease Questionnaire-39:
Description
The change in quality-of-life (QOL) using the Parkinson's Disease Questionnaire-39 (PDQ-39) from baseline to post-intervention (Visits 1 and 6).
Time Frame
Through study completion of approximately 18 months.
Title
Home Exercise Program:
Description
The proportion of patients who were able to adhere to their recommended home exercise program (HEP) in between study visits as assessed by weekly coordinator phone calls.
Time Frame
Through study completion of approximately 18 months.
Other Pre-specified Outcome Measures:
Title
APDM Mobility Lab Sensor Data:
Description
Change in measures of comprehensive gait, functional mobility, and postural sway analyses from baseline (Visit 1) to post-intervention (Visit 6) using the APDM Mobility LabTM six-inertial sensory system (APDMTM, Oregon) in the "OFF" medication state in a subset of 5-10 patients.
Time Frame
Through study completion of approximately 18 months.
Title
"Telehealth Satisfaction Survey":
Description
Qualitative assessment using Likert-based questions and qualitative assessment of the patient, care partner, and study therapists' satisfaction with and perspectives on tele-neurorehabilitation virtual home visits.
Time Frame
Through study completion of approximately 18 months.

10. Eligibility

Sex
All
Minimum Age & Unit of Time
18 Years
Accepts Healthy Volunteers
No
Eligibility Criteria
Subject Inclusion Criteria: Subject's age is greater than or equal to 18. Subject has a diagnosis of Idiopathic Parkinson's Disease according to established criteria and this has been confirmed by a Movement Disorders Neurologist. Subject's Movement Disorders Neurologist believes he/she would benefit from specialized physical and occupational therapy to reduce fall risk. Subject's Idiopathic Parkinson's Disease is Hoehn and Yahr stage 2 or 3 in the "OFF"-medication state (stage 2 defined by bilateral or midline symptoms with less than or equal to 2 steps back on the pull test with self-recovery; stage 3 is defined by more than 2 steps back on the pull test with or without self-recovery, or no steps back and requiring assistance to recover). Subject demonstrates the ability to utilize the virtual platform at their initial in-person evaluation. Subject has been on a stable medication regimen for the treatment of Idiopathic Parkinson's Disease for the month preceding the baseline in-person visit, and has the ability to maintain stable dosing for the duration of the 10-week primary intervention. Subject has home Wi-Fi access for the tele-neurorehabilitation home visits and a personal tablet with Wi-Fi connectivity. Care Partner Inclusion Criteria: Care partner's age is greater than or equal to 18. Care partner has been the primary caregiver for >6 months and will remain so for at least 10 weeks to the study subject. Care partner has the ability and desire to participate in all of the study visits with the study subject, including the tele-neurorehabilitation home visits. Care partner has the ability and desire to provide stand-by assistance, but in the setting of a gait belt, to the study subject during tele-neurorehabilitation home visits. Subject Exclusion Criteria: Subject is non-English speaking. Subject has only a provisional diagnosis of Idiopathic Parkinson's Disease or atypical features suggestive of an alternative diagnosis. Subject has and additional significant neurologic diagnosis that may render him/her with neurologic deficits that may affect gait and balance. Subject has another destabilizing chronic medical condition which may warrant frequent hospitalization or render the patient unable to participate in physical activity. Subject requires more than just stand-by assistance for gait and balance. Subject is reliant on mobility devices to walk (walkers, cane, walking sticks, motorized scooter, etc). Subject is receiving physical therapy elsewhere during the month preceding the study and during the duration of the study. Subject has no care partner available to participate in all of the study visits. Subject is unable to follow direction or consent to research. Subject is unable to commit to the study-related activities and/or schedule of events. Care Partner Exclusion Criteria: Care partner is non-English speaking. Care partner is unable to follow direction or consent to research. Care partner is unable to commit to the study-related activities and/or schedule of events.
Overall Study Officials:
First Name & Middle Initial & Last Name & Degree
Mitra Afshari, MD, MPH
Organizational Affiliation
Rush University
Official's Role
Principal Investigator
Facility Information:
Facility Name
Rush University Medical Center
City
Chicago
State/Province
Illinois
ZIP/Postal Code
60612
Country
United States

12. IPD Sharing Statement

Plan to Share IPD
No
Citations:
PubMed Identifier
30003140
Citation
Marras C, Beck JC, Bower JH, Roberts E, Ritz B, Ross GW, Abbott RD, Savica R, Van Den Eeden SK, Willis AW, Tanner CM; Parkinson's Foundation P4 Group. Prevalence of Parkinson's disease across North America. NPJ Parkinsons Dis. 2018 Jul 10;4:21. doi: 10.1038/s41531-018-0058-0. eCollection 2018.
Results Reference
background
PubMed Identifier
17377927
Citation
Macht M, Kaussner Y, Moller JC, Stiasny-Kolster K, Eggert KM, Kruger HP, Ellgring H. Predictors of freezing in Parkinson's disease: a survey of 6,620 patients. Mov Disord. 2007 May 15;22(7):953-6. doi: 10.1002/mds.21458.
Results Reference
background
PubMed Identifier
15551331
Citation
Hely MA, Morris JG, Reid WG, Trafficante R. Sydney Multicenter Study of Parkinson's disease: non-L-dopa-responsive problems dominate at 15 years. Mov Disord. 2005 Feb;20(2):190-9. doi: 10.1002/mds.20324.
Results Reference
background
PubMed Identifier
17131223
Citation
Poewe W. The natural history of Parkinson's disease. J Neurol. 2006 Dec;253 Suppl 7:VII2-6. doi: 10.1007/s00415-006-7002-7.
Results Reference
background
PubMed Identifier
25737205
Citation
Low V, Ben-Shlomo Y, Coward E, Fletcher S, Walker R, Clarke CE. Measuring the burden and mortality of hospitalisation in Parkinson's disease: A cross-sectional analysis of the English Hospital Episodes Statistics database 2009-2013. Parkinsonism Relat Disord. 2015 May;21(5):449-54. doi: 10.1016/j.parkreldis.2015.01.017. Epub 2015 Feb 17.
Results Reference
background
PubMed Identifier
15580552
Citation
Wielinski CL, Erickson-Davis C, Wichmann R, Walde-Douglas M, Parashos SA. Falls and injuries resulting from falls among patients with Parkinson's disease and other parkinsonian syndromes. Mov Disord. 2005 Apr;20(4):410-415. doi: 10.1002/mds.20347.
Results Reference
background
PubMed Identifier
12525724
Citation
Pressley JC, Louis ED, Tang MX, Cote L, Cohen PD, Glied S, Mayeux R. The impact of comorbid disease and injuries on resource use and expenditures in parkinsonism. Neurology. 2003 Jan 14;60(1):87-93. doi: 10.1212/wnl.60.1.87.
Results Reference
background

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Telerehabilitation for Parkinson's Disease

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