Muscular Rehabilitation by Eccentric Exercise After Severe COVID-19 Infection (CovExc)
Covid19, Sarcopenia, Muscle Weakness
About this trial
This is an interventional treatment trial for Covid19 focused on measuring Covid19, Sarcopenia, Muscle Weakness, Eccentric exercises, Rehabilitation
Eligibility Criteria
Inclusion Criteria:
- Male or female, 18 to 80 years old
- Diagnosed for SARS-CoV-2 infection (COVID-19) requiring a rehabilitation program at least 1 month after the hospitalization
- Autonomy in daily life activities 1 month after diagnosis
- Able to walk for 6 min (discontinuous walking possible)
- Giving informed written consent to participate in the study
- Health insurance coverage
Exclusion Criteria:
- Cardiovascular or respiratory contraindication to the rehabilitation program
- Difficulty to perform an eccentric exercise on a seated ergometer
- Pregnant or breastfeeding
- Under guardianship, curatorship or deprived of liberty
- Taking antivitamin K anticoagulation (muscle biopsy)
- Refusal to participate
Sites / Locations
- CHU de Clermont-FerrandRecruiting
- CHU de DijonRecruiting
- CHU de Saint-EtienneRecruiting
Arms of the Study
Arm 1
Arm 2
Experimental
Active Comparator
Eccentric group
Concentric group
The experimental group (eccentric) will perform 5 habituation sessions: the initial power of the exercise will be set to 10 Watts and then increased by 10% each session, depending on the muscle tolerance. The training power must correspond to 3 times that of the control group to obtain a similar metabolic stimulation and will be adapted according to the pain felt at the end of the session.
The control group (concentric) will perform exercise training at an intensity of 60% of the reserve heart rate determined during an initial cardiorespiratory test. The power will be adjusted weekly to stay within the target heart rate range.