FoodRx for Obesity Treatment

Inclusion Criteria: Provision of signed and dated informed consent form Stated willingness to comply with all study procedures and availability for the duration of the study Age >18 years BMI >30 kg/m2 at screening visit Screening positive for food insecurity using a score of >3 on the 10-item US Adult Food Security Survey Module109 Completion of baseline assessments Ability to engage in physical activity (i.e., can walk at least 2 blocks) Willing and able to provide pictures of food receipts to study team (or mail actual receipts) Ability to reliably receive packages at a consistent location in a timely manner Telephone or internet service to communicate with study staff For females of reproductive potential: agreement to use of highly effective contraception for during study participation Exclusion Criteria: Serious medical conditions (e.g., type 1 or type 2 diabetes, renal failure) that may pose a risk to the participant during intervention, cause a change in weight, or limit ability to adhere to the program's behavioral recommendations Significant psychiatric conditions (e.g., active substance abuse, schizophrenia) that may pose a risk to the participant during intervention, cause a change in weight, or limit ability to adhere to the program's behavioral recommendations Breastfeeding, pregnant or planning pregnancy in the next 6 months Planned move from the Philadelphia area in the next 6 months Weight loss of >5 kg in the previous 90 days Recently began a course of or changed the dosage of medication that can cause significant weight change (±5 kg) Previous or planned obesity treatment with surgery (excluding lap band if removed for >1 year) or a weight-loss device Use of prescription or over the counter medications for chronic weight management in the past 3 months Household member already participating in study due to potential contamination effects Lack of stable residence and ability to store and prepare food