NOVAPAK Nasal Packing in Shellfish Allergic Patients
Shellfish Hypersensitivity, Epistaxis
About this trial
This is an interventional other trial for Shellfish Hypersensitivity focused on measuring nasal bleedings, Post-surgical healing, chitosan-based films
Eligibility Criteria
Inclusion Criteria:
- Adults aged 18-60
- Positive history of shellfish allergy
- Confirmation of allergy via previous reaction during oral challenge or convincing clinical history and testing.
Exclusion Criteria:
- Severe lung diseases: severe asthma, obstructive lung disease
- Severe cardiovascular disease: history of congestive heart failure, myocardial infarction, valvulopathy, or unstable tachy-or-bradyarrhythmia.
- Severe cerebrovascular disease: history of stroke or severe carotid stenosis.
- Presence of beta-blocker mediations.
- Patients unable to discontinue antihistamine medications or prednisone.
- Patients with severe or refractory anaphylaxis during prior oral challenge to shellfish, or those with documented systemic mastocytosis.
- Pregnancy
Sites / Locations
- St. Joseph's Health Care
Arms of the Study
Arm 1
Experimental
Study arm
Stage 1 After shellfish allergy is confirmed through the skin prick test and IgE analysis, Novapak packing will be applied to the patient's skin for 30 minutes on the anterior aspect of the patients' non-dominant arm. In case of pre-existing wounds, it will be applied to the other forearm. Participants will then be monitored for 1 hour, and any- reaction will be documented. In case of any symptoms of an allergic reaction, their study participation will be terminated. Stage 2 If no allergic symptoms are observed in stage 1, the patient's nose will be anesthetized with topical lidocaine. A piece of Novapak material will be applied to the participant's nasal cavity at the level of the inferior turbinate for 15 minutes. After removal, the participant will be monitored in the clinic for an hour. Any allergic reaction will be documented, including increased nasal congestion, rhinorrhea, or pruritis.