Absorption of Antibiotics With High Oral Bioavailability in Short-bowel Syndrome (GRAAL)
Short Bowel Syndrome, Infection, Bacterial
About this trial
This is an interventional treatment trial for Short Bowel Syndrome
Eligibility Criteria
Inclusion Criteria:
- Short bowel syndrome
- Treated for a documented infection with antibiogram by amoxicillin (+/- clavulanic acid)or ofloxacin or levofloxacin or sulfamethoxazole/trimethoprim
- Hospitalized in the Nutritional Assistant Unit or the Infectiology Unit of the Regional University Hospital of Nancy
- Affiliated to a social security system
- Having received an physical examination before entering study
- Having received full information regarding the study organization and having signed the informed consent
Exclusion Criteria:
- Patient at risk of worsening their oral absorption abilities during study
- Patient requiring dialysis
- Women of childbearing age without efficient birth control
- Allergy to any of the drugs tested
- Person concerned by Articles L. 1121-5, L. 1121-7 et L1121-8 of the Code of public health
- Person deprived of liberty or person undergoing psychiatric care pursuant to articles L. 3212-1 et L. 3213-1
Sites / Locations
- CHRU NancyRecruiting
Arms of the Study
Arm 1
Arm 2
Arm 3
Arm 4
Experimental
Experimental
Experimental
Experimental
Amoxicillin
Ofloxacin
Levofloxacin
Sulfamethoxazole trimethoprim
Each patient will receive the IV antibiotic required to treat the infection, and after the proper duration of the IV antibiotic is over, the patient will receive a few days of the oral version of the same antibiotic.
Each patient will receive the IV antibiotic required to treat the infection, and after the proper duration of the IV antibiotic is over, the patient will receive a few days of the oral version of the same antibiotic.
Each patient will receive the IV antibiotic required to treat the infection, and after the proper duration of the IV antibiotic is over, the patient will receive a few days of the oral version of the same antibiotic.
Each patient will receive the IV antibiotic required to treat the infection, and after the proper duration of the IV antibiotic is over, the patient will receive a few days of the oral version of the same antibiotic.