PROtecting Maternal Brains From Injury and Stroke (PROMIS)
Preeclampsia, Maternal Hypertension
About this trial
This is an interventional treatment trial for Preeclampsia focused on measuring Pregnancy, Near-Infrared Spectroscopy (NIRS), Preeclampsia, Maternal health
Eligibility Criteria
Inclusion Criteria: Aged 18 or older, within 6 weeks postpartum after a pregnancy lasting at least 20 weeks. Admitted to the inpatient obstetrics unit for treatment of preeclampsia with one or both of the following severe features: measured systolic BP ≥160 mmHg and/or diastolic BP ≥110 mmHg on two or more occasions, 15 minutes apart OR severe headache refractory to standard over-the-counter medications (acetaminophen, ibuprofen) Exclusion Criteria: Acute ischemic stroke Acute intracerebral or subarachnoid hemorrhage · Eclamptic seizures Any other neurological complication requiring transfer to the neurological intensive care unit or stroke step-down unit Prior history of stroke, seizures, traumatic brain injury, brain surgery, encephalitis, or demyelinating brain disease History of Reynaud's syndrome (contraindication to finger plethysmography) Inability to understand and consent to the study
Sites / Locations
- Columbia University Irving Medical Center / NewYork-Presbyterian Hospital (NYP)Recruiting
Arms of the Study
Arm 1
Arm 2
No Intervention
Experimental
Observational Cohort
Interventional
Participants treated with standard guideline-based care for 24 hours. Blood pressure treatment thresholds will be used according to standard practice parameters
Autoregulation-guided blood pressure management for 24 hours. Blood pressure will be measured every four hours by arm cuff; however, in lieu of predetermined blood pressure treatment thresholds, an optimal mean arterial pressure (MAP) range will be chosen based on limits of autoregulation calculated in real-time for the previous four hours for each participant. Choice of medications and dosing will be left to the primary clinical obstetrics team.