Individual Dosing of Levothyroxine After Thyroidectomy
Thyroid Neoplasms, Hypothyroidism, Surgery
About this trial
This is an interventional treatment trial for Thyroid Neoplasms focused on measuring levothyroxine, thyroidectomy, thyroid hormone replacement therapy, individualized therapy, regression model
Eligibility Criteria
Inclusion Criteria:
- patients underwent total/near-total thyroidectomy or completion thyroidectomy; patients with benign disease, or low-risk differentiated thyroid cancer, or medullary thyroid cancer who don't need TSH suppressive therapy;
Exclusion Criteria:
- patients with heart disease or severe liver/kidney insufficiency; patients taking liothyronine in addition to levothyroxine;
Sites / Locations
- Second Affiliated Hospital Zhejiang University School of MedicineRecruiting
Arms of the Study
Arm 1
Arm 2
Experimental
Active Comparator
Poisson regression model dosing scheme
weight-based dosing scheme
daily levothyroxine dose=e[2.02+0.01(W)-0.0037(A )-0.098(F)-0.01(B)+0.007(T)+0.108(I)-0.014(M), where W is the weight of the patient (Kg), A is the age of the patient (years), and F is the gender (for women 1, male is 0), B represents the patient's body mass index (BMI), T represents the preoperative TSH level, I represents whether the patient takes iron preparations (1, if not 0), M represents whether the patient takes multivitamins/minerals (1, if not 0).
daily levothyroxine dose=1.6 μg /kg/d