Whole Blood in Trauma Patients With Hemorrhagic Shock (WEBSTER)
Trauma, Trauma Injury, Trauma, Multiple
About this trial
This is an interventional treatment trial for Trauma focused on measuring whole blood, Blood Transfusion, Blood Component Transfusion, Hemorrhage, Advanced Trauma Life Support Care, Hemostatic resuscitation
Eligibility Criteria
Inclusion Criteria: Adult patients (> 18 years) Activating institutional trauma code for trauma patients with hemorrhagic shock. Candidate for massive transfusion (Patient with an Assessment Blood Consumption (ABC) Score ≥ 2 or at the discretion of the treating physician) Concurrent availability of whole blood or blood component therapy Exclusion Criteria: More than 4 hours from trauma to hospital admission More than 2 hours from hospital admission to randomization Transfusion of more than one packed red blood cell unit prior to randomization. Patients who have undergone surgery (laparotomy, thoracotomy, or sternotomy) before hospital admission. In-extremis patients with devastating injuries (expected to die within 60 minutes). Blood group other than to O or A and positive Rh factor Severe traumatic brain injury in which neurosurgical intervention is futile (partial decapitation, massive intracranial hemorrhage, or transcranial gunshot wounds). Burns over 20% of the total body surface area. Suspected airway burn. Cardiopulmonary resuscitation (CPR) before arrival at the ED. CPR for more than 5 minutes before randomization. Do not resuscitate order. Incarcerated/prisoners. Known pregnancy in the ED. Patient or legal representative who refuse to participate in clinical research studies.
Sites / Locations
- Fundacion Clinica Valle del LiliRecruiting
Arms of the Study
Arm 1
Arm 2
Experimental
Active Comparator
Whole Blood
Blood Components Therapy
Leukoreduced whole blood with a platelet-sparing filter. Participants will be transfused with 3 whole blood units. If the participant requires, an additional transfusion pack composite by 3 whole blood units will be administered.
1:1:1 ratio of red blood cells unit, plasma unit, and platelets unit. Participants will be transfused with 3 red blood cell units, 3 fresh frozen plasma units, and 3 platelets units. A second intervention with the same ratio can be transfused to participants if they require it.