Effect of Tranexamic Acid on Postoperative Bleeding Following Sinus and Nasal Surgery
Chronic Sinusitis, Nasal Obstruction, Turbinate; Hypertrophy Mucous Membrane
About this trial
This is an interventional prevention trial for Chronic Sinusitis
Eligibility Criteria
Inclusion Criteria:
- Scheduled to undergo elective sinus or nasal surgery (e.g. septoplasty, inferior turbinate reduction, endoscopic sinus surgery)
- Age 18 or greater
- English-speaking
- Able to provide consent
Exclusion Criteria:
- Minors (age<18)
- Pregnant or may become pregnant by time of surgery
- Prisoners
- Non-English speaking
- Foreign citizens
- Unable to provide consent
- Known pro-thrombotic coagulation disorders
- Active intranasal drug use (e.g. cocaine)
- Surgery is for a sinonasal tumor or other sinus pathology not described in inclusion criteria
- Enrollment is in conflict with existing study participation
Sites / Locations
- Stanford University
Arms of the Study
Arm 1
Arm 2
Experimental
No Intervention
1,000mg IV Tranexamic acid
Normal saline
Participants in this arm will be given a 1,000mg dose of intravenous tranexamic acid via saline infusion 15 minutes prior to the completion of surgery. They will keep a bleeding diary with daily entries each day until their first routine scheduled postoperative follow-up clinic visit one week after surgery.
Participants in this arm will not be given any extra intervention over their routine anesthetic care. They will continue to receive their normal saline infusion during surgery. They will keep a bleeding diary with daily entries each day until their first routine scheduled postoperative follow-up clinic visit one week after surgery.