Targeting DNA-methylation Fingerprints Linked to Ultra-Processed Foods Consumption to Prevent Non-communicable Diseases: the METHYL-UP Study (METHYL-UP)
Obesity, Overweight
About this trial
This is an interventional prevention trial for Obesity focused on measuring Epigenetics, Methylation, Clinical trial, Causal inference, Non-communicable diseases, Precision nutrition, Ultra-processed food, NOVA, Obesity
Eligibility Criteria
Inclusion Criteria:
- Men/women
- 18-50 years old
- BMI 25-40 Kg/m2
- UPF consumption > 35% of total intake in g/day
Exclusion Criteria:
- Pregnancy
- Menopause
- IMC <25 Kg/m2 or > 40 Kg/m2
- Excessive alcohol consumption
- Prevalent cardiovascular, renal, lung, pancreatic or liver disease
- Type 1 diabetes
- Type 2 diabetes with poor glucose control or unstable medication during last 3 months
- Prevalent endocrine disease
- Changes in anti-hypertensive medication during last 3 months
- Insulin, systemic anti-inflammatory, or glucocorticoid medication during last 3 months
- Food allergies or intolerances
- Psychosocial or cultural factors that prevent from following the intervention
Sites / Locations
- IMDEA Food
Arms of the Study
Arm 1
Arm 2
Active Comparator
Experimental
Control Group
Intervention group
Participants in the control group will be provided with nutritional guidelines to follow a healthy diet based on a Mediterranean diet.
Participants in the intervention group will follow a nutritional intervention program aimed to reduce UPF consumption. Nutritional intervention will not modify basal caloric intake but will record energy intake along the intervention. Nutritional counseling will be based on nutritional educational material such as encouraged and discouraged food items, recipes, menus and food shopping lists based on unprocessed or minimally processed foods.