The Effect of Local Anesthetic Solution in the Bladder Prior to Botox Injections in the Bladder
Urge Incontinence, Overactive Bladder, Anesthesia, Local
About this trial
This is an interventional supportive care trial for Urge Incontinence focused on measuring Urge incontinence, Anesthesia, Local, Botulinum Toxins, Type A, Overactive Bladder, Alkalinized Lidocaine, Double-blind Method, Visual Analog Scale, Administration, Intravesical
Eligibility Criteria
Inclusion criteria:
- Female, age ≥18 years
- Admitted to treatment with BTX-A injections at the Urogynecological Clinic at Herlev Hospital due to UUI
- Able to read and understand Danish
- The female accepts to receive BTX-A injections as an outpatient treatment without the option of receiving sedative drugs
Exclusion criteria:
- BTX-A allergy
- Neurological disorder that may affect bladder function (e.g. Multiple sclerosis or spinal cord inju-ry)
- Neurological disorder with neuromuscular transmission failure (i.e. Mystenia Gravis)
- Ongoing UTI or symptoms of UTI prior to treatment, assessed by principal investigator
- Any other bladder pathology at the time of cystoscopy if identified (includes trauma, stones, tu-mor)
- Pregnancy/breastfeeding women
Sites / Locations
- Kvinde- og Bækkenbundssygdomme, klinik 1Recruiting
Arms of the Study
Arm 1
Arm 2
Active Comparator
Active Comparator
Alkalinized Lidocaine, then Placebo
Placebo, then Alkalinized Lidocaine
Participants will have Lidocaine Hydrochloride 20 mg/ml, 20 ml and Sodium hydrogen carbonate 1 mmol/ml, 10 ml (ie a total of 30 ml) installed in the bladder for 15 minutes prior to the BTXA-injection procedure. When signing up for the next BTXA-injection with a wash out period of minimum three months, participants will have the matching placebo containing Sodium Chloride 9 g/L, 20 ml and Sodium Chloride 9 g/L, 10 ml, a total of 30 ml installed in the bladder for 15 minutes prior to the BTXA-injection procedure.
Participants will have placebo containing Sodium Chloride 9 g/L, 20 ml and Sodium Chloride 9 g/L, 10 ml, a total of 30 ml installed in the bladder 15 minutes prior to the BTXA-injection procedure. When signing up for the next BTXA-injection with a wash out period of minimum three months, participants will have Lidocaine Hydrochloride 20 mg/ml, 20 ml and Sodium hydrogen carbonate 1 mmol/ml, 10 ml (ie a total of 30 ml) installed in the bladder for 15 minutes prior to the BTXA-injection procedure.