Use of Direct Peritoneal Resuscitation in High-risk Liver Transplant Recipients
End Stage Liver DIsease, Obesity, Acute Kidney Injury
About this trial
This is an interventional prevention trial for End Stage Liver DIsease focused on measuring Liver transplant, Obesity, Renal failure
Eligibility Criteria
Inclusion Criteria:
- Adult liver transplant recipients ≥18 y/o
- Ability to consent
- Pre-operative Creatinine ≥1.1 (or on dialysis) and BMI ≥30
Exclusion Criteria:
- Diaphragmatic injury
- Active spontaneous bacterial peritonitis (SBP) with initiation of antibiotic treatment within 72 hours of surgery
Sites / Locations
- UCHealth - Anschutz Medical Campus
Arms of the Study
Arm 1
Experimental
Direct Peritoneal Resuscitation (DPR) Group
At the time of abdominal closure and determination that the patient will either go to extended stay or the intensive care unit, three drains will be placed per standard of care. An additional 19 French drain will be placed at the ligament of Treitz at the base of the mesentery. Following abdominal closure DPR will be initiated with commercially available 2.5% glucose-based peritoneal dialysis solution at a rate of 1.5 cc/kg/hr based on previously reported therapy in trauma. Drains will be connected to continuous wall suction. This infusion will continue for the duration the patients stay in extended stay (8 hours) if they are deemed eligible for hospital ward admission, or for 24 hours if requiring ICU care. These patients will then be observed for their hospital course and monitored for outcomes listed above.