Experimental Manipulation of Sleep and Circadian Rhythms and the Role Played on Reward Function in Teens (CARRS-P2)
Delayed Sleep Phase Syndrome
About this trial
This is an interventional basic science trial for Delayed Sleep Phase Syndrome focused on measuring adolescence, sleep, substance use, reward sensitivity and motivation, circadian phase and alignment, inhibition
Eligibility Criteria
Inclusion Criteria:
- Typically enrolled in a traditional high-school with synchronous learning (in-person or online synchronous learning, but not cyber- or home-schooling) [school closures during the COVID-19 pandemic are an exception to this]
- Physically and psychiatrically healthy
- Provision of written informed consent and assent
- Additional inclusion criterion for Experimental protocol: Meets operational definition of late sleep timing (>11:15PM habitual bedtime)
Exclusion Criteria:
- History of alcohol, cannabis, or illicit drug use in the past month, or greater than monthly use in the past year
- Significant or unstable acute or chronic medical conditions
- Frequent headaches or migraines
- History of seizures
- Current serious psychiatric disorder (e.g., depressive disorder, bipolar disorder, eating disorder, psychotic disorder diagnosis, alcohol use disorder or substance use disorder) that would interfere with completion of study procedures
- Family history of bipolar disorder among first degree relative
- Current syndromal sleep disorders other than insomnia and delayed sleep phase disorder
- MRI contraindications (ie, absence of metal in the body, pregnancy, claustrophobia)
- Pregnancy
- Medications that increase sensitivity to blue light/photosensitizing medications, including psychiatric neuroleptic drugs, psoralen drugs, antiarrhythmic drugs, etc.
- Changes to psychotropic medication regimen in the 2 weeks prior to enrollment, and/or major changes to medications during the study protocol
- If participants have an average bedtime that is later than 3:00AM or an average wake time later than 11:00AM they cannot participate in the study
- Participants should be EXCLUDED for other sleep disorders that require ongoing treatment
- Participants should be EXCLUDED for other sleep disorders that cause significant distress or impairment, per DSM 5 criteria in the Sleep SCID.
Sites / Locations
- Western Psychiatric HospitalRecruiting
Arms of the Study
Arm 1
Arm 2
Experimental
Active Comparator
Advance/Extend Manipulation
Control
For ~2 weeks, Advance/Extend participants will advance bedtime and regularize wake time. The first night of the manipulation will be conducted in the lab under tightly-controlled experimental conditions. Participants will then go home and for the next 12 days will be instructed to: Sleep scheduling-- advance bedtime by 1.5 hours ( + sleep duration) Decrease evening blue light exposure via blue blocker goggles (2 hrs before bed) Increase morning bright light exposure via bright light goggles (30 min after rise) Monitor sleep, mood, and substance use via smartphone-based platform and wrist actigraph
Control participants will complete the baseline laboratory study, then maintain their habitual sleep schedules over the next 13 days at home, with no instruction on sleep timing or light exposure. Control participants will complete smartphone-and text-based assessments, thereby controlling for effort.