Longitudinal Multi-Omic Profiles to Reveal Mechanisms of Obesity-Mediated Insulin Resistance
Diabetes Mellitus, Type 2, PreDiabetes, Insulin Resistance
About this trial
This is an interventional prevention trial for Diabetes Mellitus, Type 2 focused on measuring Metabolomics, Low Fat Diet, Low Carbohydrate Diet, Microbiome
Eligibility Criteria
Inclusion Criteria:
- Age 35-65
- BMI 25-35 kg/m2
- Stable body weight
- Nondiabetic
Exclusion Criteria:
Patients with;
- diabetes
- major organ disease
- history of liposuction or bariatric surgery
- active eating or psychiatric disorder
- pregnancy or lactation, heavy alcohol use
- recent change in weight (over the past 12 weeks)
- use of weight loss medication, statins, or oral steroids
Clinical screening exclusions;
- hematocrit < 33%
- fasting glucose >/= 126 mg/dL
- blood pressure >160/100 mmHg
Sites / Locations
- Stanford UniversityRecruiting
Arms of the Study
Arm 1
Arm 2
Arm 3
Experimental
Experimental
Experimental
Mediterranean Low Carbohydrate Diet
Standard Low Carbohydrate Diet
Low Fat, Healthy Carbohydrate Diet
Assigned participants will receive instruction by a registered dietitian on a diet that is high in unsaturated fats and low in carbohydrates. Total caloric intake will be adjusted to induce a supervised metabolic challenge defined as weight gain of approximately 2.5 kg over 5 weeks followed by 3-5kg weight loss over 8 weeks.
Assigned participants will receive instruction by a registered dietitian on a low carbohydrate diet that is high in fats found in the typical American diet. Total caloric intake will be adjusted to induce a supervised metabolic challenge defined as weight gain of approximately 2.5 kg over 5 weeks followed by 3-5kg weight loss over 8 weeks.
Assigned participants will receive instruction by a registered dietitian on a low fat diet that is high in complex carbohydrates. Total caloric intake will be adjusted to induce a supervised metabolic challenge defined as weight gain of approximately 2.5 kg over 5 weeks followed by 3-5kg weight loss over 8 weeks.