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Hashtag HPV: HPV Vaccine Twitter Education Program

Primary Purpose

Human Papilloma Virus, Vaccine-Preventable Diseases

Status
Active
Phase
Not Applicable
Locations
United States
Study Type
Interventional
Intervention
HPV Twitter Education Program - Narrative
HPV Twitter Education Program - Non-Narrative
Sponsored by
University of Arkansas, Fayetteville
About
Eligibility
Locations
Arms
Outcomes
Full info

About this trial

This is an interventional prevention trial for Human Papilloma Virus focused on measuring Human Papilloma Virus, Human Papilloma Virus Vaccine, Human Papilloma Virus Vaccination, Intervention, Social media, Twitter, Parents, Child health, Cancer prevention, Vaccine acceptance, Narrative engagement, Patient self-report, Intention to vaccinate, community engagement, Public Health, Vaccination

Eligibility Criteria

18 Years - undefined (Adult, Older Adult)All SexesAccepts Healthy Volunteers

Inclusion Criteria: The study population includes parents who have children ages 9-14. All participants will be 18 years of age or older, and we will specifically target parents ages 25 and older. Eligibility for enrollment in the study will be limited to the following criteria:

  1. Adults 18 years of age and older;
  2. Utilizes Twitter, a social media platform;
  3. Has a child aged 9-14;
  4. Child has not started the 2-dose HPV vaccination series;
  5. Has no child who has completed any dose HPV vaccination series;
  6. Has a well-care visit scheduled for their child before December, 2022.

Exclusion Criteria:

  1. Any adult who does not have a child 9-14 years of age;
  2. Any adult who does not indicate some level of participation in Twitter;
  3. Any adults who indicates a high level of anti-vaccine sentiment (assessed by vaccine hesitancy questions asked in the screener).

Sites / Locations

  • University of Arkansas

Arms of the Study

Arm 1

Arm 2

Arm Type

Experimental

Active Comparator

Arm Label

Narrative

Non-Narrative

Arm Description

The intervention condition will present narrative-focused messages about HPV and the HPV vaccine that includes important parent focused exemplar language and cultural norms on Twitter told through stories and characters (i.e., pseudo-parents).

The non-narrative condition will present scientific-focused messages about HPV and the HPV vaccine that includes important information relayed with numbers and facts.

Outcomes

Primary Outcome Measures

Change in caregiver self-reported HPV vaccination status of child questionnaire
dependent variable; measure collects date of vaccination and number of vaccine doses to date
Change in caregiver self-reported HPV vaccination status of child questionnaire
dependent variable; measure collects date of vaccination and number of vaccine doses to date

Secondary Outcome Measures

Caregiver self-reported empathy subscale adapted from Busselle & Bilandzic (2009) and Murphy, Frank, Chatterjee, Baezconde-Garbanati (2013).
mediating/moderating variable
Caregiver self-reported transportation subscale adapted from Murphy, Frank, Chatterjee, Baezconde-Garbanati (2013). Narrative versus Non-narrative: The Role of Identification, Transportation and Emotion in Reducing Health Disparities.
mediating/moderating variable
Caregiver self-reported identification subscale adapted from Murphy, Frank, Chatterjee, Baezconde-Garbanati (2013). Narrative versus Non-narrative: The Role of Identification, Transportation and Emotion in Reducing Health Disparities.
mediating/moderating variable
Change in caregiver self-reported intention to vaccinate their child questionnaire
dependent variable; measures readiness and likeliness to receive HPV vaccination
Change in caregiver self-reported intention to vaccinate their child questionnaire
dependent variable; measures readiness and likeliness to receive HPV vaccination

Full Information

First Posted
December 9, 2021
Last Updated
January 26, 2023
Sponsor
University of Arkansas, Fayetteville
Collaborators
Thomas Jefferson University, University at Albany, National Cancer Institute (NCI), University of California, Los Angeles
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1. Study Identification

Unique Protocol Identification Number
NCT05204030
Brief Title
Hashtag HPV: HPV Vaccine Twitter Education Program
Official Title
Hashtag HPV: Engaging Parents Through Social Media to Increase HPV Vaccination
Study Type
Interventional

2. Study Status

Record Verification Date
January 2023
Overall Recruitment Status
Active, not recruiting
Study Start Date
December 13, 2021 (Actual)
Primary Completion Date
August 30, 2023 (Anticipated)
Study Completion Date
August 30, 2023 (Anticipated)

3. Sponsor/Collaborators

Responsible Party, by Official Title
Sponsor
Name of the Sponsor
University of Arkansas, Fayetteville
Collaborators
Thomas Jefferson University, University at Albany, National Cancer Institute (NCI), University of California, Los Angeles

4. Oversight

Studies a U.S. FDA-regulated Drug Product
No
Studies a U.S. FDA-regulated Device Product
No
Data Monitoring Committee
No

