Study of a Comprehensive Intelligent Hypertension managEment SyStem (CHESS)

Inclusion Criteria for Sites: An electronic data collection system is routinely used at the clinic for hypertension management in PHC sites, and the distance between sites must be >2km; At least one drug of each of the five classes of recommended antihypertensive medications is available at the clinic: A: Angiotensin-converting enzyme inhibitors (ACEI; e.g., captopril or enalapril); A: Angiotensin receptor blockers (ARB; e.g., losartan or valsartan) B: β-blockers (e.g., atenolol, metoprolol, or bisoprolol) C: Calcium antagonists (e.g., nitrendipine, nifedipine, or amlodipine) D: Diuretics (e.g., hydrochlorothiazide, indapamide, or indapamide SR tablets) Has an outpatient clinic for hypertension treatment and staff are willing to take part in the study. Inclusion Criteria for Participants: Age ≥35 years and <80 years Local resident of the community/township who attends the PHC clinic for hypertension management, and will not travel for more than 3 months during the study period; Established diagnosis of essential hypertension, with uncontrolled BP before randomization (defined as office BP≥140/90mmHg, and 24-hour ambulatory BP≥130/80mmHg); Own and be able to use a smartphone daily; Be willing to participate in the study and sign the informed consent. Exclusion Criteria for participants: Physician-diagnosed or suspected secondary hypertension (e.g. hypertension caused by renal disease, renal artery stenosis, aortic stenosis, primary aldosteronism, pheochromocytoma/paraganglioma, Cushing's syndrome, thyroid dysfunction, intracranial disease, drug- induced, or rare monogenic genetic disease), or the presence of other structural heart diseases, such as aortic insufficiency, hypertrophic cardiomyopathy, or congenital heart disease; Office or ambulatory SBP≥180 mmHg and/or DBP≥110 mmHg before randomization; Physician-diagnosed atrial fibrillation; Physician-diagnosed CKD, estimated glomerular filtration rate (eGFR) <60 mL/min/1.73 m2 (if serum creatinine is available), or currently on dialysis treatment; Physician-diagnosed hepatic dysfunction, or ALT≥ 2*ULN; Currently at the unstable or terminal stage of any disease (e.g. new- onset cardiovascular and cerebrovascular diseases occurred within 3 months, malignant tumors); Intolerance to at least two classes of antihypertensive medications among A, B, C or D; Currently taking 3 or more antihypertensive drugs; The subject is pregnant or breastfeeding, or planning to become pregnant or breastfeeding during the study period; Have communication or cognitive disorders; Be unwilling to take antihypertensive drugs, or assumed poor adherence to treatment; The subject is participating in other clinical trials at the moment.