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Examining Changes in Muscle Size and Body Composition Between Two Hypertrophy Resistance Training Programs in Males

Primary Purpose

Hypertrophy, Body Weight Changes, Muscle Size

Status
Completed
Phase
Not Applicable
Locations
Canada
Study Type
Interventional
Intervention
Resistance Training Program
Sponsored by
Dalhousie University
About
Eligibility
Locations
Arms
Outcomes
Full info

About this trial

This is an interventional basic science trial for Hypertrophy focused on measuring Exercise, Resistance Training

Eligibility Criteria

18 Years - undefined (Adult, Older Adult)MaleAccepts Healthy Volunteers

Inclusion Criteria: biological male age 18 years or older enrolled at Dalhousie university minimum 3-months of consistent (at least 2x/week) resistance training experience Exclusion Criteria: body fat percentage 25% or greater (obese) use of performance enhancing drugs that aim to increase rate of muscle growth (i.e., androgenic steroids, anabolic steroids, selective androgen receptive modulators, growth hormone).

Sites / Locations

  • Dalplex Fitness Centre

Arms of the Study

Arm 1

Arm 2

Arm Type

Active Comparator

Active Comparator

Arm Label

Train to failure

Train to non-failure

Arm Description

Training regime will be highly uncomfortable since it will be both physically and psychologically challenging to push to momentary muscular fatigue (MMF; i.e., failure).

Training regime will be moderately uncomfortable as participants will be training at a close proximity to failure (4-0 repetitions in reserve; i.e., non-failure).

Outcomes

Primary Outcome Measures

Segment girth (cm)
Upper arm (biceps) circumference, mid-thigh (quadriceps) circumference, waist (abdomen) circumference

Secondary Outcome Measures

Body composition (kg)
Fat mass, Fat-free mass, Total Body Mass (fat mass + fat free mass)
Body Fat Percentage
Fat Mass (kg) / Total Body mass (kg) * 100

Full Information

First Posted
December 19, 2022
Last Updated
August 11, 2023
Sponsor
Dalhousie University
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1. Study Identification

Unique Protocol Identification Number
NCT05667233
Brief Title
Examining Changes in Muscle Size and Body Composition Between Two Hypertrophy Resistance Training Programs in Males
Official Title
A Pilot Study Examining Differences in Waist, Upper-arm, Mid-thigh Circumference and Body Composition When Training to Momentary Muscular Fatigue Versus Close Failure-proximity Amongst Healthy Male Biological Sex University-aged Students
Study Type
Interventional

2. Study Status

Record Verification Date
August 2023
Overall Recruitment Status
Completed
Study Start Date
February 6, 2023 (Actual)
Primary Completion Date
March 27, 2023 (Actual)
Study Completion Date
April 3, 2023 (Actual)

3. Sponsor/Collaborators

Responsible Party, by Official Title
Principal Investigator
Name of the Sponsor
Dalhousie University

4. Oversight

Studies a U.S. FDA-regulated Drug Product
No
Studies a U.S. FDA-regulated Device Product
No
Data Monitoring Committee
No

5. Study Description

Brief Summary
This study aims to investigate if a less physically and psychologically taxing approach to resistance training can generate equal or greater outcomes when compared to a more physically and psychologically taxing approach.
Detailed Description
Resistance training is commonly used to improve body composition, gain strength, increase muscle size (i.e., hypertrophy) and prevent muscle atrophy (i.e., muscle wasting). The most optimal mode of building muscle remains unclear, however there are many mechanisms that can be tested to yield optimal results. One variable that can be manipulated when designing a hypertrophy-focused resistance training regimen is intensity (i.e., proximity-to-failure). Proximity-to-failure is defined as the number of repetitions remaining in a set of prescribed exercises prior to reaching momentary muscular failure (MMF). MMF is when an individual cannot complete the lowering or concentric phase of a given repetition with a full range-of-motion without deviation from the prescribed form of the exercise. For all lifters, particularly amongst older populations, it can be psychologically demanding to push to MMF, and may increase the risk of delayed onset muscle soreness (DOMS) and/or injury due to technical breakdown. In contrast, there is some evidence that suggests training to a slightly less intensity (i.e., within 1-4 repetitions in reserve [RIR]) may result in comparable hypertrophic results with less of a physical and psychological demand on participants. For these reasons, this study looks to investigate if an easier (i.e., less intense) approach to training such as training with repetitions in reserve (RIR), warrants similar or better muscle hypertrophy adaptations to MMF.

6. Conditions and Keywords

Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
Hypertrophy, Body Weight Changes, Muscle Size
Keywords
Exercise, Resistance Training

7. Study Design

Primary Purpose
Basic Science
Study Phase
Not Applicable
Interventional Study Model
Parallel Assignment
Model Description
Participants will be randomly assigned to one of two parallel groups (train to failure OR train to non-failure) and stratified according to their recent training experience (beginner [3-9 months experience], intermediate [9-18 months experience], advanced [>18 months experience]).
Masking
None (Open Label)
Allocation
Randomized
Enrollment
13 (Actual)

8. Arms, Groups, and Interventions

Arm Title
Train to failure
Arm Type
Active Comparator
Arm Description
Training regime will be highly uncomfortable since it will be both physically and psychologically challenging to push to momentary muscular fatigue (MMF; i.e., failure).
Arm Title
Train to non-failure
Arm Type
Active Comparator
Arm Description
Training regime will be moderately uncomfortable as participants will be training at a close proximity to failure (4-0 repetitions in reserve; i.e., non-failure).
Intervention Type
Other
Intervention Name(s)
Resistance Training Program
Intervention Description
Participants will undergo a high exertion machine-based resistance training protocol.
Primary Outcome Measure Information:
Title
Segment girth (cm)
Description
Upper arm (biceps) circumference, mid-thigh (quadriceps) circumference, waist (abdomen) circumference
Time Frame
8-weeks
Secondary Outcome Measure Information:
Title
Body composition (kg)
Description
Fat mass, Fat-free mass, Total Body Mass (fat mass + fat free mass)
Time Frame
8-weeks
Title
Body Fat Percentage
Description
Fat Mass (kg) / Total Body mass (kg) * 100
Time Frame
8-weeks

10. Eligibility

Sex
Male
Minimum Age & Unit of Time
18 Years
Accepts Healthy Volunteers
Accepts Healthy Volunteers
Eligibility Criteria
Inclusion Criteria: biological male age 18 years or older enrolled at Dalhousie university minimum 3-months of consistent (at least 2x/week) resistance training experience Exclusion Criteria: body fat percentage 25% or greater (obese) use of performance enhancing drugs that aim to increase rate of muscle growth (i.e., androgenic steroids, anabolic steroids, selective androgen receptive modulators, growth hormone).
Facility Information:
Facility Name
Dalplex Fitness Centre
City
Halifax
State/Province
Nova Scotia
ZIP/Postal Code
B3H 4R2
Country
Canada

12. IPD Sharing Statement

Plan to Share IPD
No

Learn more about this trial

Examining Changes in Muscle Size and Body Composition Between Two Hypertrophy Resistance Training Programs in Males

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