5. Study Description

Brief Summary
Parents use social media as an important parenting tool and source for health information. Using social media data to examine public opinion has had an early impact in public health and in cancer control and prevention efforts, including about the human papillomavirus (HPV) vaccine. A next step in this area of research is to develop and share messages on social media with parents to help inform and educate them about the HPV vaccine - ultimately assisting them with their decision to vaccinate their child. This study will evaluate the efficacy of social media messages through Twitter, using a randomized controlled trial to determine what types of messages resonate with parents. The investigators will examine differences between two types of messages - narrative messages (i.e., stories) and non-narrative messages (i.e., numbers and facts).
Detailed Description
Approximately 80 million people in the United States - or about one in four - are infected with human papillomavirus (HPV). HPV can cause cancer and there are vaccines that protect against cancer-related strains. Evidence supporting vaccine efficacy and safety is robust, and vaccine availability is widespread; however coverage rates continue to fall short of the national goal of 80% (48.6% in 2017). Understanding the barriers to vaccine acceptance, particularly related to parent resistance and their informational needs, is key to strengthening vaccine uptake among adolescents. Communicating evidence to parents and engaging them through narrative strategies may address some of the barriers during the decision-making process. Parents use social media as an important parenting tool and useful source for health information. In 2015, 75% of all parents used social media, and of these 1 in 4 used Twitter - equating to millions of parent users. The investigators know that using social media data for surveillance has had early impact in public health. However, what is not known is the effectiveness of using large-scale social media data to inform a targeted social media intervention to support HPV vaccine uptake. This study will advance the growing field by evaluating the efficacy of an innovative narrative-focused intervention designed to communicate evidence and information about the HPV vaccine for parents who use social media as a health information source. The approach is informed by narrative engagement theory that posits narratives strengthen knowledge and promote engagement through storytelling by tapping into feelings of empathy, identification, and transportation. The investigators will evaluate the efficacy of our Twitter-based pilot intervention in a randomized controlled trial that will enroll 600 parents/caregivers of children ages 9-14, whose child(ren) has not started the vaccine series. Our central hypothesis is that exposure to narrative-focused exemplar messages will lead to greater intention to vaccinate, and subsequently increased rates of vaccination in the intervention group compared to parents in the comparison group, who receive non-narrative HPV vaccine information (i.e., existing HPV vaccine information developed for Twitter). The investigators will use a Twitter-based Community Advisory Board, virtual focus groups, and existing Twitter messages developed by the HPV Roundtable to inform narrative-focused message development. The proposed study will address three specific aims: 1) Develop narrative-focused scientific exemplars for HPV vaccine communication utilizing existing online messages and community engagement on Twitter; 2) Quantify differences in engagement, intention to vaccinate, and self-reported vaccination between parents exposed to the narrative-focused scientific exemplars and parents exposed to non-narrative scientific messages; 3) Collect and analyze longitudinal participant metadata to measure Twitter activity during the study period. This study will impact the field of cancer prevention generally and HPV vaccination specifically by establishing the efficacy of narrative-focused health messaging campaign on social media, using a Twitter-based parent-engagement strategy.

6. Conditions and Keywords

Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
Human Papilloma Virus, Vaccine-Preventable Diseases
Keywords
Human Papilloma Virus, Human Papilloma Virus Vaccine, Human Papilloma Virus Vaccination, Intervention, Social media, Twitter, Parents, Child health, Cancer prevention, Vaccine acceptance, Narrative engagement, Patient self-report, Intention to vaccinate, community engagement, Public Health, Vaccination

7. Study Design

Primary Purpose
Prevention
Study Phase
Not Applicable
Interventional Study Model
Parallel Assignment
Model Description
This 4-year study will evaluate the efficacy of a Twitter-based pilot intervention through a randomized controlled trial that will enroll a total of 600 parents/caregivers of children ages 9-14, whose child(ren) has not started the vaccine series. The intervention will consist of 2 arms and 12 monthly cohorts. After enrollment in the project, 300 participants will be randomized into the intervention arm and 300 participants will be enrolled into the control arm. Participants will be presented the intervention one month before their child's next wellcare visit.
Masking
Participant
Allocation
Randomized
Enrollment
600 (Anticipated)

