High Fiber in Parkinson's Disease

This is an interventional other trial for Parkinson Disease Read More

Inclusion Criteria:

• Parkinson's disease patients who are untreated

Exclusion Criteria:

• Occupation expected to change the microbiome (e.g. sanitation worker)
• Treatment with medications that may induce parkinsonism (e.g. metoclopramide, typical or atypical antipsychotic agents)
• Treatment within 12 weeks with oral or intravenous antibiotics
• Known diagnosis of inflammatory bowel disease
• Symptomatic organic gastrointestinal (GI) disease (other than hemorrhoids and hiatal hernia) or abdominal surgeries for symptomatic gastrointestinal disease such as bowel resection, diverticular surgery, colostomy; subjects with a history of an appendectomy or gallbladder removal for non-cancerous disease more than 5 years prior to presentation are allowed.
• Symptomatic functional GI disease that significantly impairs intestinal motility such as scleroderma or use of GI motility drugs
• Acute illness requiring immediate hospitalization
• Pre-existent conditions as below:
• Liver disease (cirrhosis or persistently abnormal AST or ALT that are 2X> normal);
• Kidney disease (creatinine>2.0 mg/dL);
• Uncontrolled psychiatric illness;
• Clinically important lung disease or heart failure;
• HIV disease;
• Alcoholism, unreliable drinking history; or consumption of alcohol more than 3 times a week or binge drinking or drinking more than or equal to 3 drinks per occasion;
• Transplant recipients;
• Diabetes;
• BMI > 30
• Clinically significant dehydration or clinically detectable ascites or peripheral edema or cardiac failure
• Presence of short bowel syndrome or severe malnutrition with ideal body weight < or = 90%
• Use of immunosuppressive medications in 3 months prior to enrollment
• Anti-inflammatory medication use within 3 weeks of enrollment.
• Chronic use of diuretics