A Multicenter Open-label Clinical Study on the Prevention of Premature Ovarian Failure After HSCT
Hematopoietic Stem Cell Transplantation, Premature Ovarian Failure
About this trial
This is an interventional prevention trial for Hematopoietic Stem Cell Transplantation
Eligibility Criteria
Inclusion Criteria: Diagnosed with acute leukemia, MDS, lymphoma, multiple myeloma, SAA and other hematological diseases, with the indications for autologous or allogeneic hematopoietic stem cell transplantation. Female, aged 18-45 years. Ovarian function was normal before treatment. Volunteer to participate in clinical research and sign the informed consent form. Exclusion Criteria: No menstruation before treatment, undergone hysterectomy or ovarian surgery. Abnormal sexual development. Received radiotherapy. Combined with tumors affecting gonadal function. Deep vein thrombosis. Hypertension, liver and/or kidney dysfunction cannot tolerate hematopoietic stem cell transplantation.
Sites / Locations
- First Affiliated Hospital of Xian Jiaotong University
Arms of the Study
Arm 1
Arm 2
Experimental
Placebo Comparator
Leprorelin group
Control group
Leprorelin was given subcutaneously before each cycle of chemotherapy.
Normal salinewas given subcutaneously before each cycle of chemotherapy.