A Study to Evaluate Efficacy and Safety of ALN-AGT01 in Patients With Mild To-Moderate Hypertension (KARDIA-1) (KARDIA-1)
Hypertension

About this trial
This is an interventional treatment trial for Hypertension focused on measuring High blood pressure, Hypertension, Hypertensive, siRNA, Angiotensinogen, AGT
Eligibility Criteria
Inclusion Criteria:
- Daytime mean SBP ≥135 mmHg and ≤160 mmHg by ABPM, without antihypertensive medication
Exclusion Criteria:
- Secondary hypertension, orthostatic hypotension
- Alanine aminotransferase (ALT) or aspartate aminotransferase (AST) >2× upper limit of normal (ULN)
- Elevated potassium >5 mEq/L
- Estimated glomerular filtration rate (eGFR) of ≤30 mL/min/1.73m^2
- Received an investigational agent within the last 30 days
- Type 1 diabetes mellitus, poorly controlled Type 2 diabetes mellitus, newly diagnosed Type 2 diabetes mellitus
- History of any cardiovascular event within 6 months prior to randomization
- History of intolerance to SC injection(s)
Sites / Locations
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Arms of the Study
Arm 1
Arm 2
Arm 3
Arm 4
Arm 5
Experimental
Experimental
Experimental
Experimental
Placebo Comparator
ALN-AGT01 Dose Regimen 1
ALN-AGT01 Dose Regimen 2
ALN-AGT01 Dose Regimen 3
ALN-AGT01 Dose Regimen 4
Placebo + ALN-AGT01
Multiple doses of ALN-AGT01 administered by subcutaneous (SC) injection during the 12-month DB treatment period.
Multiple doses of ALN-AGT01 administered by SC injection during the 12-month DB treatment period.
Multiple doses of ALN-AGT01 administered by SC injection during the 12-month DB treatment period.
Multiple doses of ALN-AGT01 administered by SC injection during the 12-month DB treatment period.
Multiple doses of placebo administered by SC injection during the first 6 months of 12-month DB treatment period, followed by multiple doses of ALN-AGT01 administered by SC injection during the last 6 months of the 12-month DB treatment period.