The Response to Atropine Drops (RAD) Study

After being informed about the study and potential risks, all participants giving written informed consent will answer questions about themselves and complete a 12-question survey about the need for drama. An examiner will then measure the sensitivity of the cornea (clear window on the front of the eye) by touching the cornea with a thin thread that shortens until it is first detected by the participant. After that, an examiner will place a drop of atropine in the right eye, and the participant will rate the eye comfort for 25 seconds using a computerized slide scale. Five minutes after the first drop, the examiner will put a drop in the left eye and the participant will rate the comfort for 25 seconds. The examiner will then repeat that process one more time with each eye. The drops placed in the eyes will be 0.01% atropine at room temperature from Lab A, 0.05% atropine at room temperature from Lab A, 0.05% atropine refrigerated from Lab A, or 0.05% atropine at room temperature from Lab B. The drops will be placed in the eyes in random order, so the participant won't know which one is being administered. At the very end, the participant will rate how likely s/he would be to take a low concentration atropine eye drop every day in each eye if it may delay the onset of nearsightedness from 1 (definitely not) to 10 (definitely would).

Participants will have one drop of low concentration atropine placed in one eye four different times in random order

We will compare the amount of time that it takes a participant to report that the eye comfort is "0," meaning that it returned to baseline comfort, for the following drop comparisons: 0.01% at room temperature from Lab A and 0.05% at room temperature from Lab A (comparing concentrations) 0.05% at room temperature from Lab A and 0.05% refrigerated from Lab A (comparing temperatures) 0.05% at room temperature from Lab A and 0.05% at room temperature from Lab B (comparing labs)

We will compare the proportion of participants who report the eye comfort is "0," meaning that it returned to baseline comfort, for the following drop comparisons: 0.01% at room temperature from Lab A and 0.05% at room temperature from Lab A (comparing concentrations) 0.05% at room temperature from Lab A and 0.05% refrigerated from Lab A (comparing temperatures) 0.05% at room temperature from Lab A and 0.05% at room temperature from Lab B (comparing labs) Comfort scale ranges from 0 (no discomfort) to 10 (extreme discomfort)

We will compare the peak comfort score, meaning the most discomfort, for the following drop comparisons: 0.01% at room temperature from Lab A and 0.05% at room temperature from Lab A (comparing concentrations) 0.05% at room temperature from Lab A and 0.05% refrigerated from Lab A (comparing temperatures) 0.05% at room temperature from Lab A and 0.05% at room temperature from Lab B (comparing labs) Comfort scale ranges from 0 (no discomfort) to 10 (extreme discomfort)

We will compare the average comfort score over 25 seconds for the following drop comparisons: 0.01% at room temperature from Lab A and 0.05% at room temperature from Lab A (comparing concentrations) 0.05% at room temperature from Lab A and 0.05% refrigerated from Lab A (comparing temperatures) 0.05% at room temperature from Lab A and 0.05% at room temperature from Lab B (comparing labs) Comfort scale ranges from 0 (no discomfort) to 10 (extreme discomfort)

We will determine the correlation coefficient between the peak pain score when taking 0.05% atropine at room temperature from Lab A and corneal sensitivity Comfort scale ranges from 0 (no discomfort) to 10 (extreme discomfort)

We will determine the correlation coefficient between the peak pain score when taking 0.05% atropine at room temperature from Lab A and iris color Comfort scale ranges from 0 (no discomfort) to 10 (extreme discomfort)

We will determine the correlation coefficient between the peak pain score when taking 0.05% atropine at room temperature from Lab A and the Persistent Perceived Victim scale score of the Need for Drama Survey Comfort scale ranges from 0 (no discomfort) to 10 (extreme discomfort)