Macrophage Programing in Acute Lung Injury: MiniBAL
Acute Respiratory Distress Syndrome, Ventilator Associated Pneumonia
About this trial
This is an interventional basic science trial for Acute Respiratory Distress Syndrome
Eligibility Criteria
Inclusion Criteria: Written informed consent (by surrogate if unconscious or if altered mental status), verbal consent may be used as necessary. Admission to the intensive care unit. Orally/nasally intubated Expected to remain mechanically ventilated for at least 48 hours after the first study procedure. Exclusion Criteria: Treatment with immunosuppressants in the prior 3 months (antineoplastic agents, tumor necrosis factor alpha antagonists, cyclosporine, methotrexate, azathioprine or mycophenolate. Treatment with glucocorticoids for septic shock is acceptable. History of solid organ or bone marrow transplantation History of chronic lung disease (e.g. COPD, pulmonary fibrosis, cystic fibrosis). Severe or massive hemoptysis At significant risk for bleeding (INR > 3 or PTT > 3x normal) Presence of an advanced directive to withhold life-sustaining treatment Morbid state or expected to survive less than 14 days because of an advanced co-morbid medical condition. Pregnancy
Sites / Locations
- Intermountain Health - St. Joseph's Hospital - National Jewish HealthRecruiting
Arms of the Study
Arm 1
Other
Study Population Group
People in the ICU on mechanical ventilation due to a diagnosis of ARDS or any other diagnosis that requires mechanical ventilation (following surgery, sepsis without lung involvement, seizures)