Electrical Stimulation of the Peripheral Vestibular System in Order to Develop a Vestibular Implant
Vestibular Disorder, Bilateral Vestibulopathy, Bilateral Vestibular Loss
About this trial
This is an interventional basic science trial for Vestibular Disorder focused on measuring Vestibular, Prosthesis, Otorhinolaryngologic Diseases, Electrical Stimulation, Vestibular Implant
Eligibility Criteria
Inclusion Criteria:
- Patients implanted with a vestibular implant showing neither auditory function nor vestibular one.
- Control group of patients implanted with a cochlear implant and presenting a normal vestibular function.
- Control group of patients with bilateral vestibular loss.
- Control group of patients with unilateral vestibular loss and finally
- Control group of healthy subjects with normal auditory and vestibular functions.
All sujbects included in the study will be older than 18 years old.
Exclusion Criteria:
- Children
- Patients suffering from blindness,
- Patients suffering from major ophtalmologic damage
- Patients suffering from neurologic disorder.
Sites / Locations
- Geneva University HospitalsRecruiting
Arms of the Study
Arm 1
Arm 2
Arm 3
Arm 4
Arm 5
Experimental
Active Comparator
Active Comparator
Active Comparator
No Intervention
Modified cochlear implant recipients
Cochlear Implant Patients (CI)
Bilateral vestibulopathy Patients (BV)
Unilateral vestibulopathy Patients (UV)
Healthy Subjects (HS)
Patients suffering from severe to profound hearing loss and severe bilateral vestibulopathy implanted with a modified cochlear implant providing 1 to 3 extracochlear electrodes implanted in proximity to the ampullary branches of the vestibular nerve (vestibular electrodes). All experiments will be carried out while the vestibular electrodes are inactive, and while electrical stimulation is delivered to one or several vestibular electrodes, with and without concurrent cochlear stimulation.
Unilateral or bilateral cochlear implant recipients with normal vestibular function documented within the clinical follow up of their cochlear implant, and without previous history of vestibular symptoms or complaints.
Patients with documented diagnosis of bilateral vestibulopathy, according to the guidelines of the Barany society (Strupp et al., Journal of Vestibular Research, vol. 27, no. 4, pp. 177-189, 2017).
Patients with documented diagnosis of unrecovered unilateral vestibulopathy, consistent with the current classification of vestibular disorders of the Bárány Society (www.jvr-web.org/ICVD.html).
Normal auditory functiona and without previous auditory or vestibular symptoms or complaints. Normal vestibular function documented with the video-head impulse test.