8. Arms, Groups, and Interventions

Arm Title
Narrative
Arm Type
Experimental
Arm Description
The intervention condition will present narrative-focused messages about HPV and the HPV vaccine that includes important parent focused exemplar language and cultural norms on Twitter told through stories and characters (i.e., pseudo-parents).
Arm Title
Non-Narrative
Arm Type
Active Comparator
Arm Description
The non-narrative condition will present scientific-focused messages about HPV and the HPV vaccine that includes important information relayed with numbers and facts.
Intervention Type
Other
Intervention Name(s)
HPV Twitter Education Program - Narrative
Intervention Description
This study will evaluate the efficacy of social media messages through Twitter, using a randomized controlled trial to determine what types of messages resonate with parents. The investigators will examine narrative messages (i.e., stories). The central hypothesis is that parents who read narrative-focused messages will be more likely to report narrative engagement, intention to vaccinate their child, and self-reported vaccination compared to parents who read non-narrative messages.
Intervention Type
Other
Intervention Name(s)
HPV Twitter Education Program - Non-Narrative
Intervention Description
This study will evaluate the efficacy of social media messages through Twitter, using a randomized controlled trial to determine what types of messages resonate with parents. The investigators will examine non-narrative messages (i.e., scientific information - numbers and facts). The central hypothesis is that parents who read narrative-focused messages will be more likely to report narrative engagement, intention to vaccinate their child, and self-reported vaccination compared to parents who read non-narrative messages.
Primary Outcome Measure Information:
Title
Change in caregiver self-reported HPV vaccination status of child questionnaire
Description
dependent variable; measure collects date of vaccination and number of vaccine doses to date
Time Frame
Change in caregiver self-reported HPV vaccination of child at 1-month follow-up from baseline
Title
Change in caregiver self-reported HPV vaccination status of child questionnaire
Description
dependent variable; measure collects date of vaccination and number of vaccine doses to date
Time Frame
Change in caregiver self-reported HPV vaccination of child at 1-year follow-up from 1-month follow-up
Secondary Outcome Measure Information:
Title
Caregiver self-reported empathy subscale adapted from Busselle & Bilandzic (2009) and Murphy, Frank, Chatterjee, Baezconde-Garbanati (2013).
Description
mediating/moderating variable
Time Frame
only at 1-month post intervention
Title
Caregiver self-reported transportation subscale adapted from Murphy, Frank, Chatterjee, Baezconde-Garbanati (2013). Narrative versus Non-narrative: The Role of Identification, Transportation and Emotion in Reducing Health Disparities.
Description
mediating/moderating variable
Time Frame
only at 1-month post intervention
Title
Caregiver self-reported identification subscale adapted from Murphy, Frank, Chatterjee, Baezconde-Garbanati (2013). Narrative versus Non-narrative: The Role of Identification, Transportation and Emotion in Reducing Health Disparities.
Description
mediating/moderating variable
Time Frame
only at 1-month post intervention
Title
Change in caregiver self-reported intention to vaccinate their child questionnaire
Description
dependent variable; measures readiness and likeliness to receive HPV vaccination
Time Frame
Change in caregiver self-reported intention to vaccinate their child at 1-month follow-up from baseline
Title
Change in caregiver self-reported intention to vaccinate their child questionnaire
Description
dependent variable; measures readiness and likeliness to receive HPV vaccination
Time Frame
Change in caregiver self-reported intention to vaccinate their child at 1-year follow-up from 1-month follow-up

10. Eligibility

Sex
All
Minimum Age & Unit of Time
18 Years
Accepts Healthy Volunteers
Accepts Healthy Volunteers
Eligibility Criteria
Inclusion Criteria: The study population includes parents who have children ages 9-14. All participants will be 18 years of age or older, and we will specifically target parents ages 25 and older. Eligibility for enrollment in the study will be limited to the following criteria: Adults 18 years of age and older; Utilizes Twitter, a social media platform; Has a child aged 9-14; Child has not started the 2-dose HPV vaccination series; Has no child who has completed any dose HPV vaccination series; Has a well-care visit scheduled for their child before December, 2022. Exclusion Criteria: Any adult who does not have a child 9-14 years of age; Any adult who does not indicate some level of participation in Twitter; Any adults who indicates a high level of anti-vaccine sentiment (assessed by vaccine hesitancy questions asked in the screener).
Overall Study Officials:
First Name & Middle Initial & Last Name & Degree
Philip M Massey, PhD, MPH
Organizational Affiliation
University of California, Los Angeles
Official's Role
Study Director
Facility Information:
Facility Name
University of Arkansas
City
Fayetteville
State/Province
Arkansas
ZIP/Postal Code
72701
Country
United States

12. IPD Sharing Statement

Plan to Share IPD
No
IPD Sharing Plan Description
There is not a plan to make IPD available.
Citations:
PubMed Identifier
33270038
Citation
Massey PM, Kearney MD, Hauer MK, Selvan P, Koku E, Leader AE. Dimensions of Misinformation About the HPV Vaccine on Instagram: Content and Network Analysis of Social Media Characteristics. J Med Internet Res. 2020 Dec 3;22(12):e21451. doi: 10.2196/21451.
Results Reference
background
PubMed Identifier
34295614
Citation
Massey PM, Togo E, Chiang SC, Klassen AC, Rose M, Manganello JA, Leader AE. Identifying HPV vaccine narrative communication needs among parents on social media. Prev Med Rep. 2021 Jul 7;23:101488. doi: 10.1016/j.pmedr.2021.101488. eCollection 2021 Sep.
Results Reference
background
PubMed Identifier
34713151
Citation
Massey PM, Chiang SC, Rose M, Murray RM, Rockett M, Togo E, Klassen AC, Manganello JA, Leader AE. Development of Personas to Communicate Narrative-Based Information About the HPV Vaccine on Twitter. Front Digit Health. 2021 Aug 4;3:682639. doi: 10.3389/fdgth.2021.682639. eCollection 2021.
Results Reference
background
Links:
URL
https://hashtaghpv.com/
Description
Project website for Project Hashtag HPV

Learn more about this trial

Hashtag HPV: HPV Vaccine Twitter Education Program